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Biomedical subjects

C Salmon

Publications and source records attributed to C Salmon.

At least 145 records · Page 8Linked to original sources
PubMed1981

Antigen Nou. A new high frequency Rh antigen.

Serum from a D--/D-- allo-immunized woman is found to contain 3 separable antibodies: anti-e, anti-Ee (Rh 17) and a third component which, in contrast to 5 other sera from people with Rh deleted phenotypes, reacts strongly with red blood cells from Mrs Nou., a DIV(C)--/DIV(C)--black woman. The latter component studied by elution and coagglutination using Nou. cells reacts with a hitherto unrecognized public antigen within the Rh system. 2750 random donors, 2Rh mod. individuals and 17 people with public minus phenotypes in other blood group systems were found to express the antigen. 2 Dc--/Dc--, 4 D--/D-- and 4 Rh nul samples were non reactive. The identity of the antibody with anti-Hr (Rh 18) was ruled out since the original anti-Hr failed to react with Nou. red blood cells.

Agglutination↗
PubMed1981

A complete automatic procedure for the characterisation of irregular antibodies.

Computer equipment has been attached to a normal double channel AA. Is consists of a micro-computer, a printer, a mini-floppy disk system and an analog to digital conversion interface which is the link between the AA and the computer. This "assembly line" was designed with three aims in mind: 1) to complete the automation of the chain by means of computerized management of the sampling (and ultimately its identification); 2) to perform an automatic antibody screening and identification from the sampling to the editing of all possible solutions; 3) to insert this test into a larger computerized context which consists of an automatic management and selection of the test red blood cell panel.

Agglutinins↗
PubMed1981

A family demonstrating the independence between Lutheran and Auberger loci.

The family presented here demonstrates the absence of a close relationship between the Auberger loci on one hand and the Lutheran and secretor loci on the other. This absence of a close relationship between the Lutheran and Auberger loci is important in understanding the inhibition mechanism of the Au antigen when in the presence of the dominant In(Iu) allele.

Alleles↗
PubMed1981

Distribution of blood group antigens in adult pancreas.

Numerous blood group antigens are present in different human tissues where they appear as immunological markers of certain structures. The Pr antigen is the only antigen present in the islet of Langerhans. The A, B, H and Lewis antigens are present in the centro acinar cells and the Pr and Lewis antigens are found on the membrane of the pancreatic ducts. A, B, H and Pk antigens are expressed in the capillaries. These kinds of studies could be important for the transplantation of the endocrine pancreas.

Blood Group Antigens↗
PubMed1981

Anti-nomifensine antibody causing immune hemolytic anemia and renal failure.

An anti-Nomifensine antibody was identified in a patient with immune hemolysis and renal failure who was under Nomifensine therapy. The anti-drug specificity of the antibody was confirmed by inhibition assays using Sepharose gel-Nomifensine conjugates. Preliminary screening tests for anti-Nomifensine antibody in a population of 104 patients treated by the drug showed no further example of such immunization.

Agglutination Tests↗
PubMed1981

[Immunological safety in blood transfusion. Current practical rules (author's transl)].

Immunological safety in blood transfusion necessitates good organization, on one hand in the department responsible for the reception of the patient, and on the other hand, in the immunohematological laboratory. Perfect cooperation between the clinicians and the biologists is indispensable. Four tests are essential to ensure the biological surveillance of blood transfusions: ABO and Rhesus (D) typing, screening of irregular agglutinins, the compatibility test and the final check at the patient's bed side. Justified indications for each examination and their perfect technical realization are the two conditions necessary for the success of blood transfusions, it is still very frequent to see these precise rules neglected.

Autoantibodies↗
PubMed1981

Thermodynamic and immunological properties of a monoclonal antibody to human blood group A.

A murine anti-A monoclonal antibody was obtained by the hybridoma technique. This antibody, of an IgM nature, is capable of agglutinating A1, A2 and A3 red blood cells. Thermodynamic study confirmed its monoclonal character; its association constant is 1,6 10(6) l/mole. The enthalpy change of the antigen/antibody reaction is nul which indicates the absence of the role of temperature on antibody fixation. This weak affinity makes it necessary to concentrate the supernatant so as to enable use of these reagents under the same conditions as those used at present.

ABO Blood-Group System↗
PubMed1980

[Red cell autoimmunization in a "normal" population. 63 cases (author's transl)].

Anti-red auto-antibodies were found in 69 out of 892 000 blood donors aged between 20 and 60 years, 63 of whom were followed for up to five years. This would suggest an overall incidence of 1 in 13 000 members of a "normal" population. Uncontrolled methyl-dopa treatment could be incriminated in 25% of cases. Only 10% of autoimmune subjects had slight confirmed anaemia, but 72% had biological evidence of red cell destruction (i.e. hyper-reticulocytosis, elevated serum bilirubin levels and shortened red cell life span), which demonstrates the presence of subclinical autoimmune haemolytic disease in apparently normal people. The anti-red cell auto-antibodies were of the IgG type in 97% of the subjects and were associated with various anti-tissue antibodies in 41%, thus pointing to a multisystem autoimmune disorder. In most cases the abnormality persisted or spontaneously regressed during the observation period, but long-term follow-up is required to determine whether asymptomatic red cell autoimmunization is harmless or potentially dangerous.

Adult↗
PubMed1980

[Studies of immunological status, following autologous bone marrow transplantation in man (author's transl)].

Following transplant, circulating immunoglobulin levels fell moderately and remained depressed less than 2 months for IgG, and for variable and longer periods of time for IgM and IgA. Repeated quantitative determinations of antibodies against multiple antigens did not show any decrease in the pretransplant levels. Indeed some patients developed herpes and cytomegalovirus infections to which they responded by a sharp increase in antibody titers. In 2 cases, a primary immunization was demonstrated (against CMV and BK virus) with increasing levels of IgM and IgG antibodies. Lymphocyte counts in peripheral blood returned to 500 mm# between day 10 and 29 (median day 18) and to pretransplant values within 6 weeks. Non specific stimulation of lymphocytes by mitogens in the immediate post-transplant period showed a decreased response to PHA and Con A, whereas the responses to pokeweek mitogens and alloantigens were only slightly diminished. The degree of the responses was related to the dose of cryopreserved marrow infused. We conclude that:--although the minimum dose for autologous bone marrow transplantation in man is around 0,5 10(8) nucleated bone marrow cells/Kg, much higher doses should be used to ensure faster and better restoration of immune reactivity.--The similarity of the immunological dysfunction following autologous and allogeneous bone marrow transplantation suggest that, in the immediate post-transplant period, the role of GVHD in cellular immunity depression may be minimal.

Bone Marrow Transplantation↗
PubMed1980

Different H deficient phenotypes present in one kindred.

Two different H deficient phenotypes are observed in one kindred. Three of them in two generations of a same family appear as Bombay like. In the other branch of the kindred, an Hz phenotype (as described in the editorial of this issue) is observed. The most simple explanation is that the three Bombay like phenotypes correspond to Hz ABH non secretor (Hz sese) individuals, this being indistinguishable from a true Bombay. The high level of I antigen in the plasma of the three Bombay like (as observed in Hz in contrast to true Bombay) could favour such an hypothesis. According to ORIOL'S new hypothesis [5], III2, III3 and IV2 would genetically be hh sese, III8 would be hh Se and the h Se would therefore be a recombining haplotype (the original haplotype being h se).

ABO Blood-Group System↗
PubMed1980

ABH and Lewis glycosyltransferases in human red cells, lymphocytes and platelets.

The alpha-O-N-acetylgalactosaminyl-, alpha-3-D-galactosyl- and alpha-2-L-fucosyltransferases, the direct products of the respective A, B and H blood group genes have been identified in red cells, lymphocytes and platelets homogenates from secretor and non-secretor individuals of appropriate ABO group. The H enzyme was not detectable in red cell membranes from Bombay individuals. Since the uptake of A antigen from the plasma has been shown at least for red cells [10] and lymphocytes [25], the present results suggest that the ABH determinants of the blood cells may arise both from intrinsic and extrinsic origin, but the relative contribution of each mechanism is not known. In contrast, the Lewis enzyme was absent or inactive in all the investigated blood cell samples, which can be considered as an additional proof that the Lewis antigens of these cells are entirely derived from the plasma.

ABO Blood-Group System↗
PubMed1980

Allo antibodies in partially silent Rh phenotypes. Evidence for a possibly new high frequency Rh antigen.

Seven sera from 4 D -- --, 2 Dc -- and 1 DIV(C) -- immunized women were studied through extensive absorption-elution and coagglutination tests against a panel of common and depressed or deleted Rh phenotypes. A separable anti-e was regularly present in all sera together with an anti-Ee antibody which often showed stronger reactivity with e antigen. A possibly new anti-public Rh antibody was further separated in the serum from a D -- -- individual. The corresponding antigen is expressed on common, DIV(C) -- and depressed Rh phenotypes used, and is absent from Dc --, D -- -- and Rh null cells.

Female↗