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Biomedical subjects

B Werner

Publications and source records attributed to B Werner.

At least 109 records · Page 6Linked to original sources
PubMed1980

Protective effects of cholestyramine on liver cirrhosis induced by carbon tetrachloride in the rat.

The influence of cholestyramine and chenodeoxycholic acid on the induction of liver cirrhosis by carbon tetrachloride was investigated in the Wistar rat. The addition of 1.3% cholestyramine to the diet of the experimental animals inhibited to a large extent the induction of cirrhosis. While all the animals subjected to carbon tetrachloride exposure plus basal diet and those to carbon tetrachloride intoxication plus chenodeoxycholic acid diet developed cirrhosis, the morphological manifestation of cirrhosis occurred in the livers of only two out of 18 rats under carbon tetrachloride treatment plus cholestyramine diet. The administration of cholestryamine induces reactions which correspond to the physiological protective mechanisms of the liver. These are the bile acid binding, bacteriostatic, and microsomal enzymatic stimulating properties of cholestyramine.

Animals↗
PubMed1980

Endogenous carbon monoxide production after bicycle exercise in healthy subjects and in patients with hereditary spherocytosis.

The occurrence of haemolysis after bicycle exercise was studied by determination of, inter alia, the endogenous carbon monoxide production (VCO) before and after 20 min of exercise at a load of about 70% of predicted maximal oxygen uptake. Eight healthy subjects and six patients with hereditary spherocytosis were studied. VCO was 14.4 and 10.5 mumol CO x mmol per total body haeme per day before and after exercise, respectively, in healthy subjects, and 32.6 and 25.4 mumol CO x mmol per total body haeme per day in the patients. The differences were not statistically signficant. No significant changes occurred in serum total bilirubin, lactate dehydrogenase, haptoglobin or serum iron/total iron binding capacity. In conclusion, no increase in the destruction rate of red cells was observed after this type of exercise, neither in healthy subjects nor in patients with hereditary spherocytosis. In addition, a decrease in COHb of about 20% during exercise was observed in both groups. This could be explained by a redistribution of CO from haemoglobin to myoglobin in association with changes in intracellular oxygen tension in working muscles.

Adult↗
PubMed1980

32P-pyrophosphate in the treatment of persistent metastatic bone pain.

Eight patients with persistent pain due to disseminated bone metastases from mammary carcinoma were given about 370 MBq (10 mCi) of 32P-pyrophosphate on 10 occasions. All but one of the patients experienced alleviation of pain lasting 1 to 4 months. The side effects, which derived mainly from haematopoetic tissue, prevent the routine use of this compound.

Blood Cell Count↗
PubMed1980

[Effect of cholestyramine and chenodesoxycholic acid on liver cirrhosis. An experimental study in rats].

The influence of cholestyramine and chenodeoxycholic acid on the induction of cirrhosis of the liver of the male Wistar strain rats was studied. The simultaneous dietary exposure of 1 g cholestyramine in 100 g diet prevented the development of cirrhosis induced by carbon tetrachloride. Whereas all the animals in the control group (CCl4-Exposure plus normal diet) developed cirrhosis, histologic examination showed cirrhosis in only 2 of 9 rats fed with diet containing cholestyramine. On the contrary, the exposure to chenodeoxycholic acid at a concentration of 1 g in 300 g diet potentiated the induction of cirrhosis. The experimental results support the clinical findings in which the administration of cholestyramine caused an improvement of liver function tests by cirrhosis.

Animals↗
PubMed1979

Hepatitis A and Indian childhood cirrhosis.

Antibody to hepatitis A virus (anti-HAV) was found in 50% of patients with Indian childhood cirrhosis; this was not significantly different from the prevalence of anti-HAV in age- and sex-matched controls.

Antibodies, Viral↗
PubMed1978

[Postgastrectomy syndromes. Development of the aspects in past and present (author's transl)].

After gastric operations about 20 to 30% of all patients complain of an abundance of postoperative gastrointestinal and vasomotor complaints. Research into these "postgastrectomy syndromes" is carried out periodically. In the beginning of this century concepts as precipitated evacuation, dumping stomach, too narrow or too wide anastomosis predominate. In the thirties the subdivision into a so-called early and late dumping syndrome follows. The description and treatment of the afferent loop syndrome in the middle of this century suggest the introduction of functional factors into the explanation of the postgastrectomy syndromes. Next comes the recognition of the pathophysiological significance of the regurgitated duodenal contents into the operated stomach. The endoscopic biopsy gives a broad morphological basis. The postoperative alcaline reflux gastritis temporarily ends the development.

Bile↗
PubMed1978

Inter- and intra-individual variation of carbon monoxide production in young healthy males.

Duplicate studies of endogenous CO production (Vco) were performed in three groups of young healthy males. In group A (eleven subjects) Vco studies were performed with an interval of approximately 1 week. In group B (ten subjects) duplicate studies were done on the same day and in group C (ten subjects) duplicate studies were also done on the same day but with the subjects strictly resting between determinations. The error of the single determination estimated from duplicate measurements (formula: see text) was +/-4.3 mumol/mmol TBH.day (TBH = total body haem) in group A and +/-3.7 and +/-1.0 in group B and C, respectively. Thus the intra-individual variation in Vco was considerably diminished when the duplicate determinations were performed with the subjects strictly resting between determinations. A possible explanation for this might be less variation in blood flow or metabolic processes in tissues engaged in haem breakdown in the resting group compared with the other groups.

Adult↗
PubMed1978

[Duodenal cancer. A clinical-pathological study].

Seven primary carcinomas of the duodenum were observed from 1973 to 1976 at the University Hospital Hamburg; four in females and three in males with an age between 32 and 69 years of age. The interval between the first symptoms (epigastric pain, jaundice, pruritus, diarrhea, and loss of weight) and surgical therapy (duodeno-pancreatectomy) averaged four months. All carcinomas were resected radically from the macroscopic (intraoperative) aspect as well as from the histological findings. Local tumour recurrences which proved fatal occurred in five patients within nine to twenty-one months. One patient died of peritonitis and another of pancreatitis. The diagnostic mode has been changed since the introduction of endoscopy and retrograde cholangio-pancreaticography (ERCP). The consistent inclusion of the duodenum in routine gastroscopy leads to the hope that more carcinomas of the duodenum can be detected early.

Adult↗
PubMed1978

[Radiologically detectable modifications in the cartilaginous parts of the first pair of ribs in connection with age, sex and the cartilaginous part of the other ribs (author's transl)].

2154 thorax radiograms of 1099 male and 1055 female patients with transformations of the costal cartilage were analysed and statistically evaluated in dependence on age. The calcification of the cartilage parts of the first rib was observed on both sides in the same way and concerning the frequency there were no sex conditioned differences. In the age group between 35 and 45 years more than 95% calcifications have been demonstrated. Men show more frequently advanced stages and types of calcification than women. In complete or heavy calcified cartilage zones disconnections in form of splitted parts without calcium have been observed. The lower cartilage skirt is regarded as the localization of the beginning of calcification. The other costal cartilages will be calcified later and less rapidly than the first costal cartilage. Significant differences of type and localization of the calcification were found between men and women. Physiological processes of ageing and mechanical stress as the prevailing calcification-causing factors are discussed.

Adolescent↗
PubMed1977

Experimental carcinogenesis in the resected colon of the rat.

Until now, carcinoma of the large intestine resected previously for benign disease has not been published. However an increasing number of patients resected for Crohn's disease, diverticulitis or trauma may reach nowadays a high lifespan. On the other hand, it is known that the gastroenteral anastomosis is predisposed to cancer development. In this study, the question of whether the large intestine following colotomy or ileotransversostomy is sensitive to carcinogenesis is examined. Male Wistar rats, subjected to colotomy or resection and ileotransversostomy, were treated weekly by subcutaneous injection of 1,2-dimethylhydrazine (12 mg/kg body weight) for seven weeks. The animals were killed 54 weeks after the first injection. At autopsy, 21 out of 29 operated rats had developed adenocarcinomas of the remaining colon. Intact control animals had the same incidence of malignant degeneration of the large bowel. When the anastomosis is chronically irritated by inflammation or by formation of a diverticulum, development, of carcinoma near the stoma was observed. This was the case in three rats of 28 animals. The results demonstrate that the resected colon of the rat is not more sensitive to experimental carcinogenesis than the intact one.

Adenocarcinoma↗
PubMed1977

[Cholecystectomy and experimental coloncarcinoma (author's transl)].

The influence of cholecystectomy on the development of carcinoma of the colon is investigated. The experimental results show a significant high rate of carcinoma of the colon induced by subcutaneous injection of 1,2-Dimethylhydrazin (DMH) in the mouse after cholecystectomy. After 10 weekly injections of 15 mg/kg DMH 70% of the animals with cholecystectomy developed carcinoma. Only 16% of the mice with similar treatment but without cholecystectomy had carcinoma. The cocarcinogenic effect of cholecystectomy is assumed to be due to the increased production of secondary bile salts by the colonic bacteria and the lacking of the resorptive function of the gall bladder for some carcinogenic substances passing through the liver. The background of this experimental studies is the clinical findings that 10% of patients with carcinoma of the large bowels had a cholecystectomy previously.

Adenocarcinoma↗