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Biomedical subjects

C Gibson

Publications and source records attributed to C Gibson.

At least 73 records · Page 4Linked to original sources
PubMed1981

The migratory properties of indium-111 oxine labelled lymphocytes in patients with chronic lymphocytic leukaemia.

These studies describe the application of a new method for following the migration of autologous lymphocytes in normal subjects and patients with chronic lymphocytic leukaemia (CLL). There is evidence that Indium 111 oxine is a reliable radioactive cell label for in vivo studies of lymphocyte traffic in man. In normal subjects, where 60-70% of the lymphocytes labelled are T cells, the results are different from those of previous workers. The lymphocytes leave the blood initially but later return to it. It is believed that this is due to the reappearance of cells which at first entered the spleen. It is suggested that the difference between these data and those of Hersey (1971) is due to the failure of lymphocytes in the latter studies to return to the blood after primary migration. In CLL no such reappearance in the blood is seen and the lymphocytes do not leave the spleen in significant numbers over 48 h. This suggests that CLL B cells either do not recirculate through spleen or that their transit time is greater than 48 h. Bone marrow localization in CLL patients is greater than in the normal subjects, suggesting that either a larger proportion of the neoplastic B lymphocytes enter this compartment or their transit time through it is longer than the transit time of a normal T cell predominant population. Localization in normal-sized lymph nodes in patients with CLL is less than that in the lymph nodes of normal subjects. This may possibly be explained by the greater propensity of T lymphocytes to enter lymph nodes than B lymphocytes, or by the altered migratory properties of CLL B lymphocytes as compared with normal B cells.

Adult↗
PubMed1981

Standards of practice: nutritional quality assurance in acute-care hospitals.

Although the standards were written originally for use in acute-care hospitals, they are guidelines that can be tailored to any health care institution's nutritional needs. The practice standards could also be used to illustrate those areas in nutritional assessment, care, and documentation that need additional improvement. As a result of the research and development of the practice standards, more concise and informative medical record entries are possible, thereby furnishing nutritional care providers with an invaluable tool.

Colorado↗
PubMed1981

A method for following human lymphocyte traffic using indium-111 oxine labelling.

A method is described whereby large numbers of human lymphocytes are separated from peripheral blood and labelled in vitro with indium-111 oxine. Following autologous reinjection, the distribution within the body is followed by means of serial blood samples, surface-probe counting and gamma camera imaging. The distribution of radioactivity following reinjection of heat-damaged labelled lymphocytes and free indium-111 oxine is different from that of 'normal' lymphocytes. The results suggest that the separation and labelling procedure does not cause significant physical damage to the lymphocytes The importance of restricting the specific lymphocyte activity to 20-40 microCi per 10(8) cells in order to minimize radiation damage to the lymphocytes is emphasized. Good resolution of lymphoid structures is obtained using gamma camera imaging and the changes recorded in organ distribution correlate well with data from animal models of lymphocyte migration. Thus, indium-111 oxine labelling of human lymphocytes provides a non-invasive method whereby the migratory properties of human lymphocytes can be followed.

Cell Movement↗
PubMed1981

Human lymphocyte traffic assessed by indium-111 oxine labelling: clinical observations.

Clinical studies using indium-111 oxine labelling of human peripheral blood lymphocytes are presented. Data from animal models of lymphocyte migration are compared with results found in healthy subjects and patients with malignant neoplasms. The physiological significance of bone marrow and liver localization on gamma camera imaging is discussed and the importance of considering the surface marker characteristics of the lymphocytes under study, when interpreting results, is emphasized. The possibility that the redistribution of lymphocytes within the body is a cause of the peripheral blood lymphopenia in patients with Hodgkin's disease and other malignancies is suggested, and the usefulness of indium-111 oxine labelling in clarifying this problem is proposed.

Cell Movement↗
PubMed1980

A digitally linearized thermistor thermometer referenced to IPTS-68.

We describe a digitally linearized thermistor thermometer that is accurate to +/- 0.01 degrees C from 0 to 60 degrees C at a wattage of 50 microW and a sampling time of 1 s. It is traceable to the International Practical Temperature Scale of 1968 (IPTS-68). Analog and digital outputs are provided, the latter as ASCII RS-232C. The thermistor is a 10-cm long immersible probe, 1.5 mm in diameter. Only 0.5 cm of the probe need be immersed, with proper heat sinking of at least 1 cm of the remaining 9.5 cm, for accurate readings. Error from self-heating of the thermistor is less than 5X 10(-3) degrees C at all power settings from 50 to 1 microW.

Autoanalysis↗
PubMed1977

The elusive rise in the American birthrate.

In summary, (i) neither an immediate nor a dramatic increase in fertility will be required during the next few years for young married women to realize their family-size expectations; (ii) annual fertility trends in California do not provide a useful indicator of annual fertility trends at the national level; (iii) recent economic trends appear to merit considerable attention in an assessment of furture fertility prospects. An examination of recent economic conditions suggests that a substantial increase in annual fertility is unlikely to occur immediately. It would be more likely to occur when the current unfavorable economic conditions have been eliminated.

Birth Rate↗