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Biomedical subjects

B Amor

Publications and source records attributed to B Amor.

At least 235 records · Page 13Linked to original sources
PubMed1983

[Long-term study of 150 mg. Bi-Profenid in patients followed at the Department of Rheumatology of Cochin Hospital].

The effectiveness and tolerance of Bi-Profenid 150 mg (two tablets a day) was evaluated in 37 patients under long-term treatment by retrospective analysis of case records. Mean duration of therapy was 15.5 months. Over this period improvement in the usual surveillance criteria was recorded. In 6 patients the "therapeutic follow-up test" allowed to decrease dosage to one tablet a day. Conversely, attempts at discontinuing the drug were followed by recurrence of pain. Tolerance was evaluated as excellent in 89% of cases and the only recorded side-effects were gastrointestinal.

Adult↗
PubMed1983

[Algodystrophy and metabolic abnormalities].

The French Society of Rheumatology national study of reflex dystrophy revealed a serum glucose greater than 1.20 g/l in 9.09 p. cent of cases, a serum uric acid greater than 70 mg/l in 25 p. cent of men and greater than 60 mg/l in 14 p. cent of women. Serum cholesterol was normal in males, but higher than the mean + 2 sigma in 23 p. cent of females. Serum triglycerides were higher than m + 2 sigma in 55 p. cent of men and 56 p. cent of women. From a group of 80 patients, 54 (67.5 p. cent) had at least one of the three metabolic abnormalities and 49 (61.25 p. cent) were hypertriglyceridaemic. This hypertriglyceridaemia is the most frequent abnormality found. When hyperglycaemia or hyperuricaemia are present it is almost always in association with hypertriglyceridaemia. Hypertriglyceridaemia is more common in algoneurodystrophy of the lower limbs (54/78, 69 p. cent) than in algoneurodystrophy of the upper limbs (5/22, 22.7 p. cent). Algoneurodystrophy is more often primary, when it occurs in the lower limbs and post-traumatic when it occurs in the upper limbs. A prospective study comparing several parameters of lipid metabolism in 24 patients with algoneurodystrophy and 15 matched controls showed a significant drop in the HDL Chol/HDL P1 ratio and in the DHL - HDL Chol/TG ratio in patients with algoneurodystrophy. Serum insulin was comparable in the 2 groups. Lecithin cholesterol acyl transferase (LCAT), SGOT, SGPT and GGT were normal. The essential role of hypertriglyceridaemia in the genesis of the characteristic bony lesions of algoneurodystrophy is discussed.

Adolescent↗
PubMed1983

[Diagnostic value of ultrastructural study of the synovial membrane in rheumatic diseases].

This paper deals with diagnosis value of synovium electron microscopic study in inflammatory and metabolic rheumatism. Detection in synovium of hydroxyapatite, Ca pyrophosphate and other biological crystals often need the use of EM. It is also a good diagnosis tool in inherited lipid and glucid metabolism disorders and to establish an anatomic correlation between the osteo-articular localization and the systemic disease. Furthermore EM is able to detect stigmata of previous treatment such as chrysotherapy, immune complexes deposits in tissues, amyloidosis fibrils and even viral or bacterial material.

Diagnosis, Differential↗
PubMed1983

[Role of calcitonin in pregnant rats : interaction with 1,25-dihydroxycholecalciferol on fetal bone resorption in vivo/in vitro].

We studied in pregnant Rat the effect of 1,25-dihydroxycholecalciferol (1,25(OH)2D3) alone or associated with calcitonin on fetal bone resorption measured by organ culture. 1,25(OH)2D3 (0.1 microgram per day) reduced fetal weight and increased fetal bone resorption. Calcitonin (30 mU/hr.) alone had no significant effects but, associated with 1,25(OH)2D3, it protected mother and foetus against the effect of the vitamin D3 metabolite.

Animals↗
PubMed1983

Calcium entry blocking agents in digital vasospasm (Raynaud's phenomenon).

We have evaluated the therapeutic effect of the calcium entry blocking agent nifedipine in Raynaud's phenomenon associated with connective tissue diseases and in idiopathic digital vasospasm. In a preliminary study 16 patients with a digital vasospasm that could be induced by hand-immersion in cold water (4 degrees C) were challenged a second time with cold water 1 and 6h after 20 mg oral nifedipine. Nifedipine provided an effective protection against this cold-induced vasospasm in 14 of the 16 patients. Thirty patients were included in a short-term ambulatory study: Raynaud's phenomenon was associated with progressive systemic sclerosis (PSS) in 10 patients, systemic lupus erythematosus (SLE) in five and rheumatoid arthritis (RA) in three; it was idiopathic (I) in 12 patients. Each patient received, in a double-blind manner and random order, on two consecutive weeks, nifedipine (20 mg three times daily) and placebo. Nifedipine proved to be effective: the mean number of digital vasospastic attacks per week decreased from 27.3 to 5.8 (P less than 0.01). The results in the SLE and RA groups were similar and were pooled. The improvement (in % decrease) was better in the idiopathic group (90.9) than in the SLE and RA group (78.6, P less than 0.02) and the PSS group (64.0, P less than 0.01).

Adult↗
PubMed1983

Chlamydia and Reiter's syndrome.

The role of Chlamydia trachomatis in Reiter's syndrome (RS) is reviewed. Chlamydia is an obligate, intracellular parasite which can be isolated from urethral smears in 36% of patients with RS. Two separate surveys carried out on RS patients in France, in 1977-78 and in 1982-83 showed that antibodies to C. trachomatis could be detected by a microimmunofluorescence test in 55% and 64% of subjects, respectively, and this is significantly higher than the levels found in rheumatoid or healthy controls. Further studies are indicated to evaluate the role of Chlamydia in RS.

Animals↗
PubMed1983

Effect of calcitonin in pregnant rats on bone resorption in fetuses.

Fetal bone resorption was measured by an organ culture technique using fetuses from intact or thyroparathyroidectomized pregnant rats. These experiments were performed to investigate the effects of 1,25-dihydroxycholecalciferol (1,25-DHCC) and salmon calcitonin (SCT) in pregnant rats, on both fetal growth and fetal bone resorption. Pregnant rats were given 0.1-0.5 microgram 1,25-DHCC per day from day 17 of gestation: in intact rats bone resorption was increased and fetal growth decreased; 1,25-DHCC probably modified fetal bone resorption in the absence of fetal parathyroid secretion. Infusion of SCT in minipumps (30 mu./h) did not modify plasma calcium levels in either the mother or fetuses, neither was bone resorption altered. In 1,25-DHCC-treated rats, SCT infusion resulted in an increase in fetal weight and a decrease in fetal bone resorption. On the other hand, SCT infusion was found to facilitate phosphate accumulation in fetuses. At the end of the SCT infusion the SCT concentration was 450 ng/l in maternal plasma and 553 +/- 60 ng/l in fetal plasma. Salmon calcitonin was shown to cross the placental barrier in the rats; it may interact with the effects of 1,25-DHCC in the fetus.

Animals↗
PubMed1983

[Treatment of algodystrophy. A randomized study of 95 cases with 3 treatments: Calsyn 100, Visken, Grisefuline and Penthonium].

Three randomised therapeutic protocols were studied: thyrocalcitonin, beta-blockers and the combination of Grisefuline + Penthonium, in a group of 95 cases of algodystrophy (64 women, 31 men). These cases were divided into four groups: upper limb, lower limb, "recent" or "long-standing". The results were assessed after one month of treatment. A positive result was defined as being an improvement of more than 50 p. cent of the clinical subjective and objective criteria; less than that, the activity is uncertain or nil. Comparison of the results did not reveal any statistically significant difference between the three proposed treatments, whether we consider the whole group of patients or each sub-group separately (overall positive results: Calsyn 100 = 53 p. cent, Visken = 42,5 p. cent, Grisefuline + Penthonium = 53 p. cent). The important role played by rehabilitation must be stressed. It should be discontinued during the acute phase and instituted in the later phase. Cure is obtained after an average of 4-5 months of treatment. 10 patients were left with major trophic sequelae after 2 years of the disease; all involve the hand.

Adrenergic beta-Antagonists↗
PubMed1983

[Role of membrane sialic acid of human granulocytes in the stimulation of NADPH,H+ oxidase activity].

The treatment of human polymorphonuclear cells by neuraminidase "type-X" removes about 15% of cell sialic acid without modifications of NADPH oxidase activity of granulocytes before and after stimulation by opsonized zymosan. A mild periodate treatment oxidizes only the poly-hydroxilic chain of sialic acid with formation of aldehyde groups. This treatment increases cellular NADPH oxidase activity and also largely prevents the stimulation of polymorphonuclear cells by opsonized zymosan.

Cell Membrane↗
PubMed1983

[Eosinophilic arthritis and general review of the significance of articular eosinophilia].

The authors report two cases of eosinophilic arthritis in allergic patients, which constitute the 9th and 10th reported cases. This condition consists of episodes of mildly painful, mildly incapacitating monoarthritis, essentially involving the knee, which last 2 to 15 days. These monoarthritis occur in young allergic patients; there are no allergic manifestations during the episode of arthritis and there is apparently no provoking allergen, but examination reveals intense dermographism. Apart from the presence of eosinophil polymorphonuclear cells in the synovial fluid, one can also find Charcot-Leyden crystals (one of the two cases in this study). The histological examination of the synovial membrane in one of these patients revealed an infiltration of eosinophil polymorphs. A raised serum IgE is always found. Including these two cases, the authors have found 11 out of 4277 specimens of joint fluid which show articular eosinophilia. The nine other cases consisted of one haemarthrosis, two post-arthrographic effusions, one filarial arthritis, one psoriatic rheumatism, one Gougerot-Sjögren syndrome and three cases of unclassifiable arthritis. Data from the literature show that articular eosinophilia is a rare phenomenon, that it does not constitute a simple local reflection of a blood hypereosinophilia and that it can consist of the cases found in this study.

Adolescent↗