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Biomedical subjects

C E Margo

Publications and source records attributed to C E Margo.

At least 91 records · Page 5Linked to original sources
PubMed1991

Retinal pigment epithelial tear after treatment of metastatic carcinoma of the choroid.

A 59-year-old woman developed a tear of the retinal pigment epithelium (RPE) shortly after receiving radiation therapy and chemotherapy for metastatic breast carcinoma to the choroid. If the RPE tear had not been observed during the early stage of its evolution, the subsequent coiled mass of RPE could have been easily mistaken for reactive hyperplasia. The location of the RPE tear relative to the choroidal metastasis and its temporal relationship to tumor involution suggest that the RPE tear and therapy for metastatic carcinoma were causally related. This is the first description of an RPE tear overlying a metastatic tumor.

Adenocarcinoma↗
PubMed1990

Retinochoroidal degeneration associated with progressive iris necrosis.

A 34-year-old man in good general health became bilaterally totally blind by an unusual retinochoroidal degenerative disease 3 years after the initial onset of visual symptoms. The advanced stages of the retinochoroidal disease were associated with bilateral progressive iris necrosis and severe ocular pain. The constellation of findings and course of this disease represent a clinical entity that has not been previously described in the literature.

Adult↗
PubMed1990

Granulomatous uveitis after treatment of a choroidal melanoma with proton-beam irradiation.

Histologic examination of an eye removed 2 years after receiving proton-beam irradiation for a choroidal melanoma revealed residual tumor in the choroid and nonnecrotizing granulomatous inflammation, consistent with the diagnosis of early sympathetic ophthalmia. Sutures that secured four tantulum rings to the sclera did not penetrate the uvea. Sympathetic ophthalmia without evidence of a perforating injury has been described previously after helium ion therapy. The findings in our case further support the hypothesis that there is a risk of developing sympathetic ophthalmia after charged-particle therapy in the absence of a penetrating injury of the uveal tract.

Choroid Neoplasms↗
PubMed1990

Lipid crystals in malignant melanoma of the choroid.

The crystallization of extracellular lipid (other than cholesterol) in histologic preparation is a rarely observed phenomenon. The following case report describes lipid crystals within a necrotic uveal melanoma. Ultrastructural findings suggest that lipids released from necrotic lipidized melanoma cells were the source of the extracellular deposits. No unique lipids were identified from extracts of the tumor using thin layer chromatography. Energy dispersion microanalysis revealed elemental concentrations within the crystals comparable to intracellular organelles.

Aged↗
PubMed1989

Bilateral idiopathic inflammation of the optic nerve sheaths. Light and electron microscopic findings.

Idiopathic perioptic neuritis is a term used to describe noninfectious inflammatory disorders of the optic nerve sheaths, the causes of which are unknown. In the following report, a 68-year-old woman with bilateral visual loss was found to have chronic inflammation with necrobiotic granulomas of her optic nerve sheaths. The patient, who had no systemic condition known to be associated with necrobiotic granuloma, lost vision from infarction of the optic nerve parenchyma and from compression due to thickened meninges. Although there are similarities between the inflammatory reaction in this case to the necrobiotic dermatoses, the pathogenesis of this condition remains obscure.

Aged↗
PubMed1989

Sixth nerve palsies, temporal artery biopsy, and necrotizing vasculitis.

A 79-year-old man with diplopia and weakness was found to have necrotizing vasculitis consistent with polyarteritis nodosa on temporal artery biopsy. Although he had no evidence of visceral involvement from vasculitis, he responded well to corticosteroid therapy. This case illustrates a nosological problem that can occur when dealing with a disease that has diverse clinical manifestations and nonspecific laboratory findings. Moreover, this case demonstrates the value of including a branch artery segment when biopsying the temporal artery.

Abducens Nerve↗