Search PubMed⌕ Search

Biomedical subjects

B Bergman

Publications and source records attributed to B Bergman.

At least 235 records · Page 13Linked to original sources

Serum antibodies against Escherichia coli and Proteus mirabilis after different types of operations.

The serum antibody titer against Escherichia coli and Proteus mirabilis before and after different types of operations was studied in 105 adult patients. The different operations were: pyelo- or ureterolithotomi (32); ileal conduit urinary diversion (20); cholecystectomi (34); operation in the thyroid area (10); operation of varicose veins of the legs (9); and colectomies (10). High serum antibody titers against E. coli were found in 16% of the patients preoperatively. Antibody titres against P. mirabilis were high in 19% of the patients with urinary tract calculus but in none of those without urological disease. The antibody titre against E. coli and/or P. mirabilis increased significantly more often after operation in the urinary tract or colon than after the other operations. Increase of antibody titers were more often seen in patients who preoperatively had normal titres. A normalization of the titers was seen during the following 12 months and in most of those patients within the first 3 months.

Adolescent↗

The distribution of nickel in mice. An autoradiographic study.

Metallic restorations are corroded in the oral environment. Corrosion products penetrate into the tissues and are distributed throughout the body seeking certain organs and tissues as targets. The distribution patterns of nickel in albino mice were studied autoradiographically at various periods after an intravenous injection of 63Ni in order to locate the target organs and tissues of nickel. With short survival periods the highest uptake of 63Ni was found in the blood, kidney, urinary bladder, lung, eye and hair follicles. With long survival periods, 3 weeks, the distribution pattern was dominated by high uptake in the lung tissues, central nervous system, kidneys, hard tissues and skin. The distribution pattern in brown mice was similar to that in albino mice. However, the concentration in the eye and the skin was more pronounced. The importance of release of nickel from nickel containing dental alloys in nickel allergic patients is discussed.

Animals↗

Tissue accumulation of nickel released due to electrochemical corrosion of non-precious dental casting alloys.

Specimens of four non-precious dental casting alloys intended for use in the ceramic-metal technique were implanted subcutaneously in the neck region of mice. The animals were killed after 5 months. Organs and tissues were tested as regards the concentration of nickel by means of atomic absorption spectrophotometry. The study showed that due to electrochemical corrosion nickel was released from implants and accumulated in some tissues and organs.

Animals↗

Pressure-volume relationship and fluid content in fetal rabbit lung after beta-receptor-stimulating drugs.

A considerable interest has been focused on the effects of various drugs on fetal and neonatal pulmonary maturation and adaptation. In the present study, we have investigated the effects of the selective beta1- and beta2-receptor-stimulating agents prenalterol and terbutalilne on the pressure-volume relationship and fluid content in fetal rabbit lung at 28 days of gestation. Pressure-volume recordings during deflation showed significantly increased lung volumes at equivalent transpulmonary pressures in terbutaline-treated fetuses as compared to controls. No such effect was noted after prenalterol. In the control animals, wet lung weight/body weight ratio decreased to a steady state level 60 min after birth, indicating a rapid dehydration of the lungs. This dehydration was present at delivery after terbutaline and prenalterol treatment. The amount of fluid collected from the airways was also reduced after terbutaline and prenalterol treatment. The present results indicate facilitated neonatal respiratory adaptation after especially terbutaline treatment. Possible mechanisms behind these effects are discussed.

Adrenergic beta-Agonists↗

Primary carcinoma of the Bartholin gland.

A report of a patient with a Bartholin gland cancer is presented. Although this desease is rare, it should be born in mind when treating common Bartholin gland enlargements. Bartholin gland carcinomas are misdiagnosed as common cysts or abscesses in half of the cases, leading to considerable delay in diagnosis. From a review of the literature concerning this disease some recommendations are made.

Adenocarcinoma↗

Respiratory depression by GABA-ergic drugs in the preterm rabbit.

Respiratory parameters were studied in preterm rabbits (gestational age 29 days) after intraperitoneal administration of the GABA-like drugs gamma-hydroxybutyric acid and muscimol. The animals were anaesthetized with 0.7% halothane in oxygen and studied in a closed body plethysmograph. Both drugs induced a decreased respiratory frequency and minute volume. Tidal volume decreased after muscimol, but not after gamma-hydroxybutyric acid administration. The present results indicate that an increased GABA-ergic activity causes respiratory depression in the preterm neonatal rabbit, presumably by an action on central nervous frequency and tidal volume modulating systems. Central GABA neurons may thus be involved in the pathogenesis of neonatal respiratory depression and irregular breathing.

Animals↗

Adrenal catecholamines during and following hypoxia in neonatal rats.

The synthesis and content of adrenal catecholamines during hypoxia (6% O2) and the following recovery period were investigated in 4-day old rats. Adrenal catecholamine synthesis, as indicated by the dopamine content of the glands, increased significantly during hypoxia. During hypoxia a significant decrease in the adrenal noradrenaline but not adrenaline content was noted. In the recovery period following 30 min of hypoxia the noradrenaline level was rapidly restored to the control value. The results show that hypoxia causes increased catecholamine synthesis in the immature rat adrenal gland, presumably mediated by an increased tyrosine hydroxylase activity induced via the splanchnic nerves. In the neonate rat hypoxia seems to stimulate the release of a larger proportion of noradrenaline than adrenaline from the adrenal glands when compared to the adult animal.

Adrenal Glands↗

The effect on erection and orgasm of cystectomy, prostatectomy and vesiculectomy for cancer of the bladder: a clinical and electromyographic study.

Forty-three men who had been subjected to cystectomy and concomitant prostatectomy, vesiculectomy and urethrectomy were interviewed about their pre-operative and post-operative sexual activities at a mean of 3 (range 1 to 8) years after operation. Twenty-eight of the 38 men (74%) who had been sexually active continued to have some form of sexual activity, 21 of them achieving orgasm. Only 3 men had penile erection; 2 of them had been subjected to prostatectomy and 1 to prostatic resection. One of these men treated by prostatectomy had also had urethrectomy. Electromyographic registration from the striated external urethral sphincter, the bulbocavernosus muscle and the levator ani muscle showed normal duration of muscular contractions and length of interval between contractions after operation. The pattern of impulses during organs did not differ from that of normal men.

Adult↗

Conduiturinary diversion and urinary-tract infection. I. Serum antibody titers against Escherichia coli and Proteus mirabilis in relation to urographic findings.

The serum antibody titers against Escherichia coli and/or Proteus mirabilis were elevated in 26 of 80 patients (33%) with a conduit urinary diversion. Urographic findings were abnormal in 44 of these 80 patients (55%). Urography was normal in 59% of the patients with normal antibody titers, but in only 15% of those with elevated titers. Raised antibody levels against E. coli O antigen (greater than 256 before and/or greater than 32 after mercaptoethanol treatment of serum) were associated with wide upper urinary tract or calculi more often than were normal E. coli antibody titers. Raised titers against P. mirabilis (greater than 256 before and/or greater than 32 after mercaptoethanol treatment of serum) were associated with scarring of the renal parenchyma more frequently than were normal titers. A statistically significant association was found between "small" kidney area and raised serum antibody titers against E. coli or P. mirabilis. The frequency of "small" kidney increased with the time lapse after urinary diversion. At 3 to 11 months postoperatively it was 29%, but among the patients with urinary diversion for more than five years the corresponding frequency was 82%. When at least one kidney was "small", the serum creatinine was higher than when both kidneys were of normal size. Patients with raised antibody titers tended also to have high serum creatinine (greater than or equal to 124 mumol/l) more often than those with normal titers (23 vs. 10%). These observations imply a connection between elevation of the antibody titers and destruction of the renal parenchyma in patients with conduit urinary diversion. They illustrate the value of antibody titration in the follow-up of patients with urinary diversion.

Adolescent↗

Conduit urinary diversion and urinary-tract infection. II. Raised serum antibody titers against Escherichia coli and Proteus mirabilis in relation to bacteriologic findings.

Elevated serum antibody titers against Escherichia coli and/or Proteus mirabilis were found in 35% of 89 patients with a conduit urinary diversion. Statistical analysis showed significant correlation between the titers and growth of E. coli or P. mirabilis in conduit urine. But 17 (24%) of 72 patients without E. coli in urine cultures had raised E. coli antibody titer. Only 3 (4%) of 68 patients without growth of P. mirabilis had raised P. mirabilis antibody titer. When the post-diversion observation period was more than five years, the frequency of antibody titer elevation was greater than in patients with shorter post-diversion follow-up. The volume of residual urine in the conduit showed statistically significant correlation with presence of bacteriuria and with the antibody titer level against P. mirabilis. Patients with high antibody titers tended to have high readings of serum creatinine. Antibiotic therapy reduced elevated E. coli and P. mirabilis antibody titers. Titration of antibodies to E. coli and P. mirabilis is recommended in the follow-up care of patients with conduit urinary diversion.

Adolescent↗

Chronic papillomatous dermatitis as a peristomal complication in conduit urinary diversion.

In 76 patients with conduit urinary diversion, the skin in the stomal area was studied with regard to complications. No such complications had occurred in 39 cases. Superficial erosive dermatitis was present or had been a transient episode in 27 cases. The immediate peristomal area was found in ten cases to show a different type of complication. This was characterized by hyperplastic, papillomatous skin lesions of a chronic nature. A rubber urinary collecting device for long-term use had been fitted in nine of the ten patients, and none of them had a protruding nipple stoma. The clinical, microbiologic and histologic features of these hyperplastic lesions are described and aetiologic factors are discussed. Change to another type of collecting device was followed within three to six weeks by healing of the lesions.

Adolescent↗

Renal infection after ileal conduit urinary diversion. An autopsy study.

Autopsy records from cases with urinary bladder carcinoma, consisting of patients operated upon with conduit urinary diversion and controls without diversion, were studied. We found macroscopical evidence of upper urinary tract infection (renal abscesses and/or pus-filled pelves/ureters and/or reddish mucosa in pelves/ureters) in 18 of 21 conduit cases without evidence of cancer at autopsy and in 14 of 50 control cases. The difference is statistically significant (p less than 0.0005). Abscesses were found more often in conduit cases (10/21) than in non-diverted cases (8/50) (p less than 0.01). The known connection between dilated ureters and/or pelves and urinary tract infection was demonstrated in non-diverted cases.

Adult↗