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Biomedical subjects

B K Sharma

Publications and source records attributed to B K Sharma.

At least 163 records · Page 9Linked to original sources
PubMed1986

Twenty-four hour intragastric acidity during treatment with oral omeprazole.

In a series of 59 experiments on nine duodenal ulcer patients, 24-hour intragastric acidity was measured before, during and after treatment with daily oral omeprazole. Omeprazole, 10, 20, ro 30 mg/day for 1 week, caused a 37%, 90%, and 97% decrease respectively of 24-hour intragastric acidity. No further decrease of acidity was observed when the dose of omeprazole was doubled to 60 mg/day, or after a second week of treatment with 30 mg/day. One week after stopping treatment with omeprazole (14 doses), there was still a significant 26% decrease of 24-hour intragastric acidity, with full recovery 7 weeks later. Fasting plasma gastrin concentration was significantly elevated during treatment with all doses of omeprazole. The optimal dose of omeprazole is 30 mg/day for a maximal decrease of 24-hour intragastric acidity in duodenal ulcer patients.

Adult↗
PubMed1986

Comparative effect of propranolol and labetalol on isometric exercise and cold stress induced increase in arterial blood pressure.

The effect of propranolol and labetalol on cold stress and isometric exercise induced rise of blood pressure was studied in 7 patients with essential hypertension and 14 normal volunteers in a controlled, double blind, randomized, cross-over trial design. The subjects received either propranolol (40 mg) or labetalol (100 mg) orally after breakfast. In patients of mild to moderate essential hypertension, labetalol reduced significantly both systolic as well as diastolic rise of blood pressure induced by both types of exercises. Propranolol only reduced the rise of systolic blood pressure significantly. In normotensive subjects, labetalol reduced significantly the rise in systolic as well as diastolic blood pressure induced by cold stress, but not by the isometric exercise, while propranolol only reduced significantly the rise in systolic blood pressure induced by both the tests. The rise in heart rate was more with isometric exercise than with cold stress both in hypertensive patients and control subjects. The heart rate rise was significantly reduced by propranolol in all the experiments except for the rise induced by cold stress in hypertensive patients. The changes in heart rate produced by labetalol were not significant.

Adult↗
PubMed1986

Low-dose captopril alone and in combination with hydrochlorothiazide in the treatment of mild to moderate essential hypertension.

In this open, titrated dose clinical trial, captopril, when used in small doses (up to 150 mg daily) for 8 weeks (n = 5) and 4 months (n = 13) in patients suffering from mild to moderate essential hypertension, produced a fall in blood pressure both systolic and diastolic. The end point viz. supine diastolic blood pressure of 90 mmHg or less was reached in 6 out of 18 patients with captopril alone and in another 4 patients after the addition of hydrochlorothiazide (25 mg to 50 mg daily). In 4 more patients, a good response was observed but the end point was not reached. The response was fair in 1 and poor in 3 remaining patients. The side effects produced were only mild in nature and did not require any change in dosage schedule. No significant changes were produced in serum electrolytes, creatinine and blood counts.

Adult↗
PubMed1985

Disseminated infection associated with corticosteroid therapy after transduodenal sphincteroplasty.

Treatment with oral prednisolone appears to have precipitated an episode of ascending cholangitis in an asymptomatic 55-year-old patient. He had undergone a Pólya partial gastrectomy, a cholecystectomy and a sphincteroplasty 19, 6 and 2 years earlier, respectively. The cholangitis was complicated by septicaemia with six different enteric organisms including aerobes and anaerobes. He developed liver and lung abscesses, and an indolent Pseudomonas aeruginosa septic arthritis of both hip joints. The patient eventually made a complete recovery, but required surgical replacement of both hips.

Ampulla of Vater↗
PubMed1985

Septilin and geriforte in allergic and vasomotor rhinitis.

Our study comprised 50 patients of allergic and vasomotor rhinitis. Seventeen patients gave history of stress and strain hence they were given Geriforte in addition to Septilin. The results of therapy were judged on following criteria: i) Symptomatic improvement. ii) Appearance of nasal mucosa before and after the therapy. Thirty-nine patients (78%) were cured 100% as they had total relief from symptoms along with change of nasal mucosa from bluish to pink. Eight patients (16%) had about 75% improvement and 3 patients (6%) had only 50% improvement. These patients were advised to continue the therapy for a longer time (6-8 weeks). Of these, 4 patients showed further improvement. In our opinion, Septilin has proved very useful in cases of allergic and vasomotor rhinitis. The patients who have history of stress and strain may also need Geriforte in addition to Septilin.

Adolescent↗
PubMed1985

Spectrum of renovascular hypertension in the young in north India: a hospital based study on occurrence and clinical features.

Occurrence of renovascular hypertension and its etiology is described in this work as seen in north India. Out of 2395 young hypertensives admitted for evaluation during the years 1978-1983, 91 patients (3.8%) were found to be having renovascular hypertension. In all patients suspected diagnosis of RVH was confirmed by the angiography of aorta and main vessels. Idiopathic aortoarteritis, diagnosed in 54 patients (59.4%) was the commonest cause of renovascular hypertension. In this group renal arterial involvement was found to be bilateral in 26 patients. Twenty-eight patients had isolated renal artery stenosis of unknown etiology. Six had fibromuscular dysplasia, 2 had polyarteritis and one had renal artery aneurysm. Twenty-three patients underwent surgery which included autotransplantation, arterial by-pass and nephrectomy with improved blood pressure control in 15. It is concluded that aortoarteritis seems to be the major cause of renovascular hypertension in the young in this part of the world.

Adolescent↗
PubMed1985

A double-blind crossover clinical trial of labetalol and propranolol in patients of essential hypertension.

The efficacy and safety of labetalol was compared in a double-blind crossover design with propranolol in 27 patients suffering from essential hypertension with a supine diastolic blood pressure of more than 100 mm Hg. Twelve patients completed the trial. Both the drugs significantly reduced the blood pressure as compared to pretreatment values and the end-point, i.e. a supine diastolic blood pressure of 90 mm Hg or less, was achieved at the end of each treatment. However, the control of blood pressure appeared to be better sustained with labetalol. The side-effects, though minor in nature, were relatively more often observed with propranolol.

Clinical Trials as Topic↗
PubMed1985

Fixed ratio combination of propranolol and bendrofluazide in the treatment of hypertension.

The combination of beta adrenoceptor blocker, i.e. propranolol (80 mg) and a diuretic, i.e. bendrofluazide (2.5 mg) in a single capsule (Inderetic) produced an effective control of blood pressure in 12 out of 13 patients with mild and moderately severe hypertension in this single-blind study. Treatment for 12 weeks did not produce any changes in biochemical parameters and no change in ECG, except that a significant decrease in heart rate was observed. No serious side-effects were observed.

Adult↗
PubMed1985

Double blind cross-over clinical trial of acebutolol and propranolol in angina pectoris.

Twenty-four patients with classical angina of effort completed this double-blind cross-over clinical trial of acebutolol and propranolol. Both acebutolol (100-400 mg) and propranolol (40-160 mg) three times a day produced a significant reduction in the incidence of anginal attacks, consumption of nitroglycerine tablets and increased exercise tolerance. Both drugs produced mild and tolerable side effects which did not require any reduction of doses of the drugs being used. No change in laboratory parameters assessing the function of the liver, the kidneys and the hemopoietic system was found. The commonly accepted dose ratio of 1:2.5 propranolol and acebutolol, respectively, was found to be true in less than 50% of the patients. Therefore, for optimal effect, the dose of acebutolol should be individualized depending upon the response.

Acebutolol↗
PubMed1985

Double-blind cross-over clinical trial of acebutolol and propranolol in mild to moderate essential hypertension.

Twenty patients with mild to moderate essential hypertension completed this double-blind cross-over randomized clinical trial of propranolol and acebutolol. Acebutolol was found to be as effective and safe as propranolol in lowering the systolic and diastolic blood pressure both in supine as well as in standing positions. However, the difference between the two drugs was not statistically significant. No significant change was produced in serum electrolytes, uric acid, fasting blood sugar with either drug. The accepted dose ratio of 1:2.5 propranolol and acebutolol, respectively, was found to be true only in 50% of the patients. Therefore, for optimal effect, the dose of acebutolol should be individualized depending upon the response.

Acebutolol↗