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Biomedical subjects

B Sharma

Publications and source records attributed to B Sharma.

At least 91 records · Page 5Linked to original sources
PubMed1987

Demonstration of exercise-induced painless myocardial ischemia in survivors of out-of-hospital ventricular fibrillation.

To ascertain if myocardial ischemia is the mechanism of out-of-hospital ventricular fibrillation (VF), left ventricular (LV) function was assessed at rest and during submaximal exercise in 15 patients who survived out-of-hospital VF. They were separated into asymptomatic (9 patients, group A) and symptomatic (6 patients, group S) groups for a history of angina or myocardial infarction. Both groups had significant (at least 70% diameter stenosis) coronary artery disease. At catheterization no patient had angina during exercise, but 12 of 15 had ST depression or increased ST depression (group A, 1.9 +/- 1.4 mm; group S, 1.1 +/- 1.2 mm) and 11 had abnormal wall motion. From rest to exercise, patients in group S had increased LV end-diastolic pressure (from 21 +/- 9 to 37 +/- 11 mm Hg, p = 0.009) and volume (from 100 +/- 25 to 107 +/- 26 ml/m2, p = 0.006), with no significant change in LV ejection fraction (from 40 +/- 13 to 42 +/- 12%). In group A LV end-diastolic pressure increased from 19 +/- 4 to 31 +/- 8 mm Hg (p = 0.001), but neither end-diastolic volume nor ejection fraction changed significantly (from 83 +/- 13 to 92 +/- 23 ml/m2 and from 55 +/- 13% to 46 +/- 13%, respectively). Thus, patients with coronary artery disease who survive out-of-hospital VF may have evidence of myocardial ischemia during exercise without pain. Painless ischemia may have a role in out-of-hospital VF.

Adult↗
PubMed1987

Reverse phase passive haemagglutination test for the detection of rinderpest antigen.

Reverse phase passive haemagglutination [RPHA] test was applied for the detection of rinderpest antigen in various organs of rinderpest infected cattle. The results of RPHA were compared with counter immunoelectrophoresis [CIE] and single radial haemolysis [SRH] test. RPHA was as sensitive as CIE and SRH in detecting rinderpest antigen.

Animals↗
PubMed1987

Aortic dissection, a diagnostic dilemma: case report.

A case of type I (type A) aortic dissection proved by postmortem examination could not be fully delineated relative to the type of dissection by dynamic CT as well as three positive contrast aortograms. Small tears in the ascending aorta and their strategic locations can escape even intensive radiologic evaluation. We present a case in which medical therapy was provided and, inappropriately, surgery was not performed.

Aortic Dissection↗
PubMed1987

Application of solid phase aggregation of coated erythrocytes technique for detection of rinderpest antigen.

A solid phase aggregation of coated erythrocytes (SPACE) technique was standardized and used for the detection of rinderpest antigen in 129 samples of 9 visceral organs; from 50 clinical samples such as gum scraping, tongue scraping, faeces, urine, nasal swabs; blood from 18 rinderpest infected cattle and 2 field samples. The comparative sensitivity of SPACE, reverse phase passive haemagglutination and counter-immuno-electrophoresis tests was found to be 86.8, 84.5 and 79.8%, respectively.

Animals↗
PubMed1987

Serodiagnosis of Fasciola gigantica infection in buffaloes.

The agar gel precipitation test (AGPT), counter immunoelectrophoresis (CIEP) and indirect haemagglutination (IHA) were evaluated for the diagnosis of fascioliasis due to Fasciola gigantica in buffaloes. The sensitivity of these tests varied with the intensity of infection; and was greatest when the fluke burden in liver exceeded 100. CIEP detected 76.06% of infected sera and was most sensitive, followed by IHA which detected 68.37% of the infected sera. The AGPT was found to be least sensitive, detecting only 57.4% of the infected sera. Although these tests were limited by the occurrence of false-positive reactions, their use may be an aid for effective diagnosis of fascioliasis in buffaloes.

Animals↗
PubMed1987

Acid secretory capacity and plasma gastrin concentration after administration of omeprazole to normal subjects.

In a randomized double-blind study, two groups of eight healthy volunteers received either placebo or omeprazole 40 mg o.m. for 14 days. Fasting plasma gastrin concentration and peak acid output in response to a maximal intravenous dose of pentagastrin were measured before, during and after the 14 days of treatment. Omeprazole caused a 68% (mean) decrease in the peak acid output when measured 24 hours after the last dose, with a simultaneous increase in the fasting plasma gastrin concentration. When measured 1, 2, 3 and 8 weeks after cessation of treatment, there was no significant difference in the peak acid output between the two groups. The study demonstrates that there is no increase in the acid production capacity after 2 weeks of treatment with omeprazole. Thus it would appear that the rise in the plasma gastrin concentration during short-term treatment with omeprazole does not induce parietal cell hypertrophy or hyperplasia.

Adult↗
PubMed1987

Residual myocardial jeopardy in patients with Q-wave and non-Q-wave infarctions.

The correlation between the presence of areas of jeopardized myocardium and the electrocardiographic patterns of anterior and inferior Q-wave and non-Q-wave infarctions was studied in 486 patients who had had stable symptoms for at least six months after a single myocardial infarction. Myocardial jeopardy was identified on a ventriculogram in the right anterior oblique position if normal or hypokinetic wall motion was seen in all segments distal to a lesion that caused stenosis of greater than 50% and less than 100% in the proximal or mid left anterior descending coronary artery (anterior jeopardy), or in the proximal or mid right coronary artery or proximal circumflex coronary artery in a left dominant circulation (inferior jeopardy). Patients with non-Q-wave anterior infarctions had a significant increase in the frequency of jeopardized myocardium when compared with patients with Q-wave inferior or anterior infarctions. The group with non-Q-wave anterior infarction also had a significantly lower percentage of myocardial segments with absent wall motion in the area of infarction than all other groups. This combination of coronary narrowing with retained wall motion may contribute to the increased frequency of reinfarction seen in some studies of non-Q-wave infarction.

Adrenergic beta-Antagonists↗
PubMed1987

Serodiagnosis of fascioliasis in buffaloes by immunoprecipitation using adult Fasciola gigantica antigens.

Partial purification of a saline extract of adult Fasciola gigantica by chromatography on Sephadex G200 gave four peaks, of which only the first two contained material which gave a precipitation reaction with sera from infected buffaloes. None of these gave false reactions with sera from uninfected animals but even the first and most sensitive fraction only reacted with 57.5 per cent of sera from animals known to be infected with moderate numbers of F gigantica.

Animals↗
PubMed1987

Haematological studies on Indian pashmina goats.

Haematological studies were conducted on 61 clinically normal pashmina producing goats of the Cheghu breed, acclimatised to the temperate, humid climatic condition of Mukteswar, about 2400 m above sea level. The experimental goats comprised four age groups (birth to one month, six to nine months, three to five years and six to 10 years) of both sexes. The overall values, irrespective of age and sex, for the parameters examined were: red blood cells, 14.17 +/- 1.96 X 10(12) litre-1; haemoglobin, 7.46 +/- 0.79 g dl-1; packed cell volume, 0.31 +/- 0.04 litres litre-1; mean corpuscular volume, 21.62 +/- 2.46 fl; mean corpuscular haemoglobin concentration, 23.72 +/- 1.80 g dl-1; mean corpuscular haemoglobin, 5.11 +/- 0.67 pg; erythrocyte sedimentation rate, 0.00 mm at one hour; plasma protein 6.58 +/- 0.78 g dl-1; icterus index, 9.15 +/- 2.92 units; white blood cells 12.26 +/- 2.66 X 10(9) litre-1; absolute count of lymphocytes, 4.62 +/- 1.40; neutrophils, 5.91 +/- 2.84; monocytes, 0.38 +/- 0.15; eosinophils, 0.32 +/- 0.17 and basophils, 0.05 +/- 0.05 (X 10(9) litre-1). The sex of the animal did not affect the haematological parameters but the effect of age was evident. In newborn kids the haemoglobin, mean corpuscular haemoglobin and packed cell volume values were higher and the total leucocyte count was lower than in other age groups. As the kids grew older lymphocyte numbers decreased while neutrophils increased.

Age Factors↗
PubMed1986

Intracoronary prostaglandin E1 plus streptokinase in acute myocardial infarction.

Fourteen patients with acute myocardial infarction (duration of chest pain 5 +/- 2 hours) received intracoronary infusion of prostaglandin E1 (PGE1) and streptokinase. Intracoronary PGE1 was followed by intracoronary streptokinase in 10 patients (group A), with successful recanalization in all patients. Of 4 patients in whom recanalization failed with intracoronary streptokinase given first (group B), 2 had successful recanalization after addition of intracoronary PGE1. Immediately after successful recanalization, left ventricular ejection fraction increased from 50 +/- 9% to 62 +/- 10% (p less than 0.0008), left ventricular end-diastolic pressure decreased from 20 +/- 10 to 16 +/- 10 mm Hg (p less than 0.05) and stroke volume index increased from 34 +/- 10 to 44 +/- 12 ml/m2 (p less than 0.02). Infarct segment shortening improved from 9 +/- 5 to 18 +/- 4% (p less than 0.0002). Transient hypotension in 1 patient was the only complication. Follow-up catheterization in recanalized patients at 2 to 10 days showed maintained improvement in left ventricular global and infarct segment function. Reocclusion occurred in 1 patient. Thus, intracoronary infusion of PGE1 was effective in establishing reperfusion in all patients when followed by streptokinase and was associated with immediately improved left ventricular global and regional function. PGE1 deserves further evaluation in acute myocardial infarction.

Adult↗
PubMed1986

Single radial hemolysis test for the detection of rinderpest antibody.

The single radial hemolysis [SRH] test was employed for detection of rinderpest antibodies in post-vaccinated serum samples as also in serum samples from animals recovered from rinderpest infection. The results were compared with counterimmunoelectrophoresis [CIE] and serum neutralisation [SN] tests. The CIE test was found to be more sensitive than SRH but because of ease and simplicity SRH can also be used for monitoring antibody development after vaccination.

Animals↗
PubMed1986

Acute myocardial infarction associated with DF-2 bacteremia after a dog bite.

This is the first reported case of an acute myocardial infarction probably secondary to DF-2 bacterial septicemia and presumed endocarditis. Selective coronary arteriography revealed a long filling defect causing 95% stenosis of the second diagonal branch of the left anterior descending coronary artery. Multiple blood cultures revealed Decarboxylase Fermentor-2 (DF-2) septicemia that responded to penicillin therapy. Two months status after myocardial infarction recatheterization revealed complete recanalization with slight irregularity of the vessel lumen at the site of previous obstruction.

Adult↗
PubMed1986

Free and erythrocyte-bound bilirubin in neonatal jaundice.

Serum free bilirubin and erythrocyte-bound bilirubin concentrations were estimated in 53 jaundiced neonates with a total serum bilirubin concentration of 227.4 +/- 80.4 mumol/l. The serum free bilirubin and erythrocyte-bound bilirubin concentrations were 8.7 +/- 5.6 nmol/l and 23.8 +/- 6.0 mumol/l, respectively. Both, the serum free bilirubin (r = 0.741, p less than 0.001) and erythrocyte-bound bilirubin (r = 0.754, p less than 0.001) correlated directly with bilirubin-albumin molar ratio. There was a direct correlation between free and erythrocyte-bound bilirubin concentration (r = +0.657, p less than 0.001). The prediction of serum free bilirubin concentrations from the known erythrocyte-bound bilirubin value was unreliable.

Bilirubin↗