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B Jones

Publications and source records attributed to B Jones.

At least 757 records · Page 42Linked to original sources
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Pseudomembranous colitis: CT evaluation.

The CT findings in five patients with pseudomembranous colitis are presented. The findings consisted of varying degrees of bowel wall and haustral fold thickening. Ascites was noted in three patients. Clinically and radiologically, pseudomembranous colitis can be confused with other inflammatory disorders of the gastrointestinal tract. Although the CT findings were not pathognomonic, they were highly suggestive of pseudomembranous colitis when combined with the clinical information.

Adult↗
PubMedDate not supplied

Bladder involvement in Crohn disease: role of CT in detection and evaluation.

A retrospective review of 275 consecutive patients with symptomatic Crohn disease to determine the frequency and type of bladder involvement yielded 14 cases. All 14 patients had a long standing history of Crohn disease with other positive radiologic features at the time of detection of bladder involvement. Patients were categorized into two groups based on the CT findings: Group I (n = 4) had focal bladder wall thickening adjacent to an extravesical soft tissue mass and/or focal bowel wall thickening; Group II (n = 10) had fistula formation with intravesical air with associated focal bowel wall thickening and/or extravesical soft tissue mass. Bladder involvement in Crohn disease is a progressive pathological process that can result in formation of an enterovesical fistula. The patient may come to radiologic attention at any stage in the course of the disease. Computed tomography is a sensitive and noninvasive method of evaluating the bladder and can be used to identify patients in the prodromal stage who are at risk of developing enterovesical fistulae. Timely intervention may prevent frank perforation into the lumen of the bladder by an inflammatory mass.

Adult↗
PubMedDate not supplied

The accuracy of CT staging of small bowel adenocarcinoma: CT/pathologic correlation.

PURPOSE: Several studies have documented the use of CT in the evaluation of small bowel neoplasms, but few have addressed the CT staging of adenocarcinoma. We retrospectively correlated CT and pathologic staging to evaluate the accuracy of CT for staging small bowel adenocarcinoma using American Joint Committee on Cancer criteria. METHOD: The preoperative CT scans of 15 patients with pathologically proven small bowel adenocarcinoma were analyzed. Two blinded readers separately interpreted extent of invasion, presence of lymphadenopathy, and distant metastases. Pathologic and CT staging were compared. RESULTS: The overall accuracy of CT staging was 47% (14/30). The sensitivity of detection of mesenteric infiltration was 88%. The sensitivity and specificity for detection of distant metastases were 58 and 63% and for lymphadenopathy 75 and 20%, respectively. Errors occurred in patients with Crohn disease, adenomas, Peutz-Jegher syndrome, small bowel obstruction, and perforation and on suboptimal studies. CONCLUSION: The accuracy of CT staging of small bowel adenocarcinoma is 47%. CT is highly sensitive but not specific for the detection of mesenteric infiltration and regional lymphadenopathy. Since spiral CT may offer improved detection of distant metastases and increased accuracy in the evaluation of patients with concomitant bowel disease, further research is needed to determine the maximal utility of CT in the staging of adenocarcinoma of the small bowel.

Adenocarcinoma↗
PubMedDate not supplied

The CT halo sign: a new finding in intestinal lymphangiectasia.

A "halo sign" has been described in patients with Crohn disease, ulcerative colitis, radiation enteritis, ischemic colitis, and pseudomembranous colitis. This sign is characterized by an inner ring of low CT attenuation surrounded by a higher attenuation outer ring. We present a patient with primary intestinal lymphangiectasia in whom CT demonstrated a halo sign correlated with mucosal biopsy.

Adult↗
PubMedDate not supplied

The quality of life.

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Abortion, Legal↗
PubMedDate not supplied

Injury to the lateral ankle ligaments of athletes. A posttraumatic followup.

Twenty of 26 original athletes with injuries to the lateral ligaments of the ankle were reexamined 2 to 5 years following treatment. The functional quality of their anterior talofibular (TF) and calcaneofibular (CF) ligaments was tested by stress examination, using a commercially available stress device, and was compared with the results of stress examination, arthrography, and surgery at the time of injury. Surgically treated patients showed a 70% to 100% recovery of the functional properties of the lateral ankle ligaments on comparison with the contralateral, uninjured ankle. Of the six patients treated conservatively with elastic bandages and rest, only one had regained normal function, whereas the others showed minimal or no improvement. Isolated lesions of the anterior TF ligaments, when treated conservatively, may have only a slightly better prognosis than a combined lesion of both anterior TF and CF ligaments in the athletic population.

Adolescent↗
PubMedDate not supplied

Elevated 80K-H protein in breast cancer: a role for FGF-1 stimulation of 80K-H.

An increase in fibroblast growth factor-1 (FGF-1) is established as part of the cause of several important cancers including breast cancer, but the mechanisms by which it induces malignant behavior are not known. We now report that the protein 80K-H, a substrate for PKC, appears to be part of this mechanism and that it is increased in breast cancer and localizes to the nucleus as part of the mechanism. Our conclusion is based on an examination of a total of 58 biopsy specimens from human breast cancer patients for the presence of relationships between the 80K-H protein and the following: fibroblast growth factor receptor-1 (FGFR-1), tumor grade, microvessel counts (MVC), estrogen receptor (ER) and progesterone receptor (PgR) status. Based on histological grading and immunohistochemical (IHC) assays, we found strong direct relationships between 80K-H and FGFR-1 (r = 0.49, p = 0.003) and tumor grade (r = 0.42, p = 0.006). A trend for a direct relationship was observed with PgR (r=0.27, p=0.087). Notably, 80K-H immunostaining was largely limited to the epithelial cells of the mammary ducts. Subsequently, we studied the effects of FGF-1 on 80K-H in cultured human mammary carcinoma epithelial cells in order to establish a more direct relationship between these two molecules. We observed that FGF-1 treatment of MCF-7 cells stimulated translocation of 80K-H protein to the cell nucleus, as demonstrated by subcellular fractionation studies. Maximal intranuclear 80K-H was observed approximately 30 minutes following FGF-1 treatment. In addition, FGF-1 treatment of MCF-7 cells increased growth and invasion of MCF-7 cells, as demonstrated by cell proliferation and a modified Boyden chamber assay, respectively. Further support for 80K-H nuclearization was provided by the immunostaining of human breast cancer specimens and computer-assisted identification of a putative nuclear localization signal (NLS) near the amino terminus of 80K-H protein structure. These data support the existence of a previously unrecognized FGF-1/80K-H nuclear pathway in progression of human breast cancer and suggest that 80K-H may be useful for the assessment of breast tumor progression.

Active Transport, Cell Nucleus↗
PubMedDate not supplied

Immunoglobulin deficiency in Cavalier King Charles Spaniels with Pneumocystis pneumonia.

Serum concentrations of immunoglobulin G (IgG), IgM, and IgA were measured in 9 Cavalier King Charles Spaniels with pneumonia caused by Pneumocystis sp that were examined at 4 veterinary surgeries in the United Kingdom (UK) between September 2001 and November 2002. Pneumocystis pneumonia was confirmed in all dogs by visualization of the organism in bronchoalveolar lavage fluid or a transthoracic lung aspirate. Two dogs had a history of demodicosis. Immunoglobulin concentrations also were measured in breed-and age-matched dogs sampled over the same period. IgG concentrations were significantly (P = .000) lower in the affected dogs (median 3.2 mg/mL) than in the control dogs (median 8.5 mg/mL). IgM concentrations were significantly (P = .002) higher in the affected dogs (median 1.95 mg/mL) than in the control dogs (median 1.12 mg/mL). One affected dog had no change in IgG concentration more than 3 months after resolution of infection or vaccination, but did have reduction in IgM concentration after resolution of infection and vaccination. Control dogs had low serum IgG and IgM concentrations, compared with the reference interval for all dogs. Lymphocyte count in blood was normal or high in 7 of 8 affected dogs. The results of this study suggest that there is a defect in immunity in Cavalier King Charles Spaniels that underlies the susceptibility of these dogs to pneumocystosis. Further studies are indicated to elucidate the mechanisms behind the defect, the prevalence within the breed, and the potential mode of inheritance of the problem.

Animals↗
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Tenckhoff catheter salvage by closed stiff-wire manipulation without fluoroscopic control.

OBJECTIVE: To describe the results of Tenckhoff catheter salvage by a modified, closed, stiff-wire manipulation technique without the use of general anesthesia or fluoroscopy, and compare this with previously described techniques. DESIGN: Retrospective study in patients treated with continuous ambulatory peritoneal dialysis (CAPD) over a 41-month period. SETTING: Renal unit in an inner city hospital. PATIENTS: Eighteen patients using CAPD who had 22 episodes of outflow failure due to radiologically confirmed malposition of straight two-cuff Tenckhoff catheters. INTERVENTIONS: Closed stiff-wire manipulation of malpositioned Tenckhoff catheter without the use of general anesthesia or fluoroscopy. MAIN OUTCOME MEASURES: Initial success rate of manipulation, catheter and technique (CAPD) survival, and procedure-related complications. RESULTS: Catheter manipulation was technically successful in 21 of 22 cases. An additional six episodes of malposition occurred ranging from 2 to 630 days after the primary manipulation (median 7 days). A second manipulation was carried out in four cases that resulted in long-term success in two. Three patients were forced to discontinue CAPD for reasons other than catheter malposition, and the overall success rate at 1 month (patient successfully performing CAPD) was 59.1% (+/-0.1%). No major complications were experienced during the procedure and no episodes of peritonitis occurred. CONCLUSION: The technique described is relatively straightforward, does not require fluoroscopy or general anesthetic, and its success is comparable to previously reported methods of Tenckhoff catheter salvage. We would recommend this technique of catheter salvage in patients with Tenckhoff catheter malposition in whom conservative treatment has failed.

Adult↗
PubMedDate not supplied

Heart transplantation in females.

To confirm reports of a higher rate of rejection in female recipients of cardiac allografts and to determine whether infection rates and actuarial survival differ from that in males, we reviewed the results of 150 consecutive heart transplant procedures. Of these, 27 were in females and 123 were in males. Three different regimens were used over a 5-year period: group 1 (n = 37), cyclosporine and prednisolone; group 2 (n = 61), cyclosporine, azathioprine, and prednisolone; group 3 (n = 52), cyclosporine and azathioprine. All groups received a 7- to 10-day induction course with antithymocyte globulin. Female recipients had significantly more rejection episodes than male recipients to 3 months after transplantation (females 2.3 vs males 1.5 episodes/patient, p less than 0.01) and to 12 months (females 2.4 vs males 1.5 episodes/patient, p less than 0.02). These differences were largely caused by higher rates of rejection in females in both "double" therapy groups (groups 1 and 3). All surviving females in group 3 required the addition of maintenance steroids to control rejection. Gender mismatching of donors (male donor, female recipient) was identified as a factor associated with this requirement for conversion. Augmented treatment for rejection resulted in a higher rate of infection at 12 months in female recipients (females 1.5 vs males 0.7 episodes/patient, p less than 0.02), yet no female died of infection, and actuarial survival was comparable to that in male recipients. In view of the propensity of females to reject more frequently and earlier than males, triple therapy is currently the regimen of choice for female patients in the first 3 to 6 months after heart transplantation. Steroid withdrawal may be possible at a later time in those in whom this is indicated.

Actuarial Analysis↗
PubMedDate not supplied

Immunoglobulin deposition on soft contact lenses: relationship to hydrogel structure and mode of use and giant papillary conjunctivitis.

Since the IgG to IgA ratio in the tear film increases dramatically during inflammation, the ratio of immunoglobulins deposited on the soft contact lens surface should provide some indication of biocompatibility of the hydrogel. To study this premise, 60 soft contact lenses of low and high water content and ionic and non-ionic compositions were recovered after their useful lifespan from asymptomatic lens wearers and those experiencing active giant papillary conjunctivitis (GPC). Lenses were exhaustively extracted with saline to remove loosely bound immunoglobulins, dissected, and qualitatively assayed by means of chromogenic horse radish peroxidase-linked antibody probes for tightly bound IgG and IgA. The intensity of reaction was scored visually in a random, masked fashion by two independent observers using a standardized scale. The results reveal a consistent, although not statistically significant, increase in IgG to IgA deposition on the pathological lens population as compared to normals. This change may be reflective of an immune specific lens response and/or the enhanced titer of tear IgG resulting from the inflammatory process present with GPC. Deposition correlated more strikingly with two other linked parameters: hydrogel structure and mode of use. A marked increase in immunoglobulin deposition and enhanced IgG to IgA ratio (P less than 0.001) was common to high water content lenses (especially of non-ionic composition) used on an extended wear basis, when contrasted with low water content lenses used on a daily wear basis. It is thus hypothesized that use of high water content lenses on an extended wear basis leads to a greater degree of inflammatory and/or immune stress.

Biocompatible Materials↗
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Appetite for alcohol: influence of genetics and early experience.

Thirty male mice from three inbred strains (C57BL/10J, BALB/cJ, C3H/2Ibg) were assigned to infantile handling or control conditions. At sixty days of age, all animals were tested in a two-choice situation for selection of 10% ethanol vs. water. Consumption from both drinking tubes was recorded for 15 days and selection ratios for alcohol per total fluid volume were calculated. C57 mice demonstrated increased preference for alcohol as a result of early handling. The BALB strain, known for low preference for alcohol, showed increased preference for alcohol as well. C3H mice evinced a biphasic effect of early handling, showing an initially greater acceptance of alcohol as compared to controls, followed by decreased selection.

Alcohol Drinking↗
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Primary intestinal lymphangiectasia: clinical and CT findings.

We present two patients with biopsy proven primary intestinal lymphangiectasia in whom CT demonstrated diffuse nodular thickening of small bowel without adenopathy or hepatosplenomegaly. One patient had extensive ascites. Although the CT findings are not specific to lymphangiectasia, they may allow one to suggest the diagnosis in the patient with protein losing enteropathy and help distinguish it from inflammatory bowel disease, lymphoma, celiac disease, or Whipple disease.

Adult↗