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Biomedical subjects

C E Margo

Publications and source records attributed to C E Margo.

At least 127 records · Page 7Linked to original sources
PubMed1986

Therapeutic ultrasound. Light and electron microscopic findings in an eye treated for glaucoma.

Focused high-intensity (FHI) ultrasound has recently been used to treat advanced glaucoma. This report describes the pathologic findings in the eye of a 30-year-old woman treated with FHI ultrasound for glaucoma. Major findings consisted of highly localized destruction of the pigmented and nonpigmented ciliary epithelium, profound atrophy of the ciliary muscle, and loss of scleral collagen. While the mechanism by which FHI ultrasound reduces intraocular pressure is not completely understood, the histologic effects of ultrasonic radiation are localized to the site of treatment.

Adolescent↗
PubMed1986

Psammomatoid ossifying fibroma.

Fibro-osseous lesions represent a variety of bone proliferations each characterized by different morphologic patterns of osteoid production. Psammomatoid ossifying fibroma (POF) is characterized histologically by numerous small round ossicles resembling psammoma bodies and is a locally invasive lesion of facial and cranial bones. Two cases of POF arising in the ethmoid sinus and involving the orbit are presented to emphasize the importance of complete surgical removal of involved bones. Histologically, portions of POF may demonstrate other patterns of osteoid production, which resemble fibrous dysplasia and Paget's disease of bone. The variation in radiodensity in POF on computed tomography is a function of the density of psammomatoid ossicles and of the coexistence of other "minor" forms of bone proliferation.

Child↗
PubMed1986

Gamma-enolase activity in choroidal melanoma.

Gamma-enolase is a glycolytic enzyme that is found in high concentration in neural and neuroendocrine tissues. The enzyme has been considered clinically useful as a tumor marker in the evaluation of small-cell undifferentiated malignancies. A preliminary report suggested that gamma-enolase activity may be used in the assessment of the malignant potential of choroidal melanoma. To test this hypothesis and document the distribution of gamma-enolase in the eye, we studied the immunohistochemical activity of gamma-enolase in six eyes from persons with choroidal melanoma. Although no correlation could be found with gamma-enolase activity and tumor size or tumor cell type, the distribution of gamma-enolase in normal retina and optic nerve was described. The areas of greatest immunohistochemical reactivity were the perikaryon of ganglion cells, inner and outer plexiform layers, and the nerve axons of the nerve fiber layer and optic nerve. Gamma-enolase may be a potentially useful marker of retinal and optic nerve glycolysis, and of neuronal function.

Choroid↗
PubMed1986

Dermal myiasis of the eyelid.

A case report describes the clinical findings of dermal myiasis of the upper eyelid in a 6-year-old girl from South America. Dermal myiasis due to Dermatobia hominis can simulate a common furuncle and is known to occur in world travelers.

Child↗
PubMed1986

Eosinophils in corneas removed by penetrating keratoplasty.

One hundred consecutively submitted corneas removed by penetrating keratoplasty were studied histologically to determine the frequency in which eosinophils are found. In 20 corneas eosinophils occurred in densities ranging from 0.2 to more than 50 per high power field (HPF), and accounted for 1.5% to 100% of the total leucocytes counted. More than half of the corneal specimens containing eosinophils, including six of seven corneas having the highest eosinophil concentrations, were failed grafts. Because the concentration of eosinophils was in many cases beyond that attributable to non-specific vascular permeability, the existence of eosinophil chemotaxic substances in the cornea is postulated.

Cornea↗
PubMed1986

Mucoepidermoid carcinoma of the conjunctiva: report of a case in a 36-year-old with paranasal sinus invasion.

Mucoepidermoid carcinoma is a rare, highly invasive tumor of the conjunctiva that occurs in elderly persons. Although clinically indistinguishable from squamous cell carcinoma, mucoepidermoid carcinoma is more likely to recur following excision and to invade the eye. The following case report describes a 36-year-old man with mucoepidermoid carcinoma of the right caruncle that invaded orbit, paranasal sinuses, and nasal cavity. The patient is the youngest person known to have had this tumor, and represents the first reported case in which mucoepidermoid carcinoma of the conjunctiva has extended beyond the orbit. This case emphasizes the importance of prompt and adequate primary treatment.

Adult↗
PubMed1985

Psammomatoid (juvenile) ossifying fibroma of the orbit.

The clinical and pathologic features in 21 cases of a distinctive solitary fibro-osseous lesion affecting the orbit distinguished histologically by the dominance of numerous small round "psammoma-like" ossicles embedded in a cellular benign spindle cell stroma were studied. The patients were predominantly young, and 19 of the lesions were centered on the orbital plate of the frontal bone or ethmoid. A clinical course of slowly progressive symptoms over several years was typical but not uniform. The most common clinical diagnosis was fibrous dysplasia and mucocele. At least nine patients underwent two or more surgical operations; one patient had six recurrences over a 15-year period. There were no known deaths from the tumor, but its potentially massive size can result in considerable morbidity and cosmetic deformity. Although previously referred to as active juvenile ossifying fibroma, the term psammomatoid ossifying fibroma for this lesion is more descriptive and has historical precedence.

Adolescent↗
PubMed1985

Ectopic lacrimal gland tissue of the orbit and sclerosing dacryoadenitis.

A 28-year-old man with unilateral proptosis was found to have sclerosing dacryoadenitis and ectopic lacrimal gland tissue of the orbit. The unusual combination simulated invasive adenocarcinoma of the lacrimal gland both clinically and histopathologically. Based on clinical and experimental observations, we propose that the acinar gland atrophy and fibrous replacement of the lacrimal gland and of the heterotopic tissue was the result of a primary developmental abnormality associated with obstruction to normal gland outflow. Physician awareness that ectopic lacrimal gland tissue in the orbit can be affected by sclerosing dacryoadenitis is probably the most critical factor in establishing the correct diagnosis.

Adult↗
PubMed1985

Hodgkin's disease and granulomatous uveitis.

A poorly understood association between Hodgkin's disease and noncaseating granulomas has been well documented in all stages of the lymphoma. Characteristically, the granulomas are found within liver, spleen, lymph nodes, and bone marrow. The following case report describes a 21-year-old woman with Stage 1-A nodular sclerosis Hodgkin's disease who had both multiple noncaseating granulomas in her spleen and an abdominal lymph node, as well as bilateral granulomatous uveitis.

Adult↗
PubMed1984

Malignant melanoma of the choroid and ciliary body in black patients.

In a retrospective study of choroidal and ciliary body malignant melanomas in black patients, we found that the death rates due to metastatic melanoma after enucleation were equivalent for 39 blacks and 3,339 whites. When compared with a control group of whites, it was found that blacks were more likely to have secondary glaucoma and inflammation prior to enucleation. Of the histopathologic features analyzed, the presence of necrosis or mixed or epithelioid type cells within the tumor was associated with increased mortality in blacks. The histopathologic features of malignant melanomas in blacks and whites were similar, except that tumor necrosis and heavy pigmentation were found more frequently in tumors of blacks.

Actuarial Analysis↗