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Biomedical subjects

C Keller

Publications and source records attributed to C Keller.

At least 343 records · Page 19Linked to original sources
PubMed1976

[Sjögren's syndrome with pulmonary fibrosis. A case report (author's transl)].

The case is pointing to two remarkable facts: 1. Sjögren's syndrome may also be proceeding--without demonstrating any inflammatory rheumatic symptoms--with an isolated pulmonary fibrosis, as it had been evident in another case mentioned. 2. In certain circumstances, it may be considerably difficult to differentiate, with reliable certainty, the morphological changes in the salivary gland from those of a malignant lymphoma. Besides, also in literature there are reports concerning malignant degeneration turning into malignant lymphomata [1,8] in cases of Sjögren's syndrome.

Adult↗
PubMed1976

[Treatment of hypercholesterolemia with beta-pyridylcarbinol. Experiences after long term treatment over 8 years (author's transl)].

78 patients with hypercholesterolemia were treated with beta-pyridylcarbinol from 1964 to 1966. In 1972 42 patients could be contacted again, 37 of them were reexamined. 14 of these 42 patients were still taking beta-pyridylcarbinol in 1972. Those who had taken more than 0.9 gm per day had a lower serum cholesterol level than in the beginning of the treatment in 1964. Clinical signs of atherosclerosis (angina pectoris and peripheral arterial disease) were significantly less in this group of patients. Besides a few flush reactions or heartburn no side effects to treatment were noted. The two groups of patients, with whom the 14 were compared, included 9 who had been taking clofibrate since 1966 and 19 patients without drug treatment for hypercholesterolemia. Both groups had higher serum cholesterol levels than the group of 14 with beta-pyridylcarbinol treatment over 8 years.

Angina Pectoris↗
PubMed1976

[Treatment of hyperlipidaemia. A comparison of the efficacy of clofibrate and beta-pyridylcarbinol (author's transl)].

64 patients with hyperlipidaemia, 13 of them with pure hypercholesterolaemia, were assigned to one of three pre-determined treatment regimes over a period of seven months. Two different commercial preparations of clofibrate and one preparation of beta-pyridylcarbinol were each given for two months separated by placebo periods of two weeks. All three drugs were equally effective against increased cholesterol levels. The two clofibrate preparations lowered increased triglyceride levels more reliably than beta-pyridylcarbinol.

Cholesterol↗
PubMed1976

[Treatment of hyperlipemia and hyperuricemia with 2-acetamidoethyl-(4-chlorophenyl)-(3-trifluoromethylphenoxy)-acetate (halofenate), a derivative of clofibrate].

23 patients with hyperlipidemia and hyperuricemia received acetamidoethyl-(4-chlorophenyl)-(trifluoromethylphenoxy)-acetate (halofenate), a clofibrate derivative, and probenecid or probenecid and placebo over 36 weeks following a placebo period of 6 weeks. Halofenate compared with probenecid lowered elevated serum uric acid levels satisfactorily to a therapeutic level between 5 and 6 mg/100 ml. Serum triglyceride levels were not always lowered sufficiently, serum cholesterol levels were not influenced.

Cholesterol↗
PubMed1969

Discrete-trial alternation in the rat.

The acquisition and maintenance by rats of single alternation, double alternation, and four other repeating patterns of reinforced and non-reinforced trials was studied in a discrete-trial lever-pressing situation. The rats learned all these patterns in a small number of experimental sessions. Single alternation was learned more rapidly than the more complex patterns. Rate of learning single and double alternation decreased moderately as inter-trial interval increased. Abrupt changes in the scheduling of trials, either by doubling the inter-trial interval or by shifting from fixed to variable trial spacing, temporarily disrupted the patterned performance. Two hypotheses concerned with the means by which the rats could have learned to conform to the pattern were examined: (1) "timing" of the interval between successive reinforcements; and (2) control of responding on a trial by the outcome of preceding trials, depending on the consistency with which these outcomes were associated with reinforced or non-reinforced trials in the pattern and on how many trials back these outcomes occurred. The second hypothesis accounted for the relative frequency of errors on trials at various locations in the sequences, and predicted most of the changes in error frequency observed in experiments in which "inter-trial stimuli" were added to the sequences.

Journal Article↗
PubMedDate not supplied

Selection of an instrument to measure the physical activity of elderly people in rural areas.

Physical activity is an important factor in the care of adults 65 years and older who have had a cardiac event. Valid and reliable measurement is critical to nursing assessment, screening, and ongoing evaluation. This article describes the process used to evaluate the quality, including the reliability and validity, of a physical activity instrument for use in a rural population. The sample consisted of 32 adults who had participated in one of four rural cardiac rehabilitation programs. The Physical Activity Scale for the Elderly (PASE), which was selected for this study, was found to be reliable. Experts judged the content to be appropriate and valid for older adults living in rural areas. Perceived health was positively related to physical activity (r = 0.31, p = .08). The PASE was found to be marginally valid. Although further investigation of the instrument's construct validity is warranted, the use of such physical activity surveys has potential clinical relevance for the rehabilitation of older adults from diverse geographic and cultural backgrounds.

Activities of Daily Living↗
PubMedDate not supplied

Prospective evaluation of twice-daily cefotaxime in the treatment of hospitalized patients with severe infections.

Cefotaxime 2 g every 12 h was administered to adults with severe nosocomial pneumonia in a prospective noncomparative study. The results confirmed that this regimen is adequate and appropriate therapy for nosocomial pneumonia, with the combination of cefotaxime and an aminoglycoside reserved for cases where multiresistant, Gram-negative bacterial infections are strongly suspected.

Adult↗
PubMedDate not supplied

Primary and secondary prevention strategies among older postmenopausal women.

Women may choose to initiate, reinitiate, or discontinue hormone replacement therapy (HRT) at any time beyond the perimenopausal period. HRT, exercise, and nutrition are reviewed in terms of their potential benefits as primary and secondary preventive therapies against coronary heart disease, osteoporosis, breast and genital cancers, and the maintenance of cognitive function among older postmenopausal women. Lifestyle alternatives involving nutrition and exercise that offer many of the same benefits as HRT are discussed. Since both pharmacologic and lifestyle interventions offer significant benefit for primary and secondary prevention of disease and disability, each should be offered to women for consideration as they enter the perimenopausal period. Additionally, each can be recommended for initiation even at much older ages and subsequent to adverse health occurrences, such as the experience of breast or genital cancer or a cardiac event. Each should be sustained over the long term. The decision whether to discontinue these interventions among the most elderly will be influenced by other quality of life considerations.

Aged↗