Search PubMed⌕ Search

Biomedical subjects

C Morin

Publications and source records attributed to C Morin.

At least 127 records · Page 7Linked to original sources
PubMed1986

[Simplified technic for extemporaneous femoral lengthening in children].

Since 1981, twenty five "simplified" one stage femoral lengthening operation have been performed. This procedure using a transverse osteotomy and direct instrumental spreading seems to be, for the authors, as safe and easier than one stage femoral lengthening using a step osteotomy first described by Cauchoix in 1963. Patients were aged from 2.8 to 19. Mean operative gain was 34 mm. Duration of bony union with full weight bearing range between two and three months. One septic non union and two early breakage of the internal fixation have been observed.

Adolescent↗
PubMed1985

The infant hip: real-time US assessment of acetabular development.

Until recently, radiography was the only available means of assessing acetabular development in infants with congenital hip dysplasia. Now that real-time ultrasonography (US) is successfully employed to determine hip position in infancy, it also offers an alternative method for evaluating acetabular development. In a review of 377 US studies of infant hips, the coronal-flexion images, which show a coronal section of the acetabulum with the hip in flexion, were measured to determine the percentage of the femoral head that was covered. Radiographs were measured to determine the acetabular index (angle). Acetabuli with indices exceeding the normal range for the subject's age showed head coverage of less than 33%. The 51 sonograms in this category were all associated with clinical abnormalities, whereas the 107 with coverage greater than 58% were associated with no clinical abnormalities and with consistently normal acetabular indices. The use of US in assessing acetabular development warrants continued investigation.

Acetabulum↗
PubMed1984

Evidence for presynaptic inhibition of muscle spindle Ia afferents in man.

A new method for estimating presynaptic inhibition of soleus (Sol) Ia fibres in man is introduced based on the assessment of the amount of facilitation produced by a preceding homonymous Ia volley onto a Sol monosynaptic reflex. It was found in animal experiments that a reduction of such Ia facilitation reflects the amount of presynaptic inhibition exerted on these Ia fibres. Since, in man, a similar reduction of homonymous Ia facilitation was found after tibialis anterior vibration, this provides evidence for presynaptic inhibition of Sol Ia fibres, elicited here by the afferent discharge due to this flexor vibration.

Adult↗
PubMed1984

Sensory nerve conduction in chronic uremic patients during the first six months of hemodialysis.

In an attempt to find the best electrophysiological indicator of improvement for the neuropathy present in patients with chronic renal failure undergoing hemodialysis, several types of nerve conduction were studied at the beginning of dialysis and six months later. Sural nerve conduction and late response latencies were recorded in addition to conventional motor and sensory nerve conductions. After six months of hemodialysis, sensory nerve conduction velocities in the median, ulnar and sural nerves were improved. These values appear to be the most sensitive indices of the beneficial effect of hemodialysis on the neuropathy.

Adult↗
PubMed1984

Cellular retinol- and retinoic acid-binding proteins in the epidermis and dermis of normal human skin.

The distribution of cellular retinol- and retinoic acid-binding proteins (CRBP and CRABP) in normal human epidermis and dermis was examined by gel filtration. We showed that CRBP is entirely bound to a lipid-protein aggregate and its free form is obtained through delipidation. The type of homogenization procedure appeared to be important for the recovery of CRBP in human skin. The level of CRABP was about 3.1 pmol/mg protein in the epidermis whereas it was only sporadically detectable in the dermis. In contrast, CRBP was found in both tissues at a concentration of about 1 pmol/mg protein. The difference in CRABP concentrations between epidermis and dermis might have biological and therapeutic implications. Dissociation constants (Kd) of CRABP and CRBP were respectively 2.2 X 10(-7) M and 2.51 X 10(-7) M. This method will facilitate the study of CRABP and CRBP in retinoid- responsive dermatoses and enable us to relate the therapeutic effects of retinoids to the levels of cellular retinoid-binding proteins in the skin.

Adult↗
PubMed1984

[Lumbar stenosis with scoliosis. Symptomatologic study and surgical treatment of 39 cases].

In 39 cases of narrowed lumbar spinal canal associated with a scoliosis, the authors have studied the role played by deviation of the spine and the origin of the narrowing. It seemed that central stenosis with intermittent claudication was more frequent when a scoliosis was present. In more than half of the cases, the level of the compression was at the junction of the curves. After failure of conservative treatment, the surgical procedure performed was the same as in straight spines. The results were satisfactory in 90 p. 100 as regards root involvement and intermittent claudication. However 7 patients had increased low back pain after surgery, 3 of them being disabled. In young patients with curves of more than 30 degrees with noticeable rotation, straightening with arthrodesis appeared to be worthwhile rather than simple posterior laminectomy. In other cases a posterior liberation of the cord associated with limited posterolateral fusion is indicated.

Follow-Up Studies↗
PubMed1983

Detection of sickle cell beta S-globin allele by hybridization with synthetic oligonucleotides.

Two 19-base-long oligonucleotides were synthesized, one complementary to the normal human beta-globin gene (beta A) and one complementary to the sickle cell beta-globin gene (beta S). The nonadecanucleotides were radioactively labeled and used as probes in DNA hybridization. Under appropriate hybridization conditions, these probes can be used to distinguish the beta A gene from the beta S allele. The DNA from individuals homozygous for the normal beta-globin gene (beta A beta A) only hybridized with the beta A specific probe; the DNA from those homozygous for the sickle cell beta-globin gene (beta S beta S) only hybridized with the beta S specific probe. The DNA from heterozygous individuals (beta A beta S) hybridized with both probes. This allele-specific hybridization behavior of oligonucleotides provides a general method for diagnosis of any genetic disease which involves a point mutation in the DNA sequence of a single-copy gene.

Alleles↗
PubMed1982

Comparison of soleus H reflex facilitation at the onset of soleus contractions produced voluntarily and during the stance phase of human gait.

Variations in the soleus monosynaptic reflex have been studied in normal human subjects during soleus contractions while walking, and compared with those observed during voluntary soleus activation. The monosynaptic reflex was always more facilitated during voluntary contractions than during walking. The EMG activity was identical in both situations. Under the assumption that this reflects an identical excitability of the motoneuronal pool, this different soleus H-reflex facilitation can be attributed to a difference in the excitatory efficiency of the group I volley evoked by the H-reflex stimulation. It is suggested that the level of presynaptic inhibition exerted on Ia fibers could be lower during walking than during voluntary contraction.

Ankle↗
PubMed1982

Reinforcement procedure in the treatment of reluctant speech.

The efficacy of a positive reinforcement contingency procedure was evaluated in the treatment of a 6-year old boy with reluctant speech. The intervention was conducted in the kindergarten classroom and the teacher served as therapist. Using an ABABB' single case experimental design, positive reinforcement was found to be effective for increasing the child's verbal responsiveness. At a 1-year follow-up, therapeutic benefits were maintained at an optimal level. The present results bring support to the use of reinforcement procedures in the case of reluctant speech.

Behavior Therapy↗
PubMed1982

Oligonucleotide-directed mutagenesis as a general and powerful method for studies of protein function.

We have used oligonucleotide-directed mutagenesis to make a specific change in the beta-lactamase (EC 3.5.2.6) (ampicillin resistance) gene of the plasmid pBR322. Evidence suggests that the active site for this enzyme may include a serine-threonine dyad (residues 70 and 71). By priming in vitro DNA synthesis with a chemically synthesized 16-base oligodeoxyribonucleotide, we have inverted the Ser-Thr dyad to Thr-Ser and thereby generated a mutant with an ampicillin-sensitive phenotype. This "double-mismatch" method is relatively simple and also very general because detection of mutants is at the level of DNA and involves only colony hybridization. Accordingly, the procedure can be applied to any DNA sequence and does not depend on the phenotype of the mutant.

Amino Acid Sequence↗