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Biomedical subjects

C Griscelli

Publications and source records attributed to C Griscelli.

At least 325 records · Page 18Linked to original sources
PubMed1975

[Ultrastructure of the blood platelets in Wiskott-Aldrich syndrome].

The platelets of 3 undoubted cases of Wiskott-Aldrich syndrome and of 1 suspected case have been investigated from the ultrastructural point of view. The platelet defects were striking by their small size, variable and distorted shape with numerous microvillosities, degranulated cytoplasm (scarce granules or lysosomes, rare mitochondria) and the distension of the canalicular system. The specificity of the ultrastructural platelet defects was discussed in comparison with other hereditary platelet diseases. An attempt was made to find out the meaning of the platelet alterations in this immunologic deficiency.

Blood Platelets↗
PubMed1975

Peyer's patches, gut IgA plasma cells and thymic function: study in nude mice bearing thymic grafts.

Nude mice have poorly developed Peyer's patches with very small or no germinal centers and little lymphoid cell proliferation, and a marked decrease in the number of gut-IgA plasma cells. Thymus grafts, which restore the T lymphocyte population of their lymphoid organs to nearly normal levels, lead to a considerable development of the Peyer's patches and of their germinal centers, assocaited with a considerable increase in gut IgA plasma cells, and in the serum IgA level. These findings are consistent with the postulated relationship between the Peyer's patches germinal center cells and the gut IgA plasma cells, and might help to explain the association of thymic defects, low serum IgA, and lack of intestinal IgA plasma cells observed in some immunodeficiency syndromes of man. Nude mice also have marked decrease in the number of lymphocytes present within the intestinal epithelium. These intraepithelial lymphocytes lymphocytes, which have been shown to be of T nature, are restored to normal numbers after thymus grafting.

Animals↗
PubMed1974

[Inflammatory rheumatism in immunologic deficiencies].

The authors give a general review of rheumatic manifestations associated with immunodeficiency in children with reference to 7 personal observations. The review demonstrates the high frequency of this association, the variable clinical picture in one, a few, or many joints, the prolonged, relatively mild evolution that is never deforming or ankylosing, the existence of frequent auto-immune and rheumatic manifestations in families, and the usual but variable effectiveness of gammaglobulins. The possibility of immunodeficiency should be considered in cases of mono-, oligo-, and polyarthritis. The results of humoral and cellular immunological studies demonstrated a low level of immunoglobulins, the presence of nonfunctional B cells, and the presence of T cells that were probably qualitatively modified. A physiopathological interpretation is suggested.

Adolescent↗