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Biomedical subjects

C Anderson

Publications and source records attributed to C Anderson.

At least 469 records · Page 26Linked to original sources
PubMed1989

Thromboxane synthesis inhibition and renal allograft function.

These data indicate that chronic administration of CGS-12970 to renal allograft recipients maintains renal allograft function. These effects are probably due to selective inhibition of local tissue TXA2 production. These data also suggest that elevations in renal allograft tissue prostacyclin production may be secondary to ischemia since improving renal blood flow and GFR with selective thromboxane synthesis inhibitors leads to normalization of renal prostacyclin synthesis. The possible utility of using CGS-12970 as an adjunct therapy in human renal allotransplantation should be strongly considered.

6-Ketoprostaglandin F1 alpha↗
PubMed1989

Vancomycin.

Explore the source record for details and available documents.

Humans↗
PubMed1988

Possible case of hyperparathyroidism in a Roman period skeleton from the Dakhleh Oasis, Egypt, diagnosed using bone histomorphometry.

A histomorphometric study of thin femoral head sections of a skeletal sample from the Dakhleh Oasis, Egypt, dated from circa 36 B.C. to 400 A.D., identified an adult female (Dk31-A1) in her mid-50s with a high percentage resorption surface with tunneling resorption as is typically found in hyperparathyroidism. Five static histomorphometric bone parameters were measured with the following results for this individual: 1) mean wall thickness, 41.94 micron, 2) trabecular bone volume, 18.54%, 3) surface volume, 4,070 mm2/cm3, 4) mean trabecular diameter, 132 microns, and 5) total resorption surface, 12.31%. The overall histomorphometric features and differential diagnosis support the diagnosis of hyperparathyroidism. We conclude that histomorphometry of dried bone, particularly in this case where preservation is ideal, is a valuable investigative technique for paleopathology.

Bone and Bones↗
PubMed1988

Immunohistochemical study of 5-HT-containing neurons in the teleost intestine: relationship to the presence of enterochromaffin cells.

The formaldehyde-induced fluorescence technique had shown 5-hydroxytryptamine-containing enteric neurons in the intestine of the teleost Platycephalus bassensis, but did not reveal such neurons in the intestine of Tetractenos glaber or Anguilla australis. Re-examination of these animals with 5-hydroxytryptamine immunohistochemistry showed immunoreactive enteric neurons in the intestine of all three teleost species. The 5-hydroxytryptamine-containing enteric neurons showed essentially the same morphology in all species examined: the somata were situated in the myenteric plexus, extending down into the circular muscle layer, but none were found in the submucosa; processes were found in the myenteric plexus, the circular muscle layer and the lamina propria. It was concluded that the neurons may innervate the muscle layers or the mucosal epithelium, but were unlikely to be interneurons. In a range of teleosts, enterochromaffin cells were found in the intestine of only those species in which the formaldehyde technique did not visualize neuronal 5-hydroxytryptamine. Available evidence suggests that, in vertebrates, 5-HT-containing enterochromaffin cells are lacking only where there is an innervation of the gut mucosa by nerve fibres containing high concentrations of 5-HT.

Animals↗
PubMed1988

Bone histomorphometry, bone mass, and related parameters in alcoholic males.

Bone mass and related metabolic variables were studied in 50 males known to be, or to have been, regular alcohol abusers. Subjects were divided into those who were still drinking and those who had abstained for at least 3 months, and the former further subdivided into moderate and heavy drinkers. Twenty-five had at least two atraumatic spinal crush fractures. In 25 cases, bone histomorphometry was carried out. Lumbar bone mineral density and iliac crest bone volume were significantly lower in spinal crush fracture cases. Parathyroid hormone, testosterone, and urinary cortisol measurements showed no difference between groups. Alkaline phosphatase and 24-hour urine hydroxyproline were higher in osteoporotics than in nonosteoporotics. On bone histomorphometry, there were essentially no differences between those with and those without fractures in terms of bone formation and resorption parameters. Drinkers showed lower osteoid seam width and fraction of osteoid covered by osteoblasts, as well as fewer osteoblasts per 10 cm of bone surface than abstainers. Mineralization lag time was prolonged, and mineralization rate per day was lower in the drinkers. Osteon formation time was prolonged in the drinkers. On the resorption side, only the osteon resorption time was significantly different in the drinkers, being prolonged. The heavy drinkers, but not the moderate drinkers, had a significantly reduced surface extent of lacunae. We conclude that alcohol consumption has clear detrimental effects on bone formation with less pronounced suppressive effects on bone resorption. In no biochemical or hormonal measurement, however, with the exception of hydroxyproline excretion and plasma alkaline phosphatase, could those who had osteoporosis be distinguished from those who did not.

Alcoholism↗
PubMed1988

Modes of word recognition in the left and right cerebral hemispheres.

Four experiments are reported examining the effects of word length on recognition performance in the left and right visual hemifields (LVF, RVF). In Experiments 1 and 2 length affected lexical decision latencies to words presented in the LVF but not to words presented in the RVF. This result was found for both concrete and abstract nouns. Changing from a normal horizontal format to the use of unconventionally "stepped" words, however, produced length effects for words in both visual hemifields (Experiment 3). The Length x VHF interaction was found once again in Experiment 4 where subjects classified words as either concrete or abstract. A model proposing two modes of visual processing of letter strings is presented to account for these findings. Mode A operates independent of string length and is seen only in left hemisphere analysis of familiar words. Mode B is length dependent: it is the only mode possessed by the right hemisphere but is displayed by the left hemisphere to nonwords and to words in abnormal formats.

Cerebral Cortex↗
PubMed1988

Cluster formation in PHA-stimulated mononuclear cells from peripheral blood: effects of colcemid and taxol.

Mononuclear cells from peripheral blood were incubated with phytohemagglutinin (PHA) for 24-72 hours. The cells formed dense cell clusters with firm cell-to-cell attachment and signs of cell communication, proliferation and differentiation. At the end of a 72-hour period of incubation, the test preparations were treated for 90 minutes with the classical microtubule antagonist Colcemid and the new microtubule antagonist taxol. Taxol produced approximately twice as many mitoses as Colcemid. Chromosomes in taxol-blocked mitoses appeared to be more contracted than chromosomes in Colcemid-blocked mitoses. It is suggested that one beneficial side effect of Colcemid preparation of chromosomes is stretching due to microtubule disassembly.

Alkaloids↗
PubMed1988

Changes in bone mineralization pattern: a response to local stimulus in maxilla and mandible of dogs.

A pilot study was carried out in order to verify the pattern of changes in mineralization of bone in the maxillas and mandibles of dogs which had a tooth extraction or luxation. Bone mineral content was determined using computerized microdensitometry. Significant changes in patterns of mineralization were found for alveolar bone, cortical bone and trabecular bone at the sites adjacent to the area of operation. These findings suggest that the three envelopes of jaw bones of the dogs are influenced by Regional activation phenomenon (RAP). These results have important implications for the design of clinical studies of periodontium. A more detailed study should elucidate the cellular mechanisms by which these changes occur.

Animals↗