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Biomedical subjects

B Newman

Publications and source records attributed to B Newman.

At least 253 records · Page 14Linked to original sources
PubMed1978

A comparison of the effects of single doses of mianserin and amitriptyline on psychomotor tests in normal volunteers.

Eight healthy volunteers received single doses of either mianserin 10 mg, mianserin 20 mg, amitriptyline 25 mg or placebo. Critical flicker frequency, reaction time, digit substitution and addition times were tested up to six hours afterwards. Mianserin 20 mg and amitriptyline 25 mg significantly prolonged reaction time and mianserin 10 mg and 20 mg significantly reduced critical flicker frequency. No other significant effects were found. Patients should be warned of possible sedation when first starting treatment with mianserin.

Amitriptyline↗
PubMed1976

Surface sulphydryl groups and phagocytosis-associated oxidative metabolic changes in human polymorphonuclear leucocytes.

The role of surface sulphydryl (-SH) groups of human polymorphonuclear leucocytes on phagocytosis-associated oxidative metabolic changes was studied. p-Chloromercurybenzene sulphonic acid, a surface -SH group inhibitor, had no effect on phagocytosis, superoxide production during phagocytosis, or killing of S. aureus by the leucocytes, while it inhibited phagocytosis-associated stimulation of hexose monophosphate pathway activity and H2O2 production. In contrast, N-ethylmaleimide, which inhibits both intracellular and surface -SH groups, inhibited phagocytosis-associated oxidative metabolic changes. p-Chloromercurybenzene sulphonic acid also inhibited the stimulation of hexose monophosphate pathway activity by exogenous H2O2, suggesting a regulatory role of plasma membrane on the pathway's activity in human polymorphonuclear leucocytes. The results also suggest that: (I) superoxide production is the primary event of oxidative metabolic changes during phagocytosis, (2) superoxide plays an important role in the killing of S. aureus, and (3) the hexose monophosphate pathway plays a primary role in producing NADPH for H2O2 production from superoxide.

4-Chloromercuribenzenesulfonate↗
PubMed1976

Surface sulphydryl groups and hexose monophosphate pathway activity in resting human polymorphonuclear leucocytes.

The role of surface -SH groups on the hexose monophosphate pathway activity in resting human polymorphonuclear leucocytes was studied. Endotoxin, taurocholic acid and concanvalin A stimulated [I-14C]glucose oxidation to a greater degree than [6-14C]glucose oxidation. The stimulation of glucose-I-C-oxidation by endotoxin, taurocholic acid and concanavalin A could be prevented by p-chloromercurybenzene sulphonic acid, an inhibitor of surface -SH groups. In contrast, polymorphonuclear leucocytes from four patients with chronic granulomatous disease failed to show stimulation of glucose-I-C-oxidation by endotoxin, taurocholic acid or concanavalin A.

4-Chloromercuribenzenesulfonate↗
PubMed1976

Effects of mitogens on glucose oxidation by lymphocytes from normal individuals and patients with chronic lymphocytic leukemia.

The effects of phytohemagglutinin (PHA), concanavalin a (con A) and endotoxin on glucose oxidation by lymphocytes from normal individuals and patients with chronic lymphocytic leukemia (Cll) were demonstrated without using tissue culture techniques. PHA and CON A had no effect on glucose-6-14C oxidation, but stimulated glucose-1-14C oxidation by normal lmphocytes. This stimulation of glucose-1-14C oxidation occurred within 1 hour and could be prevented by colchicine. In contrast, endotoxin had no effect on either gucose-I-14C or glucose-6-14C oxidation by normal lymphocytes. Lymphocytes from five out of six Cll patients showed low basal rate of gucose-1-14C oxidation by the lymphocytes of these five patients.

4-Chloromercuribenzenesulfonate↗
PubMedDate not supplied

Intrapericardial left atrial aneurysm: noninvasive diagnosis.

Intrapericardial aneurysm of the left atrium is a rare cardiac anomaly. We present a 10-year-old girl in whom the diagnosis was made following referral for an abnormal configuration of the left heart border seen on chest radiography. Diagnosis was made by echocardiography, but magnetic resonance imaging defined the exact morphology and the relation to adjacent structures. Surgical removal of this aneurysm is recommended because of potentially serious complications.

Child↗