Biomedical subjects
Publications and source records attributed to C Chastel.
A case of ocular infection due to adenovirus type 19 is reported. The patient developed a bilateral keratoconjunctivitis with preauricula nodes and a mild general malaise. The virus was isolated from both eyes; serological tests carried out on the serum of the patient were compatible with the diagnosis.
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Fifteen cases of herpes simplex epithelial keratitis, which failed to heal following IDU therapy, were treated with Ara-A 3% ointment applied fives times daily. Epithelial disease resolved in fourteen cases with Ara-A and mean healing time was 6,6 days. No sign of ocular or adnexal toxicity were noted.
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HLA-antigens of 80 patients with recurrent ocular herpes simplex infection were compared to a control population. HLA-B5 antigen was significantly more common in the first group. Several hypothesis are discussed in order to explain a relationship between recurrent ocular herpes simplex infection and HLA-antigens.
A study was made on the presence of antibodies against lymphocytic choriomeningitis virus in 452 children in the Lyon area who had suffered from either a major pathological condition or a congenital malformation at birth. Of 34 cases of congenital hydrocephalus, only one could be definitely attributed to a maternal infection with the virus, occurring between the 5th and 6th months of pregnancy. Lymphocytic choriomeningitis virus should thus be added to the list of those which are potentially teratogenic for the human species.
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The brain electrographic activity of mouse experimental LCM has been systematically compared with the pathology and the virus growth in brain. There is an excellent correlation between anatomic lesions and brain electrographic activity which begins in slow waves followed with electric discharges attendant upon clinical paroxysms. The different records have been described and a physiopathological interpretation of these electroclinical paroxysms is proposed.
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We have carried out a sero-epidemiological investigation with regard to the "Torch complex" in 702 women aged from 11 to 49 years and living in an urban district of the Finistere or Morbihan. The proportion of protected women was relatively low compared with other regions of France: 50.14% for toxoplasmosis 74.64% for rubella, 23.70% for cytomegalovirus and 39.61% for herpes. Furthermore, no woman had any antibodies for the virus of lymphocytic choriomeningitis, another potentially teratogenic virus. It thus seems advisable to supervise the serology of pregnant women in our region for the whole of the Torch complex. The practical modalities and the choice of serological reactions are discussed.
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