Biomedical subjects
Publications and source records attributed to B Risberg.
The formation of debris in human blood, stored under standard blood bank conditions, was investigated by measuring debris weight, screen filtration pressure (SFP) and counting the number of aggregates. Formation of microaggregates was most pronounced in blood five to fifteen days old as was the SFP. A tendency of progressive increase was found in debris weight with storage time.
A review of the symptoms and signs as well as preoperative investigations was made in 12 patients with proved colovesical fistulas. The symptoms were predominantly those of the lower urinary tract. The value of barium enema, cystogram, cystoscopy and sigmoidoscopy was pointed out. Treatment consisted of a combined treatment with colostomy and indwelling bladder catheter, primary closure of the fistula only and various staged procedures with bowel resection. We emphasize the value of the one-stage procedure in the uncomplicated case.
A family with a remarkable aggregation of malignant mesothelioma is described. The father, 3 brothers, and a sister all died of the condition. The family and epidemiologic histories are reviewed. Random occupational asbestos exposure in the building industry probably occurred in 4 of the 5 cases. All of the patients were smokers. There is a low incidence of malignant mesothelioma in the area where they resided. These observations suggest that over and above the smoking and asbestos exposure, heredity may be an important predisposing factor in the genesis of this tumor.
Tissue fibrinolysis in the stomach and intestine of the rat was studied with a histochemical technique. After perfusion of blood vessels to reduce the influence of circulating plasminogen activator and inhibitor fibrinlysis was localized mainly to submucosal arteries and to the serosa of the gastrointestinal tract. This is opposite to previous observations, in which tissue fibrinolysis in the gastrointestinal tract was suggested to be mainly localized to veins. A method for semiquantitative analysis of tissue fibrolysis in the rat stomach is described.
An optimal inhibition of tissue fibrinolysis, studied by a histochemical fibrin slide technique in the rat stomach, was obtained by administration of tranexamic acid in a dose of 60 mg/100 g body weight. A significant fibrinolysis inhibition was found within 5 min, when tranexamic acid in this dose was given either intravenously or intragastrically. A prolonged duration of fibrinolysis inhibition was observed after intragastric administration. After 4 hr no inhibitory effect of tranexamic acid could be recorded, irrespective of the route of administration.
Tissue fibrinolysis in the rat stomach and transverse colon was studied after X-ray irradiation of the abdomen. Tissue biopsies were examined on unheated fibrin plates and with a histochemical technique modified from Todd. A significantly increased fibrinolytic activity was found in the mucosa of the stomach and colon 3 days after irradiation, while fibrinolysis localized to submucosal vessels was unchanged. Mucosal fibrinolysis in the stomach was significantly inhibited by intragastric administration of tranexamic acid.
Screen filtration pressure (SFP), quantity of microaggregates and debris weight were measured in stored human blood. The number of aggregates correlated with the debris weight but not with SFP. No correlation was seen between the debris weight and SFP. The mechanisms behind and the functional importance of these findings are outlined.
The cascade systems - the coagulation, fibrinolytic, kallikrein-kinin and complement systems - are all activated after trauma. These systems are involved in the post-traumatic pulmonary reaction. The complexity with which all the systems are intimately related is stressed. The specific role of the different systems in the development of post-traumatic pulmonary insufficiency remains to be evaluated.
The records of 82 patients with vascular trauma, treated at the Departments of General Surgery of the Sahlgren's Hospital, Göteborg, between 1969-1978 were revised. Nine patients were female and 73 male. The most common type of trauma was stab wounds. The overall mortality was 10.9%, all being patients with major vascular trauma and/or multiple injuries. Fourteen cases were due to iatrogenic lesions. Of the remaining 68 patients, minor vessels were traumatized in 40 cases, and treated with ligation. In 28 patients some kind of reconstructive procedure was attempted, 23 of these patients survived. All reconstructive procedures in surviving patients were successful. In comparison with international experience, vascular trauma in Sweden seems to be very uncommon.
The fibrinolytic activity in autologous artery and vein grafts was studied in cats during a 4-month period. The fibrinolytic activity in the wall of an aortic segment interposed in the caval vein was increased in comparison to the normal aorta. In the corresponding segment of the caval vein interposed in the aorta, the fibrinolytic activity was reduced during the observation time. Thrombosed segments had a decreased activity. No changes were seen in sham operated animals. The plasminogen activator activity in the vessel wall was found to be influenced by the surrounding milieu.
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A patient who 5 years previously had an aortoiliac reconstruction with a dacron graft developed intestinal bleeding. At laparotomy this was found to be due to a fistula between a pseudoaneurysm at the right iliac artery anastomosis and the appendix. Resection of the aneurysm and adjacent parts of artery and graft with additional appendectomy prevented further intestinal bleeding. A search of the literature produced only one previously reported case similar to this.
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Explore the source record for details and available documents.
Explore the source record for details and available documents.
A 52-year-old woman with vaginal bleedings had hysterectomy because curettings prompted suspicion of malignancy. A uterine tumour with deep infiltration of trophoblastic cells in the myometrium was revealed. Postoperative quantitative analysis for urinary human choriongonadotropin gave 1500 IU/1. The patient got no other treatment and is well 3 years after operation. The histopathological picture and the clinical course were consistent with the recently introduced diagnosis of benign "trophoblastic pseudotumour", which should perhaps replace the old terms "syncytioma" and "chorionepitheliosis".
Recent progress in animal and human research on the effect of trauma on the fibrinolytic system is reviewed. The normal balance between activating and inhibiting mechanisms is stressed. Some pathophysiological implications of trauma induced alterations in the fibrinolytic system are presented.
The technique for transposition of infrarenal segments from the abdominal aorta and the caval vein, respectively, was described and morfological changes characterized. The vessel walls in the transposed caval segments became "arterialized" 1 month after the operation due to increased connective tissue in the media. Fibrin depositions were found on the intimal layer. The transposed aortic segments had no morfological changes. The described model was found to be a simple and valuable method for vascular research in small animals.