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Biomedical subjects

B Amor

Publications and source records attributed to B Amor.

At least 253 records · Page 14Linked to original sources
PubMed1983

[National survey on reactive arthritis by the French Society of Rheumatology].

In 1982, 3370 cases of inflammatory rheumatism were declared. The geographical analysis of the distribution of these cases (departmental and regional) suggests that their distribution is not homogeneous throughout the country, with a predominance of psoriatic arthritis in the Midi and the Pyrenees and a predominance of rheumatic pelvispondylitis in Aquitaine. Based on the number of cases declared, we can calculate the distribution of each type of inflammatory rheumatism by age and by sex and the incidence per million inhabitants in each age group. These figures are only indicative, as the data from some departments was incomplete. The calculation of a "criterion of frequency" attempts to equalize this bias. Reactive arthritis (352 cases) represents 10.4 p. cent of all cases of inflammatory rheumatism. This large series collected over one year confirms the clinical data already established. The responsible organisms, by order of frequency, were: Chlamydia trachomatis, Yersinia enterocolitica, Shigella, Y. pseudotuberculosis and Ureaplasma urealyticum. 50 p. cent of these cases of arthritis were classified as reactive on the basis of clinical findings and history and the bacteria was not isolated. The HLA-B27 antigen is present in 68 p. cent of the 302 cases in which it was tested.

Adolescent↗
PubMed1983

[Familial studies of reactive arthritis].

A survey conducted by the French Society of Rheumatology indicates that 10 p. cent of subjects with reactive arthritis have a family history. This family history can be divided into 3 equal groups of diseases : rheumatic pelvispondylitis, reactive and unclassified arthritis and psoriasis (3.5 p. cent for each condition). The B27 antigen is present in 67 p. cent of cases of reactive arthritis, which is significantly lower than the incidence in rheumatic pelvispondylitis. Informative family studies are presented which demonstrate their value as an in diagnosis, the roles of hereditary factors and the arguments for and against a predisposing gene close to but different from B27.

Adolescent↗
PubMed1983

[Lymphocytic arthritis. 54 cases, of which 25 appear to be idiopathic].

The authors studied rheumatological disorders possibly accounting for significant articular lymphocytosis (greater than or equal to 90 percent). A precise diagnosis was established in 29 of 54 cases: haemophilic arthritis (3 cases), villonodular synovitis (3 cases), tubercular arthritis (1 case), rubella (1 cases), aseptic arthritis of Osler's endocarditis (2 cases), necrosis of the inner condyl (1 case), Gougerot-Sjögren syndrome (1 case), classical rheumatoid polyarthritis (8 cases), probable (7 cases). The other 25 patients suffered from: polyarthritis (7 cases), oligoarthritis (1 case), biarthritis (8 cases) and monoarthritis (9 cases) of undetermined etiology. Besides articular lymphocytosis, clinical radiological and histological study of these patients indicates that this is a distinct rheumatological entity.

Adult↗
PubMed1983

[Bone and phosphoro-calcium metabolism in reflex sympathetic dystrophy].

A combined study organised by the French Society of Rheumatology was devoted to the investigation of bone and phosphoro-calcium metabolism in cases of reflex sympathetic dystrophy. The following observations were made: the usual phosphoro-calcium parameters are not altered, apart from a slight elevation of the urinary calcium in multifocal forms of the disease, during the 3rd and 4th months; the level of PTH, studied in 11 patients, was normal in each case; the examination of 8 bone biopsies, one performed in the 7th week and six others performed during the 3rd and 4th months of the disease, showed, initially, invasion of the spongy tissue by oedema, signs of marrow stress and bone stress, with a reduction in the number of osteoblasts, without any marked alteration of bone remodelling. At a later stage, the biopsy shows intense bone remodelling with hyperosteoclastosis and hyperosteoblastosis and the formation of irregular bone tissue which later becomes lamellar. Electron microscopic study of two biopsies revealed signs of acellular demineralisation with normal appearance of the osteoblasts and osteoclasts.

Bone and Bones↗
PubMed1983

[The joint in algodystrophy. Joint fluid, synovium, cartilage].

The joint fluid in cases of algodystrophy was studied in 17 samples. It is poor in cells (275/mm3 with a mean of 15% polymorphs). The protein level was studied 4 times and was equal to or greater than 40 g/l, i.e. double the normal value. A detailed histological examination of 33 biopsies of synovial tissue reveals a typical appearance of the synovium in algodystrophy, defined by 6 features, 2 negative and 4 positive: absence of hyperplasia of the synovial lining, absence of any real inflammatory cell infiltrate, presence of a marked hypervascularity, an oedema of the chorion, especially marked in the first weeks of the disease, hyperplasia of the walls of some arterioles, and fibrosis of the chorion which becomes more marked as the disease progresses and which is predominantly in the deeper layers. The authors recall that articular cartilage can show superficial alterations of structure with areas of fibrosis.

Biopsy↗
PubMed1982

[Lethal forms of connective tissue disease with antiribonucleoprotein antibodies (author's transl)].

Following Sharp's initial findings, the presence of antiribonucleoprotein antibodies in patients with connective tissue disease has long been considered as a sign of favourable prognosis. However, the long-term follow-up of such patients has revealed an increase in the number of severe or lethal cases. The authors report one lethal case and review 22 other published cases. Attention is drawn to the frequency of forms with onset in childhood and of scleroderma-like forms. Most deaths are due to pulmonary lesions, but the heart and kidneys may also be involved. Histological lesions of visceral vasculitis are extremely common.

Adolescent↗
PubMed1982

Tiopronin (N-[2-mercaptopropionyl] glycin) in rheumatoid arthritis.

Two controlled trials have demonstrated that tiopronin, a new sulfhydryl compound, is active as a slow-acting antirheumatic drug in rheumatoid arthritis. One trial compared 10 patients receiving placebos and 20 receiving tiopronin, 1 gm/day; the second compared two groups of 16 patients who received either placebos or tiopronin, 1.5 gm/day. In addition, 80 patients (56 from the 2 trials plus 24 other patients) were followed up for a long period. Dropout rate for intolerance or inefficacy was comparable to that fund with D-penicillamine. Secondary toxic reactions resembled those of other sulfhydryl compounds.

Adolescent↗
PubMed1982

[Controlled study of nifedipine in the treatment of Raynaud's phenomenon].

In each of the 16 patients included in our first study [6 idiopathic Raynaud's phenomenon (I), 4 associated with systemic lupus erythematosus (SLE) and 6 with progressive systemic sclerosis (PSS)] digital vasospasm could be reproduced by immersion of both hands in cold water (4 degree C). Each patient received in a double-blind manner and random order on two consecutive days, the calcium-channel blocking agent nifedipine (20 mg) and placebo. Nifedipine protection against vasospasm provoked by cold water (4 degrees C) was considered good or excellent in 14 of the 16 patients (p less than 0.001 versus placebo). In the second study, 30 patients [12 I, 10 PSS, 5 SLE and 3 rheumatoid arthritis (RA)] received in a double blind manner and random order, on two consecutive weeks, nifedipine (20 mg 3 time daily) and placebo. The improvement with nifedipine (in percentage of the decrease of the number of vasospastic attacks) was 90.95 in the 1 group, 78.63 SLE and RA and 64.02 in PSS (p less than 0.01). An open study during 3 months has confirmed the effectiveness of nifedipine (10 mg 3 times daily). The improvement was 88.92 in the 1 group, 76.33 in SLE and RA and 59.16 in PSS, 7 out of 30 patients stopped the treatment because of side effects (headache, flush, nausea, oedema of the ankles). Thus nifedipine appears to be extremely useful in the treatment of Raynaud's phenomenon.

Adult↗
PubMed1982

[Evolution of connective tissue diseases with anti-ribonucleoprotein antibodies (in 28 patients) (author's transl)].

Follow-up of 28 patients with connective tissue diseases with anti-RNP antibodies revealed that the disease had followed a benign course in 19 cases and a more severe course (including one fatal outcome) in 9 cases. Severe symptoms were mainly renal, neurological, psychic, and articular in nature. The association of anti-DNA antibodies and or low blood complement levels was confirmed as being of poor prognostic significance. Correlating the clinical picture with the severity of the cases demonstrated one case of the severe form in 8 minor connective tissue diseases (arthralgia, Raynaud's syndrome, swollen fingers), three severe forms (including one death) in 9 cases of mixed diseases, and 5 severe forms in the 11 patients with isolated connective tissue disease. Minor connective tissue syndromes retain an overall favourable prognosis, but they may become severe. The poor prognosis of the juvenile forms and those related to scleroderma also has to be emphasised.

Adolescent↗
PubMed1982

Adjuvant arthritis in rat during pregnancy and lactation.

We have studied, in the female rat, the influence of pregnancy, lactation and pseudo-pregnancy on adjuvant arthritis. Pregnancy has a suppressive effect on the arthritis all the more marked as arthritis onset occurs during the third part of pregnancy. Pseudo-pregnancy with or without decidualization of the uterus does not modify the arthritis course; thus the corpus luteum and the decidual tissue cannot account for the observed improvement. Lactation has a beneficial effect that lasts until weaning. Amount of estradiol which insured approximate serum level of pregnant rats improves the polyarthritis. In the same conditions, progesterone remains inactive. Suppression by estradiol is observed in ovariectomized and intact females. Thus, in the female rat, pregnancy, lactation and physiological doses of estradiol improve adjuvant arthritis.

Animals↗