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Biomedical subjects

C Rey

Publications and source records attributed to C Rey.

At least 343 records · Page 19Linked to original sources
PubMed1984

Methyltin intoxication in six men; toxicologic and clinical aspects.

Neurologic and psychiatric symptoms such as headache, tinnitus, defective hearing, changing desorientation and aggressiveness are initial symptoms of methyltin chloride intoxication. Some patients also developed epileptic equivalents, such as dreamy attacks and central ventilation transaminases. Laboratory findings included low levels of serum potassium, leucocytosis and elevated transaminases. The excretion rate of tin in the urine correlated with the severity of the intoxication. There was no measurable effect of plasma separation or d-penicillamine therapy on tin excretion in the urine or on the clinical picture. The long-term prognosis of severely intoxicated persons is poor. Neurohistopathologic findings confirm the animal studies by Brown et al and the severe damage and cell necrosis in the hippocampus area. To prevent such events workers need to be warned of the risk and dangers of working with organo-metallic compounds. The effectiveness of protective clothes and gas masks should be checked. In exposed workers regular testing is advised of tin concentrations in the urine.

Accidents, Occupational↗
PubMed1983

Influence of exercise on serum levels of myoglobin measured by radioimmunoassay.

To determine the influence of exercise on serum levels of myoglobin, serum levels of this protein were determined by RIA in 90 healthy men, divided as follows: (1) Basal control (no exercise) 25 cases; (2) Moderate exercise (after subject had been working for 12 h in Medicine Emergency Service) 19 cases, and (3) Intensive exercise: (a) football professional (45-min match) 10 cases; (b) football amateur (45-min match) 10 cases; (c) basketball professional (45-min match) 10 cases, and (d) basketball professional (90-min training) 16 cases. Our results led us to the following conclusions. (1) Moderate exercise, such as the usual daily work, does not modify myoglobin levels; (2) Myoglobin serum levels after exercise increase in nearly all individuals. They are higher in untrained people; (3) There seems to be a correlation between exercise intensity and increase of myoglobin serum levels, and (4) The detection of serum myoglobin by RIA may have a wide field of application for sport medicine.

Adolescent↗
PubMed1983

[Atrioventricular discordance without ventriculo-arterial discordance. Apropos of 3 cases].

Three cases of atrioventricular without ventriculo-arterial discordance are reported. The first case was a young woman with situs solitus, atrioventricular discordance and ventriculo-arterial concordance, large atrial and small ventricular septal defects. The functional tolerance was relatively good. The second case was an infant girl with dextrocardia by dextroversion and abdominal situs solitus. The child had atrioventricular discordance with ventriculo-arterial concordance and an ostium primum atrial septal defect. Cyanosis was mild and, in addition, complete heart block was diagnosed on the fourth day of life. The functional tolerance was good in this case too and growth was normal. The third case was a young girl with levocardia, atrial situs inversus, and abdominal situs inversus. A double outlet right ventricle was diagnosed at catheterisation with atrioventricular discordance, ventricular septal defect, and severe valvular and infundibular pulmonary stenosis. The first palliative procedure was performed at eight months: a left Blalock-Taussig anastomosis. As cyanosis has recurred a second procedure is being considered, the child now being 5 years old. Different forms of atrioventricular discordance without ventriculo-arterial discordance have been described: atrioventricular discordance with ventriculo-arterial concordance; atrioventricular discordance with double outlet right ventricle; atrioventricular discordance with double outlet left ventricle; atrioventricular discordance with a single vessel issuing from the right or left ventricle. With reference to their personal cases and those described in the literature, the authors describe the anatomy, physiopathology and the clinical consequences of the different forms encountered in their cases. The different surgical techniques for each anatomical form of this condition are discussed.

Angiocardiography↗
PubMed1983

[Assessment of the branches of the pulmonary artery by 2-dimensional echocardiography].

Sixty three cases of Fallot's tetralogy aged from 1 month to 30 years old, were studied by 2D echocardiography to evaluate the diameter of the pulmonary arteries and to detect stenosis of the main pulmonary arteries. The right pulmonary artery was visualised clearly enough to be measured in all 63 cases whereas the left pulmonary artery could only be adequately recorded in 58/63 cases. The junction of the two pulmonary arteries was confirmed by 2D echo in 61/63 cases; in two cases, the left pulmonary artery was not connected (2/63), confirmed at angiography and surgery. Six stenoses of the pulmonary arteries, confirmed surgically (6/7), were detected by 2D echo but there were also 3 false positive results. The pulmonary arteries were measured from suprasternal views; the values obtained ranged from 3 to 15 mm. There was a good correlation with the angiographic measurements (R = 0.81 for the right pulmonary, and R = 0.82 for the left pulmonary arteries). Good correlations were also observed between the peroperative and 2D echo measurements (R = 0.84 for the right pulmonary; R = 0.77 for the left pulmonary artery). 2D echocardiography is a non-invasive reliable technique for visualising the pulmonary arteries and their origin, for measuring the calibre of these vessels and for detecting severe proximal pulmonary artery stenosis.

Adolescent↗
PubMed1983

[Left coronary artery arising from the pulmonary artery. Demonstration by 2-dimensional echocardiography].

The authors report the case of a baby in whom an ectopic left coronary artery arising from the pulmonary artery was suspected on clinical and, in particular, electrocardiographic criteria. M mode echocardiography showed left ventricular dilatation with reduced shortening fraction of the LV internal diameter. 2D echocardiography with a mechanical sector scanner demonstrated the left coronary artery arising from the pulmonary artery. The short axis view of the basal vessels in the left parasternal incidence visualised 2 cm of the left coronary artery arising from the posterior part of the pulmonary artery.

Coronary Vessel Anomalies↗
PubMed1983

[Results of 108 endoscopic papillotomies].

At the Medical Clinic of the St. Elisabeth Krankenhaus, Cologne, 108 endoscopic papillotomies (EPT) were carried out between September 1977 and May 1983; 90% have been successful. Choledocholithiasis in 91 patents (84,2%) was the most frequent indication. Approximately half of the cases had had previous cholecystectomy; in the other half the still existing gall-bladder contained stones. These latter patients were definite risk-patients; their average age was 16 years above that of patients with previous cholecystectomy. Other indications have been the inflammatory (14 patients) or tumorous stenosis (3 patients) of the papilla. Complications occurred with 8 patients (7,4%); mortality-rate: 1,9%. The good results and the low rate of complications make EPT the method of choice in case of residual or recurring stones after cholecystectomy as well as in case of risk patients with existing gall-bladder and stones in the common bile duct. Further indications have been: malignant or benign papillary stenosis and acute emergency situations (acute biliary pancreatitis or cholangitis through a stone blocking the duct). The nasobiliary permanent probe, the possibility of direct litholysis, the dilatation by catheter and prolonged draining of stenosis open new applications.

Aged↗
PubMed1983

[Comparison of left ventricular function in children hemodialyzed with bicarbonate and acetate. An echocardiographic study].

Left ventricular function before and after hemodialysis with acetate (A) and hemodialysis with bicarbonate (B) was investigated in 8 children on regular dialysis treatment. The decrease in left ventricular volume overload is similar in A and B. There is a significant increase in shortening fraction (B: 9,7 +/- 16,1%; p less than 0,05. A: 7,8 +/- 10,9%; p less than 0,05), in velocity of circumferential fiber shortening (Vcf) (B: 30,6 +/- 16,5%; p less than 0,0005. A: 23,5 +/- 16,6%; p less than 0,0025) and in corrected Vcf (B: 19,3 +/- 16,4%; p less than 0,0025. A: 13,6 +/- 11,4%; p less than 0,005). The ratio of pre-ejection period with the left ventricular ejection time (PEP/LVET) is increased significatively only after hemodialysis with bicarbonate. This difference may be due to a better left ventricular function in hemodialysis with bicarbonate than with acetate.

Acetates↗
PubMed1982

SAH analogs, modified in the aminoacid region, inhibitors of phosphatidyl-ethanolamine methylase activity and 3H-SAH binding to rat brain membranes.

The study of phosphatidylethanolamine methylase inhibition by 10 SAH analogs points out the importance of the L-homocysteine amino and carboxylic groups and the sulfur atom for the activity of SAH. Besides, the inhibition of phosphatidylethanolamine methylase by SAH analogs is correlated with their affinity for the 3H-SAH binding sites on the rat cortical membranes.

Animals↗
PubMed1982

[Echocardiographic findings in children with chronic renal failure ].

Echocardiographic examinations were carried out in 2 groups of children with chronic renal failure. Group 1 consisted of 9 children who were not treated with hemodialysis. Group 2 consisted of 9 children undergoing chronic hemodialysis. Results in both groups were compared with a control group of 35 normal children. No difference was found between normal children and group 1 children. Group 2 children presented with a moderate myocardial hypertrophy and dilatation of the left atrium. Indices of contractility were also decreased. Comparison before and after hemodialysis showed no change in cardiac function.

Adolescent↗
PubMed1982

[Comparative study of left ventricular echocardiographic parameters in congenital aortic stenosis and coarctation].

Left ventricular adaptation to obstruction to ejection (aortic stenosis and coarctation) was studied by echocardiography in 85 patients from 1 month to 20 years of age. Group I: 40 children with pure congenital aortic stenosis. Group II: 45 children with coarctation at the aortic isthmus without associated shunts. All patients also underwent cardiac catheterisation. The results were compared with a control series of 35 normal subjects. Echocardiographic recordings of adequate quality for studying the left ventricle and parameters of myocardial performance were obtained in all patients. In Group I estimations of the left ventricular systolic pressure and the ventriculo-aortic pressure gradient were made and compared to the results of catheterisation. Symmetric left ventricular hypertrophy was recorded in both groups (h/R, p less than 0,001; myocardial mass, p less than 0,001) but this was more common in aortic stenosis (92%) than in coarctation (53%). Left ventricular function was similar in both groups with an increased fractional shortening (p less than 0,001) and velocity of circumferential fibre shortening (p less than 0,001). Good correlations were obtained between echocardiographic and hemodynamic measurements of left ventricular pressures and ventriculo-aortic pressure gradients (pressure R = 0,83, gradient R = 0,73) using the formula for systolic left ventricular pressure = SLV = 225 X PPs/Ds. This proved very useful in assessing which children needed surgery.

Adolescent↗
PubMed1981

[Affinity of tritiated S-adenosyl-L-homocysteine for membrane preparations from various parts of rat the rat brain].

The study of tritiated S-adenosyl-L-homocysteine binding in various areas of the Rat brain has shown that the affinity was the same in the different regions whereas the number of binding sites was greater in the hippocampus and in the cerebellum than in the cortex, the corpus striatum, the mesencephalon, the hypothalamus and the brainstem. The phosphatidylethanolamine-N-methylase activity was also greater in the hippocampus and in the cerebellum.

Animals↗
PubMed1981

Pharmacokinetics and metabolism of [14C]ursodeoxycholic acid in the rat.

The pharmacokinetics and metabolism of [14C]ursodeoxycholic acid have been studied after intravenous and intraduodenal administrations of tracer doses to bile fistula rats. Control animals were fed a standard diet. Two other groups received the same diet added with UDCA (5 mg/kg body wt. per day) (group A) or (20 mg/kg body wt. per day) (group B) for 3 weeks. The plasma clearance in control and treated animals after intravenous injection of [14C]UDCA (2 microCi. 20 microgram) followed an identical biphasic exponential curve with t 1/2 of 2 and 30 min, respectively. Biliary excretion kinetics were dependent on the treatment; after 10 min of injection, the recovery of radioactivity in bile was 29.8, 19 and 10.9% in group B, A and control, respectively. After intraduodenal administration, the same dose of [14C]UDCA, was rapidly absorbed and excreted in bile. The kinetic process was modified by treatment; at the 30-min peak of radioactivity, the fraction of the dose excreted in bile was: controls, 51.2%; group A, 32.8% and group B, 35.3%. Biotransformation of [14C]UDCA after intravenous and intraduodenal administrations was similar in the three groups. Radioactivity was mainly found as the tauroconjugate of UDCA and less than 5% 14C was recovered as beta-muricholic acid. Bile composition was modified by the UDCA diet as follows: biliary bile acids increased and cholesterol decreased proportionally to the dose; the relative ratio of biliary bile acids was changed, UDCA represented at most 7% in the group B.

Animals↗
PubMed1981

[Early PEEP for improvement of prognosis in patients with acute respiratory insufficiency (author's transl)].

One hundred twenty-seven artificially ventilated patients with acute respiratory insufficiency (ARI) were investigated. In 61 patients positive endexpiratory pressure (PEEP) was used when ventilation with ZEEP proved to be insufficient for one or more of the following reasons: increasing I-aDO2m PaO3 below 60 Torr at FiO2 greater than or equal to 0.5, deterioration of clinical status (group = secondary PEEP). The time elapse between beginning of artificial ventilation and institution of PEEP was 46 +/- 47 h (median 33 h). In 66 patients PEEP was used from the beginning of artificial ventilation (group II = primary PEEP). The distribution of underlying diseases (severe poisoning, pancreatitis, polytrauma or major surgery, pneumonia, cardiovascular failure, sepsis) as well as the frequency of additional vital function failure (circulatory shock, acute renal failure) were comparable in both groups (p greater than 0.05). At the beginning of artificial ventilation both groups were comparable in respect to respiratory insufficiency. PaO2 was 75 +/- 26 Torr in group I and 70 +/- 29 Torr in group II at comparable levels of FiO2 (p greater than 0.05). PaCO2 was 34.7 +/- 8.2 Torr in group I and 37.4 +/- 10.5 Torr in group II. Significantly more patients in group II received corticosteroids (greater than 1 gr/die). Mortality was 48/61 (79%) in group I and 37/66 (56%) in group II (p less than 0.01). End-inspiratory pressure exceeding 35 cm H2O was necessary in 42/61 patients in group I and 28/66 patients in group II (p less than 0.01) and FiO2 greater than 0.5 was necessary to keep PaO2 above 60 Torr in 39/61 patients in group I and 27/66 patients in group II (p less than 0.01). It is concluded that early institution of PEEP improves the course and outcome of patients with ARI.

Acute Disease↗