Micropore filtration of transfused blood.
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Biomedical subjects
Publications and source records attributed to B Risberg.
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Intravenous injection of a tumour cell suspension in rats induced an early tendency to increased fibrinolysis followed by a temporarily, significantly decreased fibrinolytic activity in lung vessels. These reactions were similar to those previously found after a large trauma and might reflect the vascular reaction to thrombotic material trapped in the lung microcirculation.
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Previous experimental data suggested a pronounced inhibition of the spontaneous intravascular tumor cell shedding by induced antifibrinolysis. Furthermore, the growth rate of primary tumours was reduced. This initiated the present investigation, in which the effect of antifibrinolysis, induced with tranexamic acid, on the per-operative intravascular release of cells from a 20-methylcholanthrene induced rat sarcoma was studied. Tumour cell shedding was estimated by registration of the outgrowth of secondary tumours in animals transplanted intrasmuscularly or intravenously with blood from the operatively treated tumour area. Induced antifibrinolysis was not found to influence the intravascular shedding of tumour cells. However, a significantly increase release of tumour cells was found during biopsies on large primary tumours compared to the same operative procedure on small tumours.
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The records of 57 patients with abdominal stab wounds, treated at the Surgical Departments of the Sahlgrenska Hospital, Göteborg, between 1969-1974, were revised. Fifty-five patients were males and 2 females. The wounds were situated in the upper abdomen in 72% of the patients. Forty-nine patients were treated with an explorative laparotomy and the findings were considered to be negative in 31% of these patients. Liver injuries were found in 45% of the operated patients. No complications occurred in the patients with negative laparotomy findings. One patient with multiple intra-abdominal lesions succumbed from an irreversible septic shock.
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