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Biomedical subjects

C Griscelli

Publications and source records attributed to C Griscelli.

At least 307 records · Page 17Linked to original sources
PubMed1978

[Painful disseminated fibromatosis (systemic hyalinosis): a new hereditary collagen dysplasia].

A case of systemic hyalinosis is reported and the main features of this unusual affection are quoted. The systemic hyalinosis is a syndrome exhibiting the following symptoms : a distressing arthogryposis syndrome, a diffusely stiff skin, some subcutaneous and submucosal fibrotic nodular lymps, repeated suppurative original infections and a facial dysmorphy. Biopsies of nodules show an active proliferation of the connective tissue associated with some peculiar hyalin changes of the collagen fibres. Most cases including the present one die in the first years. The pathogenesis is presently unknown. The systemic hyalinosis seems to be an autosomic recessive heritable disorder and is reasonably settled in the large group of the hereditary diseases of the connective tissue.

Arthrogryposis↗
PubMed1977

Electrophoretic mobility of lymphocyte populations in juvenile rheumatoid arthritis.

Peripheral blood lymphocytes from 16 patients with juvenile rheumatoid arthritis and 27 age-matched healthy controls have been studied, using several lymphocyte markers: electrophoretic mobility (EM), E-rosettes, immunofluorescence, and refringency. Eight patients (mean age, 6 years) were selected with a typical EM pattern--that is, a decrease in the mean EM of T cells and increase in B versus T-cell ratio. The other group of patients (mean age, 11 years) showed no significant difference when compared with their age-matched controls, with the exception of the positive refringence test. These findings suggest an impairment in the maturation of the immune system in childhood, which in turn may be responsible for the increased susceptibility to disease.

Adolescent↗
PubMed1976

[The use of new immunoglobulin preparation, enriched in IgA and IgM (IgGAM)].

The clinical results obtained with fraction IgGAM are reported. Different types of antibody deficiency syndromes have successfully been treated : 8 cases of Bruton-type agammaglobulinemia. In one of these case a tenacious Pseudomonas infection cleared off during the treatment. Two cases of non sex-linked familial agammaglobulinemia. Three cases of isolated IgM deficiency. Five cases of isolated IgA deficiency. Five cases with Soothill type IgA deficiency associated with high IgE levels. Five cases of septicemia of the new-born. Three cases with acquired agammaglobulinemia and in the premature infant (5 cases). No side-effects nor appearance of anti-IgA antibodies have been observed.

Adult↗
PubMed1976

Immediate postnatal decontamination as a means of obtaining axenic animals and human infants.

A technique not involving surgery is described for obtaining axenic (germ-free) newborn animals and human infants by decontamination immediately after birth. Three steps are involved: cleansing ther perineal region of the mother with an iodinated bactericidal solution, washing the newborn with the same solution, and after the newborn has been placed in a sterile isolater, administering a single oral dose of an antibiotic mixture previously determined to be active against the fecal and vaginal flora of the mother. All of the newborn obtained by means of this technique, including 13 piglets, 2 lambs, and 4 human infants, were found to be axenic throughout their stay in the isolators. Four piglets obtained by the same technique, but without adminstration of antibiotic mixture, were found not to be anenic. This technique, as compared with methods of surgical delivery of axenic young, embodies a number of advantages. It is harmless to the mother and to the newborn, it is relatively inexpensive, and it obviates the risk of prematurity involved in elective surgical delivery before term.

Administration, Oral↗
PubMed1976

[Elimination from the digestive tract of a "gnotoxenic" child of a "Lactobacillus casei" strain, isolated from a commercial preparation: antagonistic effect of an "Escherichia coli" strain of human origin, demonstrated in "gnotoxenic" mice (author's transl)].

A strain of Lactobacillus casei from a pharmaceutical preparation became established in the digestive tract of an axenic child. It was eliminated by the first bacteria occurring after inoculation of the child's digestive tract with a human flora, before the child was taken out of the isolator. Using "gnotoxenic" mice, we found that the elimination of L. casei was due to a bactericidal effect of the Escherichia coli of human origin, within the digestive tract.

Actinomycetaceae↗