Search PubMed⌕ Search

Biomedical subjects

B Jones

Publications and source records attributed to B Jones.

At least 649 records · Page 36Linked to original sources
PubMed1977

Allograft cytotoxicity. Two populations of effector cell detectable by cytolytic and cytostatic assays in vitro.

Using both the 51Cr-release assay to measure cytolysis and the [125I]UdR incorporation assay to detect cytostasis of target cells, two different effector populations have been identified in C57BL10 mice primed to P815Y cells. As expected, the cytolytic cells were T cells possessing a specific surface receptor. After elimination of T cells with specific antisera and complement the cytostatic effector was found to be an adherent cell which lacked an immunologically specific receptor, and exerted significant activity against the C57BL lymphoma, EL4.

Animals↗
PubMed1976

EEG and behavioral effects of delta9-tetrahydrocannabinol in combination with stimulant drugs in rabbits.

In rabbits, delta9-tetrahydrocannabinol (THC) at 0.5 mg/kg i.v., was challenged with i.v. methamphetamine (0.1 mg/kg), cocaine (1 mg/kg), apomorphine (1 mg/kg), or caffeine (12.5 mg/kg), and observations were made on quantified EEG and behavior. Cortical and hippocampal alterations produced by THC were antagonized by methamphetamine, cocaine, and caffeine and only briefly by apomorphine. Postural and activity behaviors were reversed by methamphetamine and caffeine but only briefly by cocaine and apomorphine. Additionally, stereotypy resulted from the combination of THC with methamphetamine, cocaine, or apomorphine. These data indicate that the effects of THC were antagonized by stimulant drugs of which caffeine was the most effective. However, novel toxicity also resulted from the interaction of THC with catecholaminergic drugs.

Animals↗
PubMed1976

Serum ferritin concentration in early breast cancer.

The concentration of circulating ferritin was measured in 250 normal adult women and 229 women presenting with early breast cancer. Ferritin concentrations are higher in cancer patients than in normal women. Patients with an intial circulating ferritin concentration above 200 mug/1 have a higher tumour recurrence rate during the subsequent 4 years.

Adolescent↗
PubMed1976

The perception of passive joint-movements by cerebral-palsied children.

Luce's choice theory provided the psychophysical basis for investigating the ability of cerebral-palsied children to detect passive movement of the elbow joint. The method included testing "yes" responses when the forearm was moved, and "false-alarm" responses of "yes" when no arm movement had occurred. The children were tested with their eyes closed. The results showed that, in general, the children with spastic cerebral palsy had no deficits, or only very minor ones, in passive movement sensation. In contrast, the athetoid children had considerable deficits. It is suggested that the athetoid child is affected by a continuous barrage of irrelevant proprioceptive information and so finds difficulty in discriminating any particular proprioceptive cue.

Cerebral Palsy↗
PubMed1976

Hypersensitivity pneumonitis after exposure to isocyanates.

Four patients exposed to isocyanate vapour developed dyspnoea associated with restriction and reduced gas transfer as well as moderate airways obstruction on lung function testing. In one patient bilateral radiographic shadowing was present and an open lung biopsy was performed. The microscopic appearances ranged from acute inflammation to end-stage fibrosis but the centribular accentuation of disease and the presence of areas resembling bronchopulmonary aspergillosis suggested that the process was a hypersensitivity response to inhaled allergen. Challenge tests with albumin and toluene diisocyanate-albumin were carried out in sensitized and control rabbits. The sensitized animals developed extensive lung damage of the type associated with an Arthus reaction. It is suggested that patients exposed to isocyanates may occasionally develop a hypersensitivity pneumonitis rather than the more usual asthmatic syndrome.

Animals↗