Search PubMed⌕ Search

Biomedical subjects

C Servadio

Publications and source records attributed to C Servadio.

At least 181 records · Page 10Linked to original sources
PubMed1980

Early combined hormonal and chemotherapy for metastatic carcinoma of prostate.

Twenty-five patients with confirmed Stage D carcinoma of the prostate were treated by a combination of bilateral orchiectomy, estrogen, and chemotherapy soon after diagnosis was established. Patients were given diethylstilbestrol (DES) 3 mg. daily, and a weekly intravenous injection of 5-fluorouracil (5-FU) 10 mg./Kg. and cyclophosphamide 10 mg./Kg. They were followed up for between sixteen and forty-two months. The majority of patients reported a subjective improvement. Objectively, the primary tumor shrunk by more than 50 per cent in 84 per cent of the patients, while in 64 per cent there was improvement in the lesions shown on bone scan. The cumulative survival rate during three and one-half years was 76.5 per cent. These encouraging preliminary results appear to justify the early initiation of combined therapy in larger numbers of patients with Stage D prostatic carcinoma.

Aged↗
PubMed1980

Seminoma in childhood.

We report on an 8-year-old boy who had a seminoma 2 years after orchipexy of the left testis. Seminoma is a rare tumor in childhood and, to our knowledge, this is the youngest patient with seminoma to be reported in the literature.

Child↗
PubMed1980

Some properties of acid and alkaline phosphatase in seminal fluid and isolated sperm.

Activities of acid and alkaline phosphatases were examined in spermatozoa isolated from 177 semen samples differing in sperm counts. Alkaline phosphatase was also determined in seminal fluid. The enzymes were assayed using disodium p-nitrophenyl phosphate as substrate and were studied with respect to susceptibility to various concentrations of tartrate (acid) and to heat (alkaline). Electrophoretic separation of alkaline phosphatase from seminal fluid was performed using an Helena apparatus. The results showed that acid phosphatase activity in spermatozoa decreased with increase in sperm densities and that elevation of tartrate from 0.028 to 0.17 M usually correlated an inhibition of the enzyme from 72% to 78% (mean values). Alkaline phosphatase was very low in sperm and generally below the sensitivity of the method used. Activity of alkaline phosphatase in seminal fluid showed a tendency to increase with the increase in sperm counts, but the significance of differences between groups was not statistically valid. Exposure of seminal fluid to 55 degrees C for 16 min resulted in enzyme inactivation of about 90% and in this respect the alkaline phosphatase resembles the enzyme of bone origin. The electrophoretic pattern, however, did not confirm this view and the type of alkaline phosphatase in seminal fluid is not clear.

Acid Phosphatase↗
PubMed1980

Properties of spermatozoa from normospermic and oligospermic human semen fractionated on columns of discontinuous gradients of albumin.

One hundred and twenty-eight samples of human semen, divided into four groups according to sperm counts, were fractionated on two types of columns of discontinuous gradients of bovine serum albumin (3%, 15%, or 7.5%, 17.5%). In addition to morphology and motility, protein and DNA contents of spermatozoa as well as microscopical pictures of their sediments were examined in order to assess sperm sensitivity to damage in the course of common isolation procedures. The proportions of morphological normalcy and motility grades within the groups were higher in the bottom column fractions than in the middle ones; both showing prevalence over parent semen. Motility percentages were also higher in the bottom than in middle fractions, but no prevalence over parent semen was observed. Protein and DNA contents of spermatozoa were similar in the two fractions within the same group. Comparison between groups revealed an increase in percentages of normal morphology and motility and a decrease in protein and DNA with elevation of sperm density. Microscopic examinations revealed similar degrees of contamination in both fractions which were more abundant in oligospermia than in normospermia. It is suggested that sperms with better morphology and motility are as sensitive to common laboratory procedures as cells of lower quality originating from the same specimen.

Cell Fractionation↗
PubMed1980

Detection of cancer in patients by reduced lymphocytic cortisol metabolism-enhancing effect.

A double-blind study was done on the plasma from 59 hospitalized patients to determine whether a diminished lymphocytic cortisol metabolism-enhancing effect among cancer patients could be used to distinguish them from persons with noncancerous diseases. Known concentrations of human lymphocytes from healthy donors were incubated with cortisol in media containing 50% phosphate-buffered saline (PBS) and 50% of one of the following additives: 1) homologous plasma (HP), 2) plasma from the patient being tested, or 3) additional PBS. Plasma in which the metabolism-enhancing effect was less than 70% of that obtained with HP was considered to be that of a cancer patient. Among the 19 patients known to have cancer, there were only two false-negative results, whereas among the 40 patients diagnosed as having noncancerous diseases, there were six false-positive results. Thus the test findings and the pathologic diagnosis were obviously correlated in approximately 90% of the patients.

Adolescent↗
PubMed1979

Widespread dissemination of gelfoam particles complicating occlusion of renal circulation.

Embolization of renal circulation by Gelfoam particles in a thirty-two-year-old man with renal carcinoma was followed by retrograde regurgitation of the injected particles upstream, with resultant occlusion of the celiac trunk and the superior mesenteric artery. This was followed by a stormy clinical course, which the patient survived. Several possible explanations are offered for the occurrence of this complication.

Adult↗
PubMed1979

Spontaneous extravasation of urine in chronic ureteric obstruction.

Two cases of spontaneous extravasation of urine in chronic ureteric obstruction are presented. In 1 case the long-standing partial ureteric obstruction was caused by enlarged lymphomatous glands, and extravasation was followed by a perinephric abscess. In the second case, believed to be unique, there was a moderate chronic ureteric obstruction post irradiation, and extravasation was induced by a sudden rise in intra-abdominal pressure due to vomiting.

Adult↗
PubMed1979

Spontaneous rupture of renal and ureteral tumors presenting as acute abdominal condition.

We report on 3 patients who presented with an acute onset of abdominal pain, a palpable abdominal mass and a rapid decrease in hemoglobin. In 2 patients a spontaneously ruptured hypernephroma was found and the other patient had a squamous cell carcinoma of the ureter with bleeding into the tumor. Although in all 3 cases the tumors were at an advanced stage of development, the patients had been entirely free of urological symptoms until shortly before hospitalization. The importance of considering the possibility of spontaneous rupture of such a tumor in the evaluation of cases of an acute abdomen is stressed.

Abdomen, Acute↗
PubMed1979

Benign cholestatic jaundice after nephrectomy for pyonephrosis and sepsis.

Severe benign postoperative intrahepatic cholestatic jaundice appeared immediately after nephrectomy in a patient with nephrolithiasis and septicemia. Convalescence was uneventful and no treatment was necessary. This diagnostic possibility should be considered whenever jaundice appears postoperatively for pyonephrosis and septicemia.

Cholestasis↗
PubMed1979

Oestrogen-induced renal carcinoma.

Oestrogen may be implicated as an aetiological factor in the development of some renal carcinomas in man. The development of a renal carcinoma in 2 patients who had been treated with low-dose oestrogen for periods of 3 and 3 1/2 years because of prostatic carcinoma is described. It is suggested that patients receiving prolonged oestrogen therapy should be evaluated for the presence of a renal carcinoma at regular intervals.

Aged↗
PubMed1979

Occult progressive renal damage in the elderly male due to benign prostatic hypertrophy.

A review of the case histories of 345 patients who underwent protatectomy showed that 1.7 percent (6 patients) had "occult and progessive renal damage" secondary to prostatic hypertrophy. All these men were over the age of 60 and the disturbances in micturition were so mild that the patients were unaware of, or chose to ignore them. The presenting symptoms were nonspecific and included generalized weakness, anorexia, nausea, constipation, and weight loss. Investigation revealed impaired renal function of varying degrees. Prostatectomy was associated with a dramatic improvement in all 6 patients. Physicians should be aware of the clinical entity of occult and progressive renal damage secondary to obstruction of the bladder outlet, especially in the elderly male. Uremia can develop with minimal urinary symptoms. Elderly men often suppress or deny their symptoms because of the fear of operation.

Age Factors↗
PubMed1979

Acid phosphatase activity in human semen.

Acid phosphatase activity was examined in normal and abnormal human semen of individuals not suffering from testosterone deficiency. No differences in enzymatic activity between the examined groups were observed. The presence of tartaric acid caused an inhibition of about 95% of enzymatic activity.

Acid Phosphatase↗
PubMed1979

High sperm densities and the quality of semen.

Thirty semens with sperm densities above 200 million per milliliter from patients with fertility disorders were examined for volume, motility, vitality, and morphology of spermatozoa, and for fructose content as well as for percentile decreases with time of activity and viability. In addition, blood levels of follicle stimulating hormone, luteinizing hormone, testosterone, and prolactin were estimated. Percentages of motility, vitality, and morphological normality, motility grades, and percentile decreases in both activity and viability were found to be comparable with those of oligospermic specimens. On the average, volume of semens were lower by about 30% than in normo- and oligospermia. 42% of the investigated semens had low fructose values (below 1 mg/ml). In about 60% of patients the prolactin levels were low (2-5 ng/ml). Follicle stimulating hormone, luteinizing hormone, and testosterone were either within normal range or slightly decreased. Despite the above abnormalities, the overall numbers of "normal" spermatozoa per ejaculate were not inferior to those usually present in normospermic specimens, suggesting that factors of presently unknown nature, involved in regulation of both proliferation and spermatogenesis, might be responsible for fertility disorders in these conditions.

Follicle Stimulating Hormone↗