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Biomedical subjects

C Rey

Publications and source records attributed to C Rey.

At least 325 records · Page 18Linked to original sources
PubMed1986

[Double superior vena cava with drainage of the right superior vena cava into the left auricle. Presentation as a cerebral abscess in an adult].

A 44 year old man presented with a cerebral abscess, the location of which suggested a septicaemic origin. Although the patient was not cyanosed, a cardiological work-up was requested to exclude a right-to-left shunt. This showed a double abnormality of the systemic venous drainage: presence of an abnormal left superior vena cava draining into the coronary sinus and of a right superior vena cava draining into the left atrium. These two vena cava intercommunicated by anastomoses. Angiography in the right superior vena cava after occlusion by balloon catheter at its junction with the left atrium showed flow from the right to the left superior vena cava and to the azygos system. Simple ligature of the right superior vena cava was therefore performed to prevent recurrence of cerebral abscess. This case is rare and of interest because of the presence of two superior vena cavae, one on the right draining into the left atrium and the other on the left draining into the coronary sinus, with anastomoses between the two superior vena cavae. This double abnormality of systemic venous drainage explains the absence of cyanosis and therefore the relatively late detection of this malformation.

Adult↗
PubMed1985

Percutaneous balloon angioplasty in an infant with obstructed total anomalous pulmonary vein return.

This is a report of successful dilation of stenosis of the common trunk in a case of total anomalous pulmonary vein return into the left superior vena cava in a 3 month old infant. Percutaneous angioplasty was performed with a 6 mm diameter balloon catheter. Right ventricular systolic pressure decreased from 96 to 60 mm Hg, mean pulmonary vein pressure decreased from 26 to 14 mm Hg and left ventricular systolic pressure increased from 70 to 90 mm Hg.

Angioplasty, Balloon↗
PubMed1985

Phospholipid methylase activity, [3H]S-adenosyl-L-homocysteine binding, and S-adenosyl-L-methionine and S-adenosyl-L-homocysteine levels in rat brain during maturation.

The changes in activity of phospholipid methyltransferase I and [3H]S-adenosyl-L-homocysteine ([3H]SAH) binding were determined in cortical membrane preparations from newborn rats and rats 1, 2, and 8 months old. The activity of phospholipid methyltransferase I and the [3H]SAH binding were significantly greater (respectively, +30 and +40%) in newborn rats than in 1-, 2-, and 8-month-old rats. The methylated products at days 1 and 30 were identical. These changes in methyltransferase activity may be correlated with variations in concentration of S-adenosyl-L-methionine (SAM) and SAH. The endogenous SAM level was higher and the SAH level was lower in newborn compared with adult rats. These data suggested that the processes of methylation were favored in newborn rats. The modifications observed after treatment with L-homocysteine reinforced this hypothesis.

Animals↗
PubMed1985

[Phosphatidylethanolamine methylase and cyclic nucleotide phosphodiesterase activities in human B lymphoid hemopathies].

Phospholipid methylase and cyclic nucleotide phosphodiesterase activities were studied in human B lymphoïd hemopathies (51 patients: acute lymphoblastic leukemia, B lymphoma, chronic lymphocytic leukemia, hairy cell leukemia) and compared with activities in lymphoblastïd and Burkitt lymphoma cell lines and with normal B lymphocytes: methylase activity proved to be lower in ALL and high grade lymphoma and inversely related to the percent of cells in S phase state; the A/G ratio of phosphodiesterases was low in ALL and CLL and high in hairy cell leukemia and it was related to the percent of cells in S phase state.

3',5'-Cyclic-AMP Phosphodiesterases↗
PubMed1985

[Percutaneous transluminal valvuloplasty in pulmonary stenosis. Apropos of 24 cases].

Twenty-four patients with moderate or severe valvular pulmonary stenosis were treated by percutaneous transluminal valvuloplasty (PTV). The age of the patients ranged from 24 hours to 27 years. Eighteen patients (group I) had a right ventricle-pulmonary artery (RV-PA) pressure gradient greater than 50 mmHg (measured simultaneously or during catheter withdrawal). Six patients (group II) had RV-PA pre-sure gradients of less than 50 mmHg. Twenty-seven PTV procedures were performed. Six of the 24 patients were under 2 months of age, including 4 who were less than 1 week old. The youngest patient (under 24 hours old) had valvular pulmonary stenosis, very nearly atresia. PTV was carried out using Rashkind's technique on 2 occasions and with a dilatation catheter with a balloon of 6 to 20 mm of diameter on the other 25 occasions. In 6 cases, 2 dilatation catheters were introduced and inflated simultaneously in the pulmonary valve. The overall results were satisfactory: RV pressure fell from 87.6 to 54.4 mmHg, the RV-PA gradient from 72.3 to 31.9 mmHg and the ratio of RV/systemic pressure from 104.4 to 51.1. The improvement was more marked in group I than in group II. The causes of failure are discussed: valvular dysplasia, severe infundibular hypertrophy, inadequate diameter of the balloon. Tolerance of PTV was very good. The value of this procedure is emphasised. It may save surgical valvotomy in high risk groups of patients, such as the newborn and infants. The haemodynamic results of PTV are maintained at long-term, but the number of cases is still too small.

Adolescent↗
PubMed1985

[Ischemia of the cecum caused by glycylpressin].

A case report is given of a patient with severe upper gastrointestinal bleeding, the source of which could not be localized immediately. Glycylpressin (GP) was applied since bleeding from esophageal varices was suspected. During surgery a gastric ulcer was found penetrating into the pancreas and eroding the splenic artery. A segmental ischemic necrosis of the coecum was found as well, - a complication not yet reported after use of GP. Problems of using GP as a therapeutic agent and especially intestinal necrosis as a complication are discussed. The patient had gastrectomy, splenectomy and hemicolectomy and recovered well.

Cecum↗
PubMed1985

[Two-dimensional echocardiography of coronaro-cavitary fistulas].

4 cases of congenital coronary arteriovenous fistulae in children 20 days to 10 years old were studied by 2D echocardiography. The coronary fistulae were treated surgically in all four cases after biplane aortography and selective coronary arteriography. The visualisation of the coronary arteries was performed by systematic use of several echocardiographic views: - left parasternal short axis view through the aortic root, - apical view, - longitudinal and transverse subcostal views. 3 cases of coronary fistulae between the right coronary artery and a cardiac chamber were diagnosed on the basis of significant dilatation (9 to 12 mm) of the right coronary artery, though the origin and diameter of the left coronary artery were normal. 1 case of a fistulae from a single left coronary artery was not diagnosed despite the demonstration of dilatation of the left main stem. Conversely, there were no false positive 2D echocardiographic diagnoses during the study period. The communication of the coronary fistula to the receiving cardiac chamber was demonstrated in two cases (right atrium: 1 case, left atrium: 1 case, on apical and subcostal views. It was not possible to visualise the communication of the coronary fistula with the right ventricle in the other two cases. 2D echocardiography is a non-invasive method of diagnosing coronary arteriovenous fistulae, but the development of a fistula on a single left coronary artery is a potential source of diagnostic error.

Angiography↗
PubMed1985

[Membrane phosphatidylethanolamine methylase in blood leukocytes and alveolar macrophages of asthmatic patients].

Phosphatidyl ethanolamine methylase (PEMT) is an enzyme involved in the methylation of membrane phospholipids which plays a very important role in the modulation of the activity of the beta-receptors and the production of phosphatidylcholine, substrate of phospholipase A2. This report describes a study of PEMT on the membranes of blood leucocytes and alveolar macrophages obtained by bronchoalveolar washings in different types of asthma: allergic, intrinsic and occupational. This was accompanied by parallel study of respiratory function tests and the level of bronchial reactivity to carbachol in asthma sufferers as well as other alveolar biological parameters: phospholipid fractions of surfactant, angiotensin conversion enzyme and protein/albumin ratio. The authors found a significant increase (in comparison with controls) in PEMT activity both in macrophages and leucocytes in cases of intrinsic asthma. However, there was no correlation between the level of activity of the enzyme and the degree of bronchial hyper-reactivity. There was no change in alveolar phospholipid environment. In the light of these findings, the role of membrane activation of the alveolar macrophage is discussed in the physiopathology of intrinsic asthma.

Adult↗
PubMed1984

[Use of intraluminal dilatation catheters in the surgical treatment of pulmonary atresia with intact septum].

Despite considerable progress in surgery and intensive care and the advent of prostaglandins, pulmonary atresia with intact ventricular septum remains a severe heart disease. The authors describe a technique of pulmonary valve plasty across the right ventricule, using dilatation balloon catheters for peripheral arteries. This technique proved successful after a 4 to 12 months follow-up in 2 out of 4 neonates who underwent surgery. It is fast, causes little damage to the right ventricle and could be improved by using catheters specifically designed for this type of surgery.

Angioplasty, Balloon↗
PubMed1984

[Solubilization of cerebral binding sites of S-adenosyl-L-homocysteine].

We describe the solubilization of S-adenosyl-L-homocysteine binding sites from rat brain membranes; Triton X100 could solubilize near 50% of the sites. The solubilized extract exhibited the same pH dependence as the membrane extract and had the same dissociation constant and the same sensibility to S-adenosyl-L-methionine and adenosine. The solubilized extract exhibited a methylase activity which accepted phosphatidylethanolamine as substrate.

Animals↗
PubMed1984

[Demonstration of a new methylase in cell membranes of rat brain].

In Rat brain membranes, two methylases occurred which converted phosphatidylethanolamine to phosphatidylcholine. We have pointed out another methylase which gave chloroform extractable methylated products; its Km was nearly 10 fold lower than that of the other methylases.

Animals↗
PubMed1984

[2-dimensional echocardiographic diagnosis of an intracardiac thrombus in children].

Eight cases of intracardiac thrombi in infants and children were compiled in a cooperative study involving five paediatric cardiological centres. Two babies were hospitalised for cardiac failure due to a severe supraventricular arrhythmia. Two-dimensional echocardiography (2D echo) showed a left atrial thrombus which disappeared after anticoagulant therapy. The third case was unusual: 2D echo performed 4 months after a Senning operation for complete transposition of the great arteries showed stenosis of the pulmonary venous canal and a thrombus above the stenosis: the mass was echogenic, rounded, of variable density and in contact with the pulmonary veins. These findings were confirmed at autopsy. The fourth case was a 34 month old child with Fallot's triad in whom 2D echo showed a right ventricular thrombus, confirmed at surgery. The four remaining cases were thrombi detected in patients with congestive cardiomyopathy. The thrombus was adherent to the left ventricular lateral wall or apex. Two of these thrombi disappeared after anticoagulant therapy, one of which after hemiplegia. 2D echo is a useful tool for the diagnosis and surveillance of intraatrial or intraventricular thrombi. Intraatrial thrombi may be due to supraventricular arrhythmias in children; intraventricular thrombi are usually seen in association with poor left ventricular contractility. The diagnosis of thrombosis should lead to institution of anticoagulant or even fibrinolytic therapy in order to avoid systemic embolism.

Adolescent↗
PubMed1984

[2-dimensional echocardiography of congenital obstruction of left ventricle inflow. Apropos of 25 cases].

Twenty-five cases of left ventricular inflow obstruction in children aged 4 months to 11 years were investigated by two-dimensional echocardiography and cineangiography. The results of 2D echo were compared with the operative appearances in 15 cases and the pathological findings in three cases. This series included 5 cases of cor triatrium and 20 of congenital mitral stenosis, 3 of which were associated with a supramitral ring. Abnormalities of the mitral papillary muscles were the main cause of congenital mitral stenosis in this series (12 cases); there were 6 cases of single papillary muscle and 6 cases with two closely situated or fused papillary muscles. These abnormalities of the mitral papillary muscles were demonstrated on the transverse left ventricular views obtained from the parasternal or subcostal regions. All the papillary muscle abnormalities diagnosed by 2D echo were confirmed at autopsy or surgery. Cases of mitral stenosis due to short and thickened chordae were demonstrated on parasternal long axis views. Hypoplasia of the mitral ring was visualised on long axis or apical views. The supramitral ring was demonstrated on the parasternal long axis or apical four chamber views, as an abnormal echo situated just above the mitral valve in the left atrium. All three cases in this series were correctly diagnosed by 2D echocardiography. Nineteen of the 20 congenital mitral stenoses were associated with other cardiac malformations (14 coarctations of the aorta, 9 aortic stenoses, 4 ventricular septal defects) which were also detected by 2D echocardiography.

Child↗
PubMed1984

[Coarctation of the aorta and Fallot's tetralogy. Apropos of 2 cases].

Two cases of the association of Fallot's tetralogy and coarctation of the aorta are reported. In both cases there was a right aortic arch. In addition, the second case had a cervical aorta and a left subclavian artery isolated from the aorta and vascularised by the left vertebral artery. The two children underwent complete repair: the first patient had a Waterston shunt followed by repair of the Fallot's tetralogy, followed by repair of the coarctation; the second patient first had a Gore-tex tube inserted from the ascending to the descending aorta and then underwent repair of the Fallot's tetralogy. The association of a coarctation with an obstructive lesion of the right heart is very rare; only two cases have previously been reported: one Fallot's tetralogy and one tricuspid atresia with pulmonary stenosis. Both cases also had a right aortic arch. This seems to go against the haemodynamic theory of coarctation: blood flow in the ascending aorta increases while flow in the pulmonary artery decreases. Coarctation could be caused by a partial involution of the terminal segment of the right primitive dorsal aorta as proposed in cases of coarctation with a right sided aortic arch. The second case also presented two uncommon features: a cervical aortic arch and a left subclavian artery isolated from the aorta.

Aortic Coarctation↗