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Biomedical subjects

B Lebeau

Publications and source records attributed to B Lebeau.

At least 163 records · Page 9Linked to original sources
PubMed1977

[Prognosis for bronchial epidermoid carcinoma treated by surgery--report of 102 cases].

The retrospective study of 102 epidermoid carcinomas of bronchial radically treated by surgery enables a survey of various prognostic factors, assessing the post-operative evolution over 2 years for 98 patients and over 5 years for 68 others. Some signs are ominous: chest pains or a worsening general condition in the preoperative symptomatology. On the other hand, the effect of the delay between the first symptoms and the intervention has not been demonstrated. Two factors, so far not much valued, have also been studied: the condition of the bronchial section of little prognostic value and, on the other hand, the TNM systematic classification which seems valuable for all operated bronchial cancers.

Adult↗
PubMed1976

[The role and functions of the lung in equilibrium of the internal milieu. Protein metabolism and enzyme systems].

The different anatomical zones of the lung show a high degree of variation in metabolic function, involving many protein molecules and complex enzyme systems. Recent data in the literature concerning such activity are described with respect to bradykinin, fibrinolysis, haemostasis, angiotensin, serotonin, catecholamines, prostaglandins, vaso-active amines, the protease-antiprotease system and benzopyrene-hydroxylase.

Capillaries↗
PubMed1976

[A case of Wegener's syndrome with a long evolution].

Presentation of a case of Wegener syndrome with two remarkable atypisms: multiple visceral localizations and evolution lasting over 17 years without any chemotherapy. Discussion of these abnormalities, particularly of the importance, in this slow evolution, of an early exeresis of the granuloma in the upper airways.

Autopsy↗
PubMedDate not supplied

Prognostic factors from a randomized clinical trial in resected lung cancer.

Prognostic information has three main uses: prediction of the course of evolution of disease, decisions about treatment and limitation of complementary tests. Using data from a randomized controlled clinical trial of immunotherapy in resected lung cancer, we identified factors of prognostic importance. In particular we demonstrated that a time-consuming and expensive cell-mediated immunity test is not of prognostic value. Our cooperative group decided to cancel this test in the routine examination of patients with resected lung cancer. Disease stage was confirmed as the main prognostic factor.

Clinical Trials as Topic↗
PubMedDate not supplied

Computed tomography of mediastinal lymph nodes in nonsmall cell lung cancer. A new approach based on the lymphatic pathway of tumor spread.

Computed tomography was used to evaluate mediastinal lymph nodes in 97 patients with nonsmall cell lung cancer. All patients had thorough surgical-pathological determination of mediastinal node status. Twenty-three patients were found to have metastatic lymph nodes. The usual lymphatic pathways of tumor spread into the mediastinum were defined using the node mapping scheme suggested by the American Thoracic Society. We considered mediastinal nodes abnormal when the short axis of the largest mediastinal node in the lymphatic drainage territory of the cancer was greater than or equal to 10 mm and the difference between this node and the largest node in the other territories is greater than 5 mm. The sensitivity was 78%, the specificity 99%, the positive predictive value 95%, the negative predictive value 94%, and the accuracy 94%. Comparing our method to those that used the size criterion alone, the number of false positives was reduced.

Adult↗
PubMedDate not supplied

Itraconazole in the treatment of aspergillosis: a study of 16 cases.

Itraconazole, a new triazole antifungal agent, has marked in vitro activity against filamentous fungi, particularly Aspergillus. We studied three groups of patients suffering from aspergillosis (16 cases): six affected with aspergilloma, three with allergic bronchopulmonary aspergillosis and seven with invasive aspergillosis. The survey consisted in clinical, radiological, mycological and serological evaluations with respect to drug plasma levels. Itraconazole was given at a dosage of 200-400 mg day-1 for periods ranging from 14 to 488 days. Out of the 16 patients, nine responded to therapy (recovery or improvement) and one failed to respond. Three patients improved but experienced relapses and three others could not be evaluated because of liver function disorders, so that treatment had to be stopped prematurely.

Adolescent↗
PubMedDate not supplied

Specific antibody detection in human aspergillosis: a GEMO* multicentre evaluation of a rapid immunoelectrophoresis method (Paragon). Group d'Etude des Mycoses Opportunistes.

A new immunoelectrophoresis system, the Paragon system, was evaluated in three different hospital centres with the aim of improving standardization of the serodiagnosis of human aspergillosis. To select the most efficient antigen, various commercial and home-made antigens were first tested on 19 sera from 19 patients with highly probable aspergillosis. The value measured using the Paragon anti-Aspergillus antibody detection system was then compared with the results obtained by conventional serological diagnostic methods (conventional immunoelectrophoresis, enzyme linked-immunosorbent assay, indirect immunofluorescence): this step was performed using the first 19 sera as well as 16 other sera from 13 patients with suspected aspergillosis. Concordant results were obtained in 28 cases. The discrepancies observed with seven sera were probably related to differences in the nature of the antigens. Paragon immunoelectrophoresis proved to be a practicable technique requiring only a small amount of serum and giving results within a shorter time than competitive methods (24-48 h). Its major drawbacks compared with conventional immunoelectrophoresis are some difficulties in reading, fewer precipitin lines and the relatively high cost of routine analysis.

Antibodies, Fungal↗