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Biomedical subjects

C Servadio

Publications and source records attributed to C Servadio.

At least 199 records · Page 11Linked to original sources
PubMed1978

Unilateral adrenalectomy and pituitary irradiation in the treatment of ACTH-dependent Cushing's disease in children and adolescents.

In four juvenile patients with Cushing's disease, the therapeutic approach used was unilateral adrenalectomy followed by irradiation of the pituitary. The follow-up time of these patients has ranged from 1.5 to 10 years. All four are clinically well. Concentrations of adrenal steroids are within normal limits and they require no additional medication. It is felt that this method gives young patients the chance for normal growth and pubertal development as well as a normal social life, so important in the stressful adolescent years, thus avoiding the handicap incurred by bilateral adrenalectomy and the consequent requirement for continuous substitution therapy.

Adolescent↗
PubMed1977

Specific attachment of T-lymphocytes from cancer patients to tumor cells.

The present study describes a new approach for detecting the immune reaction of peripheral blood lymphocytes of cancer patients against tumor antigens. T-lymphocytes from patients with carcinoma of the urinary bladder were found to attach specifically to monolayers of cells of urinary bladder carcinoma line (T24). The attached T-cells were identified by their capacity to form E-rosettes with sheep red blood cells. The number of rosette forming--target attached lymphocytes (RF--TAL) was 6 times higher in bladder carcinoma patients than in healthy controls or in patients bearing other types of cancer.

Antigens, Neoplasm↗
PubMed1976

Ascites in patients undergoing maintenance hemodialysis. Report of six cases and physiopathologic approach.

Six patients with chronic uremia in whom ascites developed during maintenance hemodialysis are described. Their clinical and biochemical findings are reviewed and compared with data of 10 hemodialyzed patients without ascites. Liver cirrhosis was the origin of ascites in only one case. Hypoalbuminemia, liver cirrhosis, congestive heart failure, peritonitis, peritoneal tuberculosis and carcinomatosis were uniformly absent in the other patients. Long-term and marked overhydration seems to be at the origin of ascites. Lack of peripheral edema, probably due to ascites compartmentalization, was a constant finding in every noncirrhotic patient with ascites. When long-term overhydration was stopped after successful kidney transplantation or by means of diminished water and salt ingestion, reversal of the syndrome was attained. Nevertheless, ascites because of liver cirrhosis was not influenced by means of kidney transplantation. In three patients with ascites who did not receive a transplant, a significant reduction in water and salt ingestion was reached after intensive psychotherapy which led to reversal of the ascitic syndrome. In one anephric patient ascites did not develop despite water overloading. Survival has not been influenced by the formation of ascites. Further research is needed to determine the mechanism of sodium transfer across the peritoneal membrane. Influence of humoral factors can be considered, if an active transport mechanism could be demonstrated.

Adolescent↗
PubMed1975

Subcutaneous intraperitoneal prosthesis for maintenance peritoneal dialysis.

A subcutaneous intraperitoneal proslysis has been successfully implanted in three chronic uraemic patients. Fifty peritoneal dialyses have been done during 6-3 patient-months, without complications. During this short experience, peritonitis was not seen at all. The patients' acceptance of the prosthesis was good. Lack of abdominal tubes or bags is a remarkable technical improvement of this device.

Adult↗
PubMed1975

Nortriptyline hydrochloride in urology.

Forty female patients suffering for long periods from frequency, urgency, and dysuria without any definite organic cause received nortriptyline chloride for three weeks. In 75 percent there was either considerable improvement or total disappearance of urinary complaints. At the same time the in vitro effects of the drug were tested using the isometric muscle contraction technique. Nortriptyline was found to have anticholinergic properties. The importance of this effect in the clinical study and the possible mode of action of the drug are discussed.

Acetylcholine↗
PubMed1975

Conservative vs. surgical treatment of vesicoureteral reflux.

The treatment of choice in vesicoureteral reflux in children is discussed on the basis of experience with 160 refluxing ureters. Two-thirds of the ureters responded well to conservative nonsurgical treatment and the majority of these are now completely cured. Thirty-three ureters, not responding to conservative measures, were treated surgically by the Leadbetter-Politano or Bischoff methods. It is concluded that 1) conservative treatment should be attempted before recourse to surgery and 2) Bischoff's technique should be given first consideration in cases with dilated and poorly functioning ureters.

Adolescent↗
PubMed1975

Delayed excretion of conjugated sulphamethoxazole in uraemia.

Persistence in the serum of free and conjugated sulphamethoxazole was estimated in five normal controls and in nine uraemic patients with creatinine clearances under 20 ml/min, after a single one-gram dose of the drug. In the uraemic group delayed disappearance of the free drug was found. Conjugated sulphamethoxazole retention was 62.44% at 24 hr after the oral load, and 13.7% 19 days later. Risk of accumulation of sulphamethoxazole in uraemia is emphasised. Re-evaluation of the use of this drug in patients with impaired renal function is recommended.

Humans↗