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Biomedical subjects

B Bergman

Publications and source records attributed to B Bergman.

At least 217 records · Page 12Linked to original sources
PubMed1983

Effects of external radiation therapy for cancer of the prostate on the serum concentrations of testosterone, follicle-stimulating hormone, luteinizing hormone and prolactin.

Testosterone, luteinizing hormone, follicle-stimulating hormone and prolactin were analyzed in serum from 31 patients with carcinoma of the prostate treated primarily with megavoltage radiation therapy. The total tumor dose varied between 58 and 71 gray (mean 63.5 gray). Absorbed doses to the testes were measured at approximately 1 to more than 10 gray. We investigated retrospectively 17 patients 3 to 60 months (mean 20 months) after therapy and found significantly lower serum testosterone concentrations and significantly higher luteinizing and follicle-stimulating hormone concentrations than in age-matched controls. Of the patients 14 were followed before and after radiation treatment. Testosterone concentrations were reduced significantly 1 week as well as 3 months after treatment but pre-treatment values were found on analysis 6 and 12 months after treatment. The values for luteinizing and follicle-stimulating hormones were significantly higher 3, 6 and 12 months after radiation treatment compared to pre-treatment values. The follicle-stimulating hormone value already increased after 1 week. The greatest observed testosterone alteration occurred 1 week after treatment in patients who received more than 10 gray over the gonads. The use of lead shields protecting the testes reduced the dose absorbed to the gonads by approximately 50 per cent.

Aged↗
PubMed1983

Testicular endocrine function after withdrawal of oestrogen treatment in patients with carcinoma of the prostate.

The serum concentration of testosterone, luteinising hormone (LH), follicle stimulating hormone (FSH) and prolactin were determined at different intervals after withdrawal of oestrogen treatment in patients with prostatic carcinoma. Oestrogen therapy had been stopped in all patients because of the side effects of oestrogens. There was a negative correlation (r = -0.64) between serum testosterone concentrations and the duration of oestrogen treatment in patients investigated for more than 6 months after withdrawal of hormones. However, the decrease in testosterone concentration seems to be time-dependent. Thus patients who were treated for less than 3 years had normal testosterone concentrations approximately 6 months after withdrawal of the oestrogen therapy. This group of patients had a positive correlation (r = 0.49) between serum testosterone concentration and time elapsed after cessation of therapy. In contrast, patients treated for more than 3 years retained low testosterone concentrations even after 6 months. The other hormones did not vary between the groups. It is concluded that patients with carcinoma of the prostate treated with oestrogens for more than 3 years have an impaired Leydig cell function which might be irreversible.

Aged↗
PubMed1983

Effect of terbutaline on lung mechanics and morphology in the preterm rabbit neonate.

Lung morphology, surface properties of fetal pulmonary fluid, and lung mechanics during spontaneous breathing were studied in preterm newborn rabbits after antenatal administration of terbutaline (0.1 mg). The histological evaluation of lung sections revealed increased amounts of granular eosinophilic and sudanophilic material in the terminal airspaces. The amount of fetal pulmonary fluid was decreased in terbutaline-treated animals; the fetal pulmonary fluid also showed improved surface properties, evaluated by the pulsating bubble technique. Increased dynamic lung compliance without altered air-way resistance was found in terbutaline-treated animals during the first 30 min after onset of breathing. This report demonstrates that terbutaline has an initial beneficial influence on the preterm neonatal lung, probably due to release of preformed surfactant into the alveolar spaces and to dehydration of the lung.

Animals↗
PubMed1983

Effects of GABA and some GABA analogues on respiratory regulation in the preterm rabbit.

Preterm neonatal rabbits (gestational age 29 days) were given GABA (750 mg/kg) or the GABA-like drugs muscimol (2 mg/kg) and GHBA (375 mg/kg) intraperitoneally. Basal respiration and the ventilatory response to 10% CO2 were studied, before and after drug administration, in a whole body plethysmograph during halothane anesthesia. The three drugs tested all caused a decrease in minute volume. The decrease in minute volume was mainly due to a decrease in tidal volume after GABA and muscimol, while GHBA reduced minute volume due to a decrease in respiratory frequency. A decrease in respiratory frequency was also seen after muscimol administration. Changes in the respiratory time intervals were seen after muscimol and GHBA both causing significant increases in expiratory and respiratory time. 'Inspiratory drive' and 'respiratory timing mechanisms' were evaluated by VT/TI and TI/TTOT, respectively. GABA and muscimol reduced both VT/TI and TI/TTOT while GHBA only reduced TI/TTOT. Addition of 10% CO2 to the inhalation gas caused an increase in tidal volume and minute volume during control conditions. This response to CO2 was abolished by GABA and GHBA treatment. Our findings demonstrate that GABA and GABA-like drugs cause respiratory depression in the preterm neonate. Central mechanisms are most likely involved in this response. These findings may be relevant to the irregular or apneic breathing sometimes seen in the preterm human infant.

Animals↗
PubMed1983

Release and uptake of cobalt from cobalt-chromium alloy implants.

Cobalt-chromium alloy implants were placed subcutaneously in the neck region of mice, and the animals were killed after 8 weeks. The cobalt concentration was high in the connective tissue of the capsule formed around 5 out of 10 cobalt-chromium implants. In nine other tissues analyzed no statistically significant increases in the cobalt concentration were detected. The surgical procedure and the carrying of an implant did not influence the weight increase of the animals during the period of the experiment.

Animals↗
PubMed1982

Caries, periodontal and prosthetic findings in patients with removable partial dentures: a ten-year longitudinal study.

A 10-year longitudinal study was carried out on 27 patients treated with RPDs. Before the prosthetic treatment all patients were given oral hygiene motivation and instruction as well as periodontal therapy where indicated. The aim was a high level of cooperation. The RPDs, most of which were lower bilateral distal-extension dentures, were carefully planned and designed. During the follow-up period the patients were examined at yearly intervals, at which time remotivation and reinstruction regarding oral hygiene was given, and scaling, operative restorations, and prosthetic and other treatment procedures were preformed as required. Patient cooperation was excellent, and no significant deterioration of the periodontal status of the remaining teeth was found. In addition, there was a low increase in the frequency of decayed and filled tooth surfaces during the decade. The dentures showed damage and several changes during the follow-up period, conditions that necessitated various corrective prosthetic procedures.

Adult↗
PubMed1982

Nickel allergy and nickel-containing dental alloys.

Test pieces from five cobalt-chromium casting alloys intended for use in removable partial dentures were attached to the skin of 10 women with known allergy to nickel. Patch tests were also performed with nickel and cobalt salts. Nine of the 10 women showed clear-cut or strong patch test reactions to the alloy with 7% nickel, one patient also to one of the other alloys (less than 1% nickel). In five patients with contact allergy reactions to both nickel and cobalt salts mild or marked responses to some of the other alloys were observed. Corresponding observations were made in three out of the five patients with contact allergy reactions to nickel salt but not cobalt salt.

Adult↗
PubMed1982

Effects of total and subcapsular orchidectomy on serum concentrations of testosterone and pituitary hormones in patients with carcinoma of the prostate.

22 men with carcinoma of the prostate were consecutively subjected to either total or subcapsular orchidectomy at random. Serum concentrations of testosterone, follicle-stimulating hormone, luteinizing hormone, prolactin, thyroid-stimulating hormone and testosterone-estrogen-binding globulin were followed. No differences were found between the two groups during the 6-month follow-up period. Orchidectomy reduced testosterone concentration in all cases and none responded to human chorionic gonadotrophin stimulation 6 months postoperatively. The concentrations of free and bound testosterone were calculated but did not vary between the two types of operation, which were considered equally efficient in reducing testosterone concentration. However, doubts about the completeness of the operation might possibly arise in cases with cancer progress and therefore we prefer total orchidectomy as the first choice, but perform subtotal orchidectomy on those men preferring this type of operation psychologically.

Aged↗
PubMed1982

Terbutaline and pulmonary surfactant release in the rabbit fetus.

The influence of terbutaline on content of phospholipids and their fatty acid composition in fetal lung wash and lung homogenates was studied in 28-day-old rabbit fetuses. To obtain both the fatty acid composition and the quantity of lecithin and sphingomyelin gas-liquid chromatography (GLC) was used, which gave a linear relationship when compared to standard solutions of the phospholipids. The amount of lecithin was significantly increased in the lung wash in terbutaline-treated fetuses compared to controls, while the sphingomyelin content was unchanged. In the lung homogenates no quantitative differences were noted between the two groups. The fatty acid composition of lecithin and sphingomyelin did not alter neither in lung wash nor in lung homogenate after terbutaline administration. The present results indicate that beta-mimetics mainly act by favouring the release of preformed surfactant and not by stimulating the synthetic capacity of type II cells in the alveolar lining layer.

Animals↗
PubMed1982

Masticatory efficiency of complete denture patients. A clinical examination of potential changes at the transition from old to new denture.

The masticatory efficiency was studied among 19 complete denture wearers with their old and new dentures. The test chewing material was gelatin hardened by formalin. A standardized preparation of the test chewing material and the sieve-system is described. The patients were tested on seven different occasions from the period with the old dentures until about 1.5 years after the insertion of the new dentures. The test pieces were chewed for ten seconds--a practice test--20 seconds and until ready to be swallowed. The chewed material was strained in a sieve-system and masticatory efficiency indices were calculated. The results revealed no statistical significant differences in masticatory efficiency between any of the seven testing occasions with the method used. Thus no significant difference was noticed when patients changed from old to new dentures or during the first 18 months after insertion of new dentures.

Adaptation, Physiological↗
PubMed1982

Appearance of surfaces of dental amalgam in contact with gold. An in vivo study.

90 combined gold-amalgam specimens of three dental gold alloys and two amalgams were placed subcutaneously, intraperitoneally and in the cheek pouches of 15 golden hamsters. The appearance of the amalgam surfaces after one week was evaluated using scanning electron microscopy and light microscopy. The results showed that among the implants there was an obvious difference between the conventional amalgam and the non-y2 amalgam specimens as regards accumulation of plaque, which was much more pronounced on the conventional amalgams. The cheek pouch specimens with conventional amalgams differed markedly from the corresponding implant specimens, showing very little plaque accumulation. Some possible explanations for these observations are discussed.

Animals↗
PubMed1982

Penile blood pressure in erectile impotence following cystectomy.

Penile systolic blood pressure and systolic and diastolic brachial blood pressure were measured in 17 men who had undergone cystectomy and prostatectomy for cancer of the bladder. After the operation, 13 patients reported erectile impotence, while 4 retained sexual potency. Comparisons were made with 7 healthy, potent controls. The systolic penile blood pressure was significantly lower and the systolic pressure gradient between brachial and penile pressure was significantly higher in the men with erectile impotence than in the potent men. Reduced penile blood pressure after such operations may arise from vascular trauma. A surgical technique that protects penile blood vessels may conceivably reduce the risk of erectile impotence following cystectomy.

Adult↗
PubMed1981

Transient apnea after an enkephalin analogue in the preterm rabbit.

FK 33-824, a potent enkephalin analogue was administered systemically, 0.5-5 mg/kg to preterm neonatal rabbits. A marked decrease in respiratory frequency as well as irregular breathing and apneic spells was recorded at 5 mg/kg. Tidal volume was not affected. The enkephalin-induced respiratory depression was restored immediately after naloxone (10 mg/kg). Bases on the results it may be speculated upon whether brain stem enkephalin neurons are involved in the pathogenesis of neonatal transient apnea and irregular breathing.

Animals↗