Trace elements and vitamin requirements in infants on total parenteral nutrition (T.P.N.).
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Biomedical subjects
Publications and source records attributed to C Ricour.
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The contribution of radiological examinations to the evaluation of radiation lesions of the digestive tube in 17 children is discussed. The lesions observed were stenosis, submucous infiltration, and mesenteritis from vasculitis. Ali the patients had been treated with high irradiation doses varying from 3,000 to 5,500 rads. Clinical manifestations appeared after intervals of from 2 months to 13 years, but the anatomical lesions seemed to occur early and to show little change once they were established. Except when an acute occlusion was present, radiological examination consisted of a barium meal and follow through, able to demonstrate anomalies in the folds, stenosis, dilatation, or thickening and matting of the intestinal loops.
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Small bowel adaptation after extensive intestinal resection has been studied in 5 children. A segmental perfusion technique was used to evaluate the kinetics of glucose absorption and sucrose hydrolysis. The activity of 6 brush border hydrolases and the mean villus height were measured in intestinal biopsies. Glucose absorption was greater than in 3 control children of the same age and was almost complete. Sucrose hydrolysis was increased in the same proportion and the maximum capacity of the segment was 2 mmol/min/20 cm as compared to 1.2 mmol/min/20 cm in the control group. Absorption of the released monosaccharides was complete for glucose and as high as in controls for fructose. Brush border hydrolase activities were identical to those of controls whereas the mean villus height was increased (438 micrometer as compared to 342 micrometer) although the difference was not significant. These results demonstrate the functional adaptation of the remaining small bowel and confirm that it is due to compensatory hyperplasia.
Three cases of a primary disorder of intestinal motility which was responsible for neonatal functional intestinal obstruction are reported. This serious condition affected the small intestine and the colon and was difficult to treat. Early operation and prolonged intravenous alimentation was necessary. It is distinct from Hirschsprung's disease because of the presence of ganglion cells and because of the abnormalities of the myenteric plexus on silver staining. However the clinical symptoms and the decreased intraparietal cell V.I.P. concentration in pathological areas are similar in both conditions.
The authors present radiological aspects of small bowel after extensive resection. They describe the main phenomena related to compensatory hypertrophy: dilatation of the loops, mucosal fold-thickening and motor disturbances. The main complications demonstrated by the radiological examination are presented; gallstones, non-functioning anastomosis, bacterial overgrowth.
The aim of this study was to look for a difference in fasting serum gastrin levels or in serum gastrin response to oral feeding between infants with hypertrophic pyloric stenosis and normal controls. Fasting serum gastrin levels were measured by radioimmunoassay in 10 patients with pyloric stenosis, before pyloromyotomy and 7 and 15 days after it, and in 11 controls. In addition, the serum gastrin responses to a casein hydrolysate meal were studied in both groups (in the patients, 7 days after operation). The fasting serum gastrin levels in the patients did not differ from those in the controls before operation, but they did so after it. The serum gastrin response to feeding in patients after pyloromyotomy was no greater than in controls.
Serum vitamin A, vitamin E, vitamin B12, folate and leucocyte vitamin C were measured in 45 patients between the ages of one month and 2 1/2 years who were receiving total parenteral nutrition. After allowing for variations in intake the following recommendations are made: Vitamin A (central vein) 2,500 i.u./day (peripheral vein) 1,000 - 1,500 i.u./day. Vitamin E (peripheral vein) 0.8 mg/kg/day, Vitamin B12 (central vein) 0.8 - 1 microgram/day, Folate (central vein) 10 - 80 microgram/day, Vitamin C (central vein) 25 mg/day.
A 15 year old adolescent with Crohn's disease who received total parenteral nutrition for three months developed riboflavin deficiency. The aetiology, the clinical picture and the method of diagnosis of this unusual deficiency are reviewed. The importance of an adequate intake of vitamin B2 and the other B group vitamins, particularly in the malnourished, is emphasied.
Twelve children aged 1 to 8 months with severe intestinal disorders that had necessitated treatment from birth with continuous parenteral and/or enteral nutrition were recorded for 24 hours. The analysis of the EEG, their behaviour and their activity showed that the distribution of sleep and movement during the night was similar to that of normal babies fed on demand. The total duration of sleep and the longest sustained sleep were slightly reduced. The authors think that the suppression of feeding rhythms do not alter the pattern of waking and sleeping.
In the light of 350 cases of E.P.N., prevention of complications rests upon: 1. supply of hydroelectrolytics and proteinoenergetics at reduced dosage, initially, and then adapted to the anabolic stimulation, taking into consideration the correlations which exist between calories, nitrogen, calcium, phosphorus, zinc and vitamins, particularly those of the B-complex; 2. the necessity to achieve a progressive withdrawal through the supply of enteral elementary substances which will permit a modulated new induction of the digestive enzymatic secretory activities. The indications for such a highly technical program may emanate in the course of serious malabsorption with severe denutrition within the framework of inflammatory and vascular enteropathies and in the presence of certain metabolic disturbances, either congenital or acquired.
Fifty cases of gastroschisis were treated at the Hôpital des Enfants Malades from 1960 to 1976. Up to 1973, 90% of the babies died. From 1974-1976, 17 infants were treated and 10 (59%) were cured. The authors emphasise the importance of intravenous feeding, the prevention of infections and intensive respiratory care. Complete intestinal ileus for more than one month is associated with a bad prognosis. The use of drugs and further surgery in this situation in discussed.
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During the past 5 yr, 25 children ranging in age from 10 days to 14 yr have been treated for single or multiple severe enterocutaneous fistulas. There were two deaths. In 24 cases out of 25, initial treatment was nonsurgical and consisted of nutritional support (by total parenteral nutrition in 20, and constant rate enteral feeding in 4) and was associated with local treatment. Successful closure was achieved without surgery in 13 cases, and 11 secondary operations were performed, with success in 9. The addition of nutritional methods has completely changed the prognosis of enterocutaneous fistula.
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The bacterial flora of the small bowel was studied in infants with stasis after surgery. Samples were obtained, with radiological assistance, by duodenal aspiration and then immediately analysed by the laboratory in blind tests, both qualitatively and quantitatively. There were two groups of patients: one receiving parenteral nutrition and a second on enteral elementary diet; patients without any gastro-intestinal tract disease formed the control group. Pseudomonas aeruginosa and Enterobacteria were isolated significantly more often in both groups of patients compared to the control group. Quantitatively, the predominant flora -- and not total flora -- was different in the three groups. When considering bacteriological species, only P. aeruginosa (greater than 10(6)/ml) differed significantly in numbers in both groups compared to the control group. With these bacteriological investigations, the "contaminated proximal small bowel syndrome" is better defined and a group of high-risk patients may be identified.