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Biomedical subjects

C E Margo

Publications and source records attributed to C E Margo.

At least 109 records · Page 6Linked to original sources
PubMed1988

Chronic vitritis with macrophagic inclusions. A sequela of treated endophthalmitis due to a coryneform bacterium.

A 75-year-old woman was treated successfully for endophthalmitis due to a coryneform bacterium contracted from a contaminated corneal graft. We were able to study the involved eye histologically when the patient died unexpectedly 5 1/2 weeks after treatment. The vitreous contained a moderate number of macrophages filled with PAS-positive particles. Ultrastructurally, the PAS-positive particles corresponded to degenerating bacterial cell walls. The striking resemblance of the macrophages in this case to macrophages in Whipple's disease is intriguing because Corynebacterium has been the most frequently implicated bacterial genus in the pathogenesis of Whipple's disease.

Aged↗
PubMed1988

Aspergillus panophthalmitis complicating treatment of pterygium.

A 58-year-old woman lost her left eye due to Aspergillus panophthalmitis four months after excision of a pterygium. The patient had received postoperative beta radiation and developed a scleral ulcer in the area of treatment from which no organisms could be cultured on two occasions. Because of the difficulty of diagnosing superficial mycotic infections of the eye, and because the treatment of so-called radiation scleritis may worsen fungal infections, ophthalmologists need to be aware of the potential infectious complications associated with the treatment of pterygia.

Aspergillosis↗
PubMed1988

Windows and blinking: techniques for enhanced ocular computed tomographic imaging.

Computed tomography (CT) has become an important diagnostic modality in the evaluation of ocular and orbital disease. A weakness of CT, however, is its inability to show clearly intraocular lesions that do not contain calcium. These images can be improved by the careful selection of window width and window level and by the use of a technique known as "blinking." The use of these enhancement techniques is illustrated in two cases of leukocoria in children.

Eye↗
PubMed1987

Isolated inferior rectus muscle palsy from a solitary metastasis to the oculomotor nucleus.

A 55-year-old man with squamous cell carcinoma of the esophagus had vertical diplopia secondary to metastasis to the brain stem. The lesion was detected by magnetic resonance scanning but not by computed tomography. Clinically, the disturbance in ocular motility localized to the right inferior rectus muscle. At autopsy, a single metastasis was present in the brain stem, contiguous with the right oculomotor nucleus and involving a small portion of the nucleus. The findings in this case support the concept that, in humans, the oculomotor nucleus is organized into functional subnuclei.

Brain Stem↗
PubMed1987

Large congenital melanocytic nevus. Light and electron microscopic findings.

The family of a 10-month-old black girl with a large periocular congenital melanocytic nevus (CMN) was given markedly differing advice from experienced physicians regarding how the lesion should be managed. The nevus was eventually removed surgically because of concern about the risk of malignant transformation and because of its cosmetic appearance. Histologically, the lesion was a dermal nevus, but extended deeply into subcutaneous tissue and had neuroid features. The ultrastructural characteristics of melanocytes varied according to the depth at which they resided, but cells did not differ basically from melanocytes found in smaller acquired nevi. Given the limited understanding of the biologic basis for malignant transformation, large size remains the most important risk factor in CMN.

Child↗
PubMed1987

Corneal manifestations of scleromyxedema.

Bilateral superficial corneal deposits and scleromyxedema, an uncommon dermatosis caused by the accumulation of acid mucopolysaccharide in the skin often associated with a benign monoclonal gammopathy developed in a 71-year-old man. A biopsy specimen of the cornea showed that the deposits stained strongly positive for IgG and lambda chains. Ultrastructurally, the deposits consisted of amorphous granular material. Scleromyxedema should be considered in the differential diagnosis of noninflammatory superficial keratopathies associated with benign gammopathies.

Aged↗
PubMed1987

Bilateral melanocytic uveal tumors associated with systemic non-ocular malignancy. Malignant melanomas or benign paraneoplastic syndrome?

A 90-year-old woman developed bilateral diffuse melanocytic tumors of the uveal tract nearly 1 year before she died from an occult ovarian carcinoma. Although the syndrome of bilateral diffuse melanocytic tumors of the uvea and systemic carcinoma has been described, the uveal tumors in this patient were different in that they were indistinguishable histologically from mixed cell-type malignant melanoma. Although the relationship between the systemic malignancy and the uveal tumors is unclear, the cytologic features of the uveal tumors in this syndrome are probably more variable than originally thought.

Aged↗
PubMed1987

Extracranial manifestation of invasive pituitary adenoma.

An invasive pituitary adenoma caused nasal obstruction and marked visual loss due to compression of the optic chiasm. Surgical and medical treatment produced dramatic recovery of vision. Although the reason that certain prolactin-secreting adenomas behave in a locally aggressive fashion is unknown, the prognosis for invasive pituitary adenomas, in general, is relatively good.

Adenoma↗
PubMed1987

Corneal pseudocyst following acute hydrops.

A 20-year-woman with bilateral keratoconus developed acute hydrops of her right cornea. The amount of corneal oedema progressively increased over eight weeks while the central cornea thinned. Histologically the cornea contained a stromal pseudocyst that was in continuity with the anterior chamber through breaks in Descemet's membrane. Pseudocyst formation is a rare complication of acute corneal hydrops that can simulate severe corneal ectasia.

Adult↗
PubMed1987

Cavernous sinus syndrome as the initial manifestation of multiple myeloma.

A 76-year-old man developed a cavernous sinus syndrome as the initial manifestation of multiple myeloma. Although clinically the patient had stage IA disease, which is typically associated with a favorable response to therapy, his disease was rapidly fatal. This case emphasizes a weakness of the traditional staging system because it does not take into account certain clinical and histopathologic aspects of myeloma relevant to extramedullary plasmacytomas. Since disorders of ocular motility are more likely to be associated with extramedullary myeloma than myeloma confined to the marrow, clinicians need to be aware of the limitations in the clinical staging system and the potential problems associated with anaplastic plasmacytomas.

Aged↗
PubMed1987

Hereditary cataracts in the John Rapp inbred strain of Dahl salt-sensitive rat.

Cataracts were apparently fixed in the genome of a highly inbred strain of Dahl salt-sensitive (S/JR) rat during the course of the selection for hypertension. Cataracts were present in S/JR rats inbred for more than 40 generations, but were not present in any of the salt-resistant rats (R/JR) inbred and observed during the same time. Light and electron microscopic evaluation of 11 pairs of S/JR rat lenses revealed a large posterior capsular defect and marked degenerative changes in lens fibers in each case. While the reason for the posterior capsular break is unclear, the cataract is probably a manifestation of an abnormal recessive gene or a recent autosomal dominant mutation.

Animals↗
PubMed1987

Acanthamoeba keratitis.

A 41-year-old woman underwent a corneal transplant in her right eye because of a nonhealing ulcer. The graft failed within weeks of surgery and was eventually removed. Both the primary host cornea and the failed graft contained numerous Acanthamoeba cysts and trophozoites. Awareness of the causes of infectious keratitis should increase the likelihood of establishing the correct diagnosis.

Adult↗
PubMed1986

Selling surgery.

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