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Biomedical subjects

C Morin

Publications and source records attributed to C Morin.

At least 145 records · Page 8Linked to original sources
PubMed1981

Biological variations in hyperlipidemic children and adolescents treated with fenofibrate.

Beside their pharmacological action drugs may have unexpected side effects which must be known and taken into account in the interpretation of laboratory tests. In this work, we followed 17 hyperlipidemic subjects, aged 4-19 years, treated with fenofibrate only. We performed several plasma tests before and during treatment. The hypolipidemic action of fenofibrate was evident: decreases of cholesterol and triglycerides mean values were, respectively, 22% and 39% after 3 months of treatment. Other plasma constituents were also significantly decreased: uric acid, 20%; bilirubin, 19%; alkaline phosphatases, 15%. The aminotransferase activities (both AST and ALT) were increased in only four subjects after 3 months. The highest values were 88 U/l for AST and 109 U/l for ALT (the initial values were, respectively, 28 U/l and 23 U/l). These activities decreased when the treatment was stopped. These variations were isolated and transient.

Adolescent↗
PubMed1981

Pattern of group I fibre projections from ankle flexor and extensor muscles in man.

Variations in the H-reflex of soleus, tibialis anterior, quadriceps and short head of biceps femoris muscles were studied in normal man, preceded by a conditioning stimulus applied to either gastrocnemius medialis, the inferior branch of soleus or the common peroneal nerve. The observed variations were evoked by low threshold afferents, had a very short latency suggesting oligosynaptic linkage and disappeared during a selective ischaemic blockade of group I fibres; they were therefore regarded as due to group I fibre stimulation. Biphasic variations were observed in almost all cases: evidence is presented that the early low threshold effects, facilitatory for synergistic and inhibitory for antagonistic motoneurone pools, are due to stimulation of Ia fibres, while the subsequent opposite effects which had a slightly higher threshold are Ib in origin. Even though the pattern of projections of group I fibres from ankle flexors and extensors is qualitatively the same in normal man as in the spinal cat, large quantitative differences are observed; in normal man the effects of group I fibres from ankle flexors and extensors upon close synergistic and direct antagonistic motoneurone pools are weak, and often negligible, whereas they are extremely potent upon quadriceps motoneurones.

Adult↗
PubMed1981

Cutaneous depression of Ib reflex pathways to motoneurones in man.

Variations in the H-reflex of soleus (Sol), quadriceps (Q) and short head of biceps femoris (Bi) muscles in normal man were used to investigate the effect of volleys in low threshold cutaneous afferents from the ipsilateral limb on transmission of Ib effects from ankle and Q muscles to these different motoneurone (MN) pools. Stimulation of cutaneous afferents from the foot sole and the toes (but not from the thigh, knee or calf), which did not modify the size of the test reflexes when applied alone, strongly depressed Ib reflex pathways to MNs supplying muscles operating at the knee. The very brief central latency of this depression suggests that tactile cutaneous afferents from the foot have oligosynaptic spinal connexions with the interneurones intercalated in the Ib pathways to MNs. The same cutaneous stimuli did not all modify Ib inhibition of Sol MNs from triceps surae. These findings are discussed with regard to the role of the different muscles in human locomotion. It is suggested that during the stance phase of heel bipedal locomotion, the cutaneous depression of Ib reflex pathways to MNs supplying muscles operating at the knee might operate in association with the strong Ia connexions from ankle to knee muscles described in the previous paper.

Adult↗
PubMed1981

Identification of an H-2Kb-related molecule by molecular cloning.

Based on the published amino-acid sequence of H-2Kb, we synthesized a mixture of eight 16-base long oligodeoxyribonucleotides representing all possible coding sequences for residues 51-56 (Trp-Met-Glu-Gln-Glu-Gly). The hexadecanucleotide mixture was used as a probe to screen recombinant DNA clones constructed from cytoplasmic PolyA+ RNA isolated from the murine thymoma cell line EL4(b haplotype). Of the 30 000 independent clones screened, one clone was found to hybridize with the probe. DNA sequence analysis showed that the cDNA clone was derived from a portion of an H-2Kb -related mRNA. The clone encodes a protein sequence identical with a region of H-2Kb in 42 consecutive residues (50 through 91). The sequence than diverges from the H-2Kb sequence and, after a single Glu codon, a termination codon is encountered. It is possible that this mRNA codes for a small 92 amino-acid protein with a sequence identical (except for a carboxy-terminal Glu residue) with the amino terminus of H-2Kb. It is further speculated that this mRNA is coded for by the H-2Kb gene and differs from the H-2Kb mRNA in the pattern of posttranscriptional splicing.

Amino Acid Sequence↗
PubMed1981

Vaginal condylomata: a human papillomavirus infection.

In our clinic, as a rule, we do not treat vaginal condylomata. They are usually subclinical and asymptomatic. When atypia is present on biopsy, they should be treated in the same manner as vaginal intraepithelial neoplasia. When vaginal discharge and pruritus are present, infection should be searched for and treated. When condylomata are seen with the naked eye, colposcopy has shown that there were many more, too small to be seen, so that local therapy seems a waste of time. If on colposcopic examination only a few condyloma acuminata are located, then therapy is defendable. CO2 laser therapy should be preferred to other modalities until a systemic treatment is available and safe.

Animals↗
PubMed1981

Depression and sickle cell anemia.

Very few reports of depression occurring with sickle cell anemia have been documented. We have reported three cases of depression in patients with sickle cell anemia that were referred over a relatively brief period, and that were successfully treated with antidepressant medication and family therapy. We examined possible mechanisms of depression, and concluded that depression may accompany sickle cell anemia more commonly than previously suspected.

Adult↗
PubMed1981

Correction for nonlinearity of body flow plethysmograph.

A modification of conventional signal processing for the pressure-compensated flow plethysmograph is proposed to correct the nonlinearity of the flow element that appears for high flows as encountered during forced expiration. Woven screens behave as porous media with a viscous and an inertial component in the resistance; this explains the nonlinearity (23% at 15.1.s-1 with a 400-mesh wire screen area = 50 cm2). It was shown that the pressure drop-flow relationship can be described by a second-degree equation, which can be included in the computation of the thoracic signal from the box pressure. The need for such a correction is evidenced by testing the plethysmograph with a flow step input (0-15 l.s-1) equivalent both in amplitude and in frequency to the thoracic flow during a forced expiration. Such correction for nonlinearity avoids an overestimation of the thoracic forced vital capacity of up to 0.5 liter in normal subjects.

Humans↗
PubMed1981

[Therapy through activity according to A. C. Mosey (description and application).].

This article describes Anne Cronin Mosey's theory of "Activities Therapy". What it is, by whom it can be practiced and how she views psychosocial dysfunction is briefly portrayed. A more elaborate description of the theoretical concepts such as Basic Skills, Public Self and Private Self are presented. The application of this theory and its use is brought forward by the occupational therapists of the "Ateliers centraux" of the Occupational Therapy Department of "Centre hospitalier Louis-Hippolyte Lafontaine".

English Abstract↗
PubMed1981

Confirmation of the papillomavirus etiology of condylomatous cervix lesions by the peroxidase-antiperoxidase technique.

The peroxidase-antiperoxidase technique with the use of paraffin sections of 67 cervical biopsy specimens and an antiserum cross-reactive with all papillomaviruses provided immunologic confirmation for the observation that papillomavirus infection of the cervix is not uncommon and that it most often presents as a flat, colposcopically unremarkable lesion. Papillomavirus antigen was detected in 21 or 35 condylomata of the cervix. Antigen-positive nuclei were found in the upper layers of the epithelium. Electron-microscopic examination of five reprocessed antigen-positive sections revealed, in each instance, papillomavirus particles in the nuclei of the most superficial layers of the condylomatous epithelium. The viral antigen was not detected in dysplasia, carcinoma in situ, or invasive carcinoma.

Animals↗
PubMed1980

[Selective arterial embolization for haemorrhages complicating hip surgery. One case (author's transl)].

In a patient undergoing re-operation on the hip, the severity and repetition of haemorrhages despite successive blood transfusions led to therapeutic angiography. Angiography of the renal artery pinpointed the bleeding areas: pools of extravasated blood were found along the distal branches of the superior gluteal artery and the ascending branch of the posterior circumflex artery. Selective catheterization and embolization of these two vessels resulted in complete and permanent haemostasis. Arterial embolization, already widely used for post-traumatic haemorrhages, can therefore be applied to the haemorrhagic complications of orthopedic surgery. Provided it is sufficiently selective, the risks of extensive necrosis are non-existent.

Aged↗
PubMed1980

[Crossed plantar extension. A clinical and physiological study (author's transl)].

A 44 year-old man was examined for a slowly progressive left hemiplegia predominating on the lower limb. A left sign of Babinski was present. On the right side the plantar response was flexor. Stimulation of the right sole elicited a left extensor plantar response. CT Scan showed calcification sin the right paracentral lobule. The variations of the contralateral soleus H reflex when conditioned by a nociceptive stimulus applied on the right little toe were studied. No modification was seen. This contrasts with the facilitation observed in normal subjects and in patients with a lesion of the cerebral hemisphere not involving the paracentral lobule. It is suggested that this abnormality could contribute to the development of a crossed extensor plantar responses. Possible mechanisms of this phenomenon are briefly considered.

Adult↗