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Biomedical subjects

B K Sharma

Publications and source records attributed to B K Sharma.

At least 145 records · Page 8Linked to original sources
PubMed1987

Possible HLA influence in governing susceptibility to non-cirrhotic portal fibrosis.

Forty-eight unrelated North Indian patients with non-cirrhotic portal fibrosis were studied for the distribution of HLA-A, B and DR antigens. No significant differences were observed in the distribution of HLA-A and B locus antigens. In the DR locus, the frequency of DR3 was significantly increased in the patients as compared to the controls (71.7% vs 26.1%, X2 = 25.3), while HLA-DR2 was significantly reduced (X2 = 11.3). Another striking observation was the presence of DR7 in all males negative for HLA-DR3. The results suggest an autoimmune pathogenesis of the disease and that susceptibility to non-cirrhotic portal fibrosis may be HLA class II mediated, with HLA-DR3 influencing susceptibility and DR2 conferring protection. Other genetic factors are also involved.

Gene Frequency↗
PubMed1987

Effect of contraceptives on the adhesion of Escherichia coli to uroepithelial cells.

We studied the effect of female ovarian hormones present in contraceptive preparations on six strains of Escherichia coli isolated from patients with urinary tract infections. These strains had variable attachment potential. To study this effect in vivo, we gave a woman an oral contraceptive preparation and then compared the amount of attachment to her uroepithelial cells before and after hormone administration. To study the in vitro effect, we exposed uroepithelial cells from this same woman to different hormone concentrations for up to 18 hr and noticed any alteration in adhesion. We observed that in vivo as well as in vitro exposure of uroepithelial cells to hormones enhanced the adhesion of all E. coli strains.

Adult↗
PubMed1987

Double-blind, randomized, cross-over clinical trial of metoprolol and propranolol in mild to moderate essential hypertension.

Thirty-two patients with mild to moderate essential hypertension completed this double-blind cross-over clinical trial of propranolol and metoprolol. Metoprolol was found to be as effective and safe as propranolol in lowering the systolic and diastolic blood pressure in both supine and standing positions. The mean fall in blood pressure was greater in the group which received metoprolol as the first treatment, as compared to the group which received propranolol as the first treatment. The side-effects produced by both drugs were mild and did not require discontinuation of therapy except for 2 patients who were on metoprolol. One patient who was controlled diabetic developed severe weakness and the other patient developed bronchospasm. Metoprolol did not produce any central nervous system related side-effects.

Adult↗
PubMed1987

Drug utilization studies in internal medicine.

An appraisal of the prescribing trends in the outpatients and inpatients, was done in the Department of Internal Medicine of Nehru Hospital attached to the Postgraduate Institute of Medical Education & Research, Chandigarh. Prescriptions of 162 outpatients and 78 inpatients were audited under heads of total number of drugs prescribed, proprietary/nonproprietary drug prescribing; choice of drug, its dosage, dosage form, interdosage interval and duration of prescription. Good standards of scientific therapeutics were found in general. Some lacunae are discussed.

Drug Prescriptions↗
PubMed1987

Acute isoniazid toxicity--report of 2 cases and review of literature.

Accidental or intentional isoniazid (INH) overdose is not uncommon. Two patients suffering from pulmonary tuberculosis ingested INH (9 g and 12 g respectively) intentionally following acute personal stress. One patient presented with oliguria and coma whereas seizures were the dominant feature in the second case. Serum levels of INH were high in both cases. Satisfactory clinical recovery followed after the administration of intravenous pyridoxine. Literature on the subject was reviewed and the manifestations and recommendations for the management of acute INH toxicity are highlighted.

Acute Disease↗
PubMed1986

Experimental haematogenous pyelonephritis in mice with uropathogenic, enteropathogenic and enterotoxigenic Escherichia coli.

Acute haematogenous pyelonephritis was produced with known uropathogenic (075), enteropathogenic (0111) and enterotoxigenic (H10407) Escherichia coli in mice. The enterotoxigenic E. coli showed the highest bacterial counts in kidney and urine and was found to have the same potential for causing pyelonephritis as a known pyelonephritogenic strain both in untreated and corticosteroid treated mice. Enteropathogenic E. coli was found to be less pyelonephritogenic in untreated mice, but under the effect of corticosteroids it showed similar pyelonephritogenic potential.

Animals↗
PubMed1986

Intrarenal gas abscess.

Intrarenal abscess owing to gas-forming gram-negative bacteria is rare. Female patients and diabetics, or those with urinary calculi or obstructive uropathic conditions commonly are affected. We report on a nondiabetic man who was infected with Pseudomonas aeruginosa. Initial medical management and subsequent partial nephrectomy offered cure.

Abscess↗
PubMed1986

Extramedullary haemopoiesis in the small bowel.

A patient with myelofibrosis developed repeated gastrointestinal haemorrhage from the small intestine, which was found to be infiltrated with extramedullary haemopoiesis. Nineteen months later he presented with subacute intestinal obstruction; radiology and laparotomy documented progressive infiltration of the small bowel. Histological examination of the resected terminal ileum showed patchy mucosal ulceration, with underlying submucosal and serosal extramedullary haemopoiesis.

Gastrointestinal Hemorrhage↗