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Biomedical subjects

B Werner

Publications and source records attributed to B Werner.

At least 127 records · Page 7Linked to original sources
PubMed1977

[The diagnosis of traumatic haemobilia and bilhaemia (author's transl)].

A case of bile passage into the portal vein (bilhaemia) and two cases of haemobilia are reported. The former is a hitherto undescribed complication of liver injury, in the reported case first noted two weeks after trauma. Serum-bilirubin concentration was 560 mg/l (958 mumol/l). Bilhaemia or haemobilia may occur when a fistula has been formed between the bile duct system and the circulatory system, depending on pressure differences between the two. The diagnosis and exact localisation of bilhaemia or haemobilia can be made by endoscopic retrograde cholangiography, a useful complementary test to selective angiography.

Adolescent↗
PubMed1977

Cholecystectomy and carcinoma of the colon. An experimental study.

The influence of cholecystectomy on the development of carcinoma of the colon is investigated. The experimental results show a significantly increased rate of carcinoma of the colon induced by subcutaneous injection of 1,2-Dimethylhydrazin (DMH) in the mouse after cholecystectomy. After 10 weekly injections of 15 mg/kg DMH, 70% of the animals with cholecystectomy developed carcinoma. Only 16% of the mice with similar treatment but without cholecystectomy had carcinoma. The cocarcinogenic effect of cholecystectomy is assumed to be due to the increased production of secondary bile salts by the colonic bacteria and the lacking of the resorptive function of the gallbladder for some carcinogenic substances passing through the liver. The background of this experimental studies are the clinical findings that 10% of patients with carcinoma of the large bowel had previous cholecystectomy.

Animals↗
PubMed1977

New technique for endoscopic treatment of bleeding gastric ulcer.

In two patients with bleeding gastric ulcer hemorrhage could be stopped by submucous infiltration around the lesion without any complication. This simple method using a selfconstructed needle seems to guarantee good results especially in bleeding little arteries. Infiltration was performed with a 1.5% solution of Aethoxysklerol (Kreussler, Wiesbaden-Biebrich) using 3-5 ml totally for treatment.

Adult↗
PubMed1977

A case of severe compression of the coeliac artery.

A man, aged 42 years, presented as an emergency with a history of stabbing upper abdominal pain, nausea and diarrhoea of two weeks' duration. Apart from abnormal transaminase and alkaline phosphatase values, the routine clinical and laboratory examinations did not reveal any abnormality. As the abdominal pain increased in severity, particularly in association with eating, and projectile vomiting supervened, aortography was carried out and showed severe stenosis of the coeliac axis, involving about 1 cm of the artery. At operation a thick fibrous band, which originated from the median arcuate diaphragm, was seen to constrict the point of origin of the artery and to compress the vessel against the aorta. The band was divided, whereupon the coeliac artery immediately showed strong pulsations and adequate filling. Microscopic examination of the fibrous band revealed, among other structures, those characteristic of a ganglion. The symptoms disappeared after operation.

Adult↗
PubMed1977

[The role of ERCP in the diagnosis and indication for surgical treatment of diseases in the region of the papilla Vateri (author's transl)].

Duodenoscopy with transpapillar examination of biliary and pancreatic ducts has become an important branch in diagnosing gastroenterologic diseases. This will almost guarantee more exact information especially concerning indications and technique in diseases of the biliary tract and pancreas. Better results of operative treatment might be expected in future.

Ampulla of Vater↗
PubMed1976

[Experimental study on the pathogenesis of anastomotic ulcers (author's transl)].

Various forms of operative duodenal exclusion with or without duodenogastric reflux were performed on 54 male Wistar rats. It was demonstrated that after duodenal exclusion with reflux peptic ulcers regularly occur at the site of anastomosis. Continuous reflux of bile and pancreatic secretion is the decisive factor in the development of ulcer at the anastomotic border between stomach and jejunum. Stasis in the excluded duodenum (syndrome of the afferent loop) promotes the ulcerogenic reflux effect. If there is no pylorus, reflux and stasis are potentiated to the highest incidence of ulcer (more than 90%). These results indicate that operations with duodenal exclusion and reflux (Billroth II) should be discontinued.

Animals↗
PubMed1976

[A special closure system of the gastrointestinal tract of the rat (author's transl)].

As a result of animal experiments, morpho-histologic and surgical findings, the presence of a new closure system of the gastrointestinal tract is described. The mode of action is different from that of all the known muscle sphincters. It is found in the ascending colon of the rat and consists of a specially arranged and adjustable mucosal folds with aunique vascularisation. A functional unit which comosed of a pair of folds and a vascular plexus constitute the valvular mechanism. We, therefore, consider appropriate to call it the Angioplical Closure System. Surgical reversion of even a very small portion of the system causes a lethal ileus.

Ampulla of Vater↗
PubMed1976

[Morphology and physiopathology of Billroth I gastroduodenostomy].

97 patients subjected from 1 to 7 years previously to partial gastric resection by gastroduodenostomy (Billroth I) have been studied endoscopically and radiologically. Acid secretion after pentagastrin injection has also been determined. The most frequent mucous alterations identified by endoscopy were erosions in the stomach residue with inflammatory granulation in the anastomosis region. Recurrent ulcers were observed in 3% of cases. Acid secretion was reduced in 87% by comparison with the preoperative picture. The quantity of residual recretion depended on the greater curvature of the residual stomach. Radiological studies highlighted functional modifications indicative of organized motility in the residual stomach and pseudopyloric function at anastomosis level making coordinated draining possible.

Follow-Up Studies↗
PubMed1976

Ossification in cancer of the stomach: an experimental study.

In rats with Nitrosoguanidine induced carcinomas of the gastric stump, heterotopic ossifications are found freqently. The following stages of differentiation during the desmal ossification in the stump carcinomas are demonstrated: 1. Osteoblasts, 2. Osteoid, 3. Woven bone, 4. Lamellar bone. --The islands of metaplastic bone cells are predominantly located in the invasive marginal zone of the carcinoma of the gastric stump. The histology of the heterotopic ossification in the gastric stump of the rat is similar to that one seen in stomach cancer of men. The model here described seems to be suitable for further study of metaplastic bone formation in the gastrointestinal tract.

Adenoma↗
PubMed1976

Susceptibility of the resected stomach to experimental carcinogenesis.

The purpose of this study was to find whether gastric resection enhances the incidence of carcinoma in the remaining part of the stomach. 66 male Wistar rats were subjected to stomach resection according to the Billroth I or the Billroth II method. These rats, as well as control animals with intact stomachs, were fed the carcinogen N-Methyl-N'-nitro-N-nitrosoguanidine (NG). -- 25 of 66 animals developed carcinomas in the gastric remnant. Precancerous lesions were seen in 18 rats. The tumours were characterized histologically as adenocarcinomas. They were almost exclusively localized in the region of the gastroenteral anastomosis. The process of tumour formation in the resected stomach was completed within 17-31 weeks on continuous administration of NG in a concentration of 120 mg/l in the drinking water. In contrast to these findings, the development of cancer in the intact stomach required on average 41 weeks under the same conditions of NG administration. However, with regard to the incidence of malignant changes, no significant difference was observed between animals undergoing the Billroth I method and those undergoing the Billroth II method.--The results suggest that the resected stomach of the rat is more susceptible to induction of cancer than the intac one. Exposure of the resected stomach to an oral carcinogen induces carcinogenesis predominantly in the anastomotic region.

Adenocarcinoma↗
PubMed1976

[Morphology and pathophysiology of Billroth I gastro-duodenostomy (author's transl)].

Endoscopic and radiological studies were undertaken in 97 patients who had had a partial gastric resection with gastro-duodenostomy (Billroth I) one to seven years previously. Acid secretion was also analyzed after injection of pentagastrin. The most frequent mucosal changes seen at endoscopy were erosion in the residual stomach, with inflammatory granulation in the region of the anastomosis. Recurrent ulcers were seen in 3%. Acid secretion was reduced by 87% from its pre-operative level. The amount of residual secretion depended on the length of the greater curvature in the residual stomach. Radiological studies revealed functional changes indicating that there is a motility pattern in the residual stomach and a pseudopyloric function at the anastomosis which makes co-ordinated emptying possible.

Follow-Up Studies↗
PubMed1976

Transmission of hepatitis B associated with hemodialysis: role of malfunction (blood leaks) in dialysis machines.

In the first 10 months of 1974, 26 of 60 susceptible patients in a commercial hemodialysis unit developed asymptomatic infection with hepatitis B virus; 17 (65%) of the 26 cases occurred in 14 weeks from July to October. In a case-control study, 15 of 16 cases for whom records were available were found to be associated with malfunctions of dialysis machines (primarily leaks or ruptures in dialysis membranes) that had occurred before patients converted to hepatitis B surface antigen (HBs Ag) positivity. In comparison, 17 of 34 controls were associated with machine malfunctions (P less than 0.01). In addition, the mean number of malfunctions in machines per patient was significantly greater for cases of infection (2.25 +/- 1.34) than for controls (1.06 +/- 1.39) (P less than 0.01). Furthermore, a direct correlation was demonstrated between an increase in blood leaks in machines used with susceptible patients and subsequent increases in cases of hepatitis for the various beds in the unit (r=0.994, P less than 0.0001). The mean period from the last blood leak to HBs Ag seroconversion was 67 days. Six of the 36 blood leaks associated with cases of infection occurred less than 6 hr after leaks in the contaminated area, whereas only one of 36 leaks associated with controls demonstrated this relationship (P less than 0.05). These data suggest that the conversion to HBs Ag positivity was linked to the occurrence of machine malfunctions (blood leaks) and that events which occurred during these episodes caused the spread of infection.

Hepatitis B↗
PubMed1976

[Endoscopy of postoperative hemorrhage in the upper gastrointestinal tract].

In hemorrhages from the upper gastrointestinal tract, emergency endoscopy is becoming more and more significant. Hemorrhages during the early postoperative stage, particularly in abdominal surgery, require particular attention due to the generally difficult postoperative situation. In most instances, intragastral hemorrhages are due to erosions and anastomotic bleeding. A detailed knowledge of the surgery performed may contribute to a quick and successful examination. Among the most important premises for a high rate of correct diagnoses are the experience of the examining physician as well as an early or immediate identification of the indications. In addition to the diagnostic significance, under favorable circumstances endoscopy makes possible definitive or temporary staunching of the bleeding by means of diathermy, laser beam or sclerotization.

Endoscopy↗