Search PubMed⌕ Search

Biomedical subjects

B Jones

Publications and source records attributed to B Jones.

At least 577 records · Page 32Linked to original sources
PubMed1982

Stroke: comparison of admissions in a community hospital.

A retrospective comparison was made of characteristics of stroke patients admitted to 3 distinct areas of the Union-Truesdale Hospital (renamed Charlton Memorial Hospital) in Fall River, MA. The Union Division has the option for admission to an acute care stroke unit or to the medical/surgical units. The Truesdale Division is separated by 1 mile and contains medical/surgical units. The Union Division also has a rehabilitation unit for post-acute care. The 2 divisions were separate corporations with generally separate medical staffs until a merger was effected in October, 1975. Using Professional Activity Studies (PAS) reports, a cohort of 418 patients discharged between October 1, 1975, and September 30, 1976, was developed. According to ICDA-8 coding, the 3 areas of the hospital had different profiles of patients. Outcomes in terms of types of discharges were also different between 4 categories of stroke pathology. Of 57 patients referred for rehabilitation, 43 had abrupt onset with persisting focal deficit (ICDA-8 codes 433/434/436), and 14 had less clear onset with diffuse neurologic loss (ICDA-8 codes 437/438). Of the patients referred for rehabilitation, 75% were returned home after an average of 16 acute hospital days and 23 rehabilitation hospital days. This study is on a small scale and may seem to have only local relevance, but the following estimates seem to offer a reasonable probability for planning rehabilitation facilities: approximately 25% of discharges with ICDA-8 codes of 433, 434, and 436; approximately 10% of discharges with ICDA-8 codes of 437 and 438; and approximately 2% of other stroke diagnoses. Average daily hospital charges were significantly less for patients cared for in the stroke unit.

Aged↗
PubMed1981

Deep venous thrombosis and a circulating anticoagulant in systemic lupus erythematosus.

We describe deep venous thrombosis and a circulating anticoagulant in a male adolescent with systemic lupus erythematosus (SLE). The association of deep vein thrombosis with SLE in a pediatric patient has not, to our knowledge, been previously reported. The circulating anticoagulant was characterized as a lupus-type inhibitor. This was demonstrated by an abnormal partial thromboplastin time (PTT), the failure of the PTT to correct with the addition of an equal amount of normal plasma, and a positive tissue thromboplastin inhibitor test. Physicians should be aware that a circulating anticoagulant can be associated with SLE and that there may be a paradoxically increased incidence of thromboembolic phenomena in patients with this abnormality.

Adolescent↗
PubMed1981

Agoraphobia: a situational analysis.

Examined previous notions about the nature of agoraphobia. A contrast of emphasis was found between those who regarded it primarily as a situational fear and others who saw it essentially as a product of some underlying anxiety. A more precise situational analysis was attempted that focused on six variables: Unaccompanied vs. with someone, distance from home, familiarity of location, crowdedness, type of location, and time spent. One hundred and twenty-eight situation descriptions were generated by factorially combining the different levels of each variable. The items thus produced were assembled randomly into a questionnaire that was completed by 30 agoraphobic patients. The importance of the contribution of each variable to the rated fear-provoking potential of the situation description was analyzed. Results were discussed in terms of the agoraphobic as typically dependent upon a significant other, and treatment implications were examined.

Adult↗
PubMed1981

Functional activities of antibodies against brain-associated T cell antigens. I. Induction of T cell proliferation.

Rabbit anti-mouse brain antiserum mediated an in vitro cooperative interaction between Ig-anti-Ig column-purified Lyt-1+, Lyt-2- T cells and spleen B cells. DNA synthesis in the B cells was inhibited with mitomycin C, and the T cell proliferative response was measured by [3H]thymidine incorporation after 24 h of culture. The T-B cell interaction was genetically unrestricted, and the accessory function of the B cell was engaged via interaction with the Fc portion of the T cell-bound anti-mouse brain antibody since the F(ab')2 fragment was inactive. The rabbit anti-mouse brain anti-serum appears to recognize a unique antigenic determinant in the T cell membrane which triggers proliferation. Although brain-absorbed, rabbit anti-mouse thymocyte antiserum contained antibodies which bound to the T cell surface, it was incapable of inducing T cell proliferation. Furthermore, the Thy-1 molecule itself did not appear to be involved because allo- and xenoantisera against the allelic determinants were inactive, and the capping of Thy-1.2 from the T cell surface did not prevent the binding of the mitogenic component in rabbit anti-mouse brain antiserum. The T cell reaction to anti-brain antiserum is unlike the antigen-specific T cell response in being genetically unrestricted. It is possible that the antibody operates via the perturbation of a T cell determinant involved in the binding of T cell growth factors, and/or reception of B cell feedback signals.

Animals↗
PubMed1981

Massive gas embolism in E. coli septicemia.

The case of an elderly women with radiographic evidence of gas within her portal vein as well as the iliac and femoral arteries is presented. The underlying cause proved to be E. coli septicemia. Differential diagnosis and clinical significance of intravascular gas are reviewed.

Aged↗
PubMed1981

The effect of heavy metal chelators on the renal accumulation of platinum after cis-dichlorodiammineplatinum II administration to the rat.

1 Rats received a total of 18 mg/kg cis-dichlorodiammineplatinum (II) (CDDP) intravenously and were treated concomitantly with calcium-disodium ethylenediaminetetraacetic acid (CaNa2EDTA), 2,3-dimercaptopropanol (BAL), deferoxamine, 2,3-dimercaptosuccinic acid (DMS) or vehicle. In comparison to controls, renal platinum concentration was significantly reduced in the DMS and deferoxamine-treated groups. However, significant deterioration occurred in the deferoxamine-treated group. The hepatic platinum concentration was unaffected by the chelating agents. 2 Following a dose of 6 mg/kg CDDP intravenously, eight days of treatment with DMS, 50 mg/kg daily, had no effect on renal platinum excretion, while treatment with 100 or 200 mg/kg daily reduced renal platinum concentration by 50%. 3 In order to determine whether DMS could prevent the nephrotoxicity of CDDP, rats were given 6 mg/kg CDDP intravenously, followed by a four day course of DMS treatment at doses of 0, 50, 100 or 200 mg/kg daily begun 3 h after the CDDP dose. DMS failed to prevent renal toxicity as indicated by weight loss, serum creatinine concentration, renal histology, and the urinary excretion of N-acetyl-beta-glucosaminidase, a renal tubular enzyme.

Acetylglucosaminidase↗
PubMed1980

Gallium-67-citrate scintigraphy in ulcerative colitis.

Gallium-67-citrate scanning was performed in 9 patients with ulcerative colitis. In all patients there was good correlation between the regional uptake of gallium and the extent and activity of disease. In 2 patients the scans were positive during an acute exacerbation and reverted to normal or near normal during clinical remission. In one patient in whom the colon was resected because of toxic dilatation, good correlation was found between pathologic and scintigraphic examinations. During the acute attack of ulcerative colitis, when colonoscopy or barium enema may be contraindicated, gallium scanning may be a noninvasive means of assessing the extent of colonic involvement. It may also be an alternative means of following the clinical course of the disease.

Adult↗