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Biomedical subjects

B Amor

Publications and source records attributed to B Amor.

At least 271 records · Page 15Linked to original sources
PubMed1982

[Algodystrophy and metabolic anomalies].

The French Society of Rheumatology national study of reflex dystrophy revealed a serum glucose greater than 1.20 g/l in 9.09 p. cent of case, a serum uric acid greater than 70 mg/l in 25 p. cent of men and greater than 60 mg/l in 14 p. cent of women. Serum cholesterol was normal in male cases, but higher than the mean + 2 sigma in 23 p. cent of female cases. Serum triglycerides was higher than m + 2 sigma in 55 p. cent of men and 56 p. cent of women. From a group of 80 patients, 54 (67.5 p. cent) had at least one of the three metabolic abnormalities and 49 (61.25 p. cent) were hypertriglyceridaemic. This hypertriglyceridaemia is the most frequent abnormality found. When hyperglycaemia or hyperuricaemia are present it is almost always in association with hypertriglyceridaemia. Hypertriglyceridaemia is more common in algoneurodystrophy of the lower limbs (54/78, 69 p. cent) than in algoneurodystrophy of the upper limbs (5/22, 22.7 p. cent). Algoneurodystrophy is more often primary, when it occurs in the lower limbs and post-traumatic when it occurs in the upper limbs. A prospective study comparing several parameters of lipid metabolism between 24 patients with algoneurodystrophy and 15 matched controls showed a significant drop in the HDL Chol/HDL P1 ratio and in the DHL--HDL Chol/TG ratio in patients with algoneurodystrophy. Serum insulin was comparable in the 2 groups. Lecithin cholesterol acyl transferase (LCAT), SGOT, SGPT and GGT were normal. The essential role of hypertriglyceridaemia in the genesis of the characteristic bony lesions of algoneurodystrophy is discussed.

Adult↗
PubMed1982

[Destructive arthritis and Behçet's syndrome].

The arthritis of Behçet's syndrome is not usually responsible for articular destructions, so that the presence of destructive lesions makes the diagnosis of Behçet's syndrome doubtful. Here is presented the observation of a 29 years old man (his illness beginning at twelve), with a typical Behçet's syndrome, who developed a destructive arthritis. Arthritic and systemic flares showed a parallel evolution. Destructive lesions involved wrists, hands, feet and elbows. The search for another cause of destructive arthritis (mainly juvenile rheumatoid arthritis and ankylosing spondylitis) was negative. The occurrence of destructive arthropathies in Behçet's syndrome has been exceptionally reported.

Adolescent↗
PubMed1981

[Hydroxyapatite microcrystals in synovial mitochondria in human and experimental rheumatism].

This paper deals with mitochondria microcrystal deposition in some human inflammatory rheumatism and in experimental arthritis. Hydroxyapatite microcrystals were observed in Ankylosing Spondylitis (AS) and Reiter Syndrome (RS) but never in rheumatoid synovitis nor in chondrocalcinosis synovitis. In Rat and Rabbit experimental arthritis, they were always seen in mitochondria as in AS and RS and never in lysosomes. This fact suggests mitochondrial abnormalities in calcium metabolism, which may be a consequence of synovial inflammation in a susceptible host.

Animals↗
PubMed1981

Effectiveness of levamisole in rheumatoid arthritis: Immune changes and long-term results.

After a double-blind trial of 4 months, 40 patients with RA were treated with 100 mg Levamisole. Clinical results were good or excellent in 50%. The immunological status is not a valuable criterion for the selection of patients apt to respond to Levamisole. A good correlation was found between clinical improvement, reduction of ESR, percentage of immunoblasts, rheumatoid factor titre and the enhancement of lymphoblastic response to polyclonal mitogens. The treatment maintenance rate for efficacy was much lower for Levamisole than for D-penicillamine.

Adult↗
PubMed1981

[Narrow lumbar canal syndrome. Symptomatology and evolutionary aspects].

The authors report a retrospective study of 77 patients with a narrow lumbar canal syndrome (NLC). They recall the semiology, and the clinical and radiological findings which permit one to make the diagnosis and discuss, with an average follow-up of two years, the results of medical treatment (42 cases) or surgical treatment (35 cases), and the management which should be adopted. Medical treatment appears to be indicated in the mild forms of NLC, 34% of patients in this series (functional symptoms reduced and normal neurological examination at rest and after effort) where one may observe 80% of good results. Similarly, medical treatment should be attempted in certain more severe symptomatic forms where are still obtained 26% of good results permitting one to await surgery, and then reserve surgical treatment for failures or relapses. Operation is however definitely indicated in the forms where there are marked neurological signs. Under these conditions, the results of surgery and medical treatment seem comparable and one may note on the whole 60% of good results.

Adult↗
PubMed1981

[Follow-up study of patients with rheumatoid arthritis over a period of more than 10 years (1966-1978): analysis of disease progression and treatment in 100 cases (author's transl)].

A follow-up study was conducted in 100 rheumatoid arthritis patients, treated over the last 10 years with currently accepted therapy, after a period varying from 10 to 15 years following the onset of the disease: 20 p. cent were in Steinbrocker's stage I, 60 p. cent in stage II, 16 p. cent in stage III, and 4 p. cent in stage IV. When compared with a similar study conducted between 1948 and 1958, results demonstrated that the percentage of patients in stage I had not varied, but that only half as many patients were disabled (stages III and IV), due to insertion of lower limb surgical prostheses. Corticoid therapy had been necessary in 84 p. cent of the patients for variable periods. The 50 p. cent duration of the different treatments proposed during this 10-year period was 12 months for antimalarial drugs, 8 months for gold salts, and 12 months for D-penicillamine. Therapy was still effective after one year in 30 p. cent on antimalarial drugs, 27 p. cent on gold salts, 51 p. cent on D-penicillamine, and 21 p. cent on chlorambucil. Duration of efficacy of basic treatments is too short to cover the long progression of rheumatoid arthritis. New treatments are necessary, as the functional prognosis of this disease has not changed fundamentally over the last 15 years.

Adrenal Cortex Hormones↗
PubMed1981

[Spinal osteonecrosis in adults. Apropos of 4 cases].

The authors report on 4 cases of aseptic osteonecrosis of the vertebral matter in adult. The relatively rare localisation is the lot of elderly patients. It may follow cobalt therapy or corticotherapy and seems to be brought about by osteoporosis, hypertriglyceridemia and, perhaps, malignant lymphoidal proliferation. Histological confirmation of osteonecrosis was available in one case. The radiological aspect is characterised by settling, with heterogenic osteo-condensation and gaseous dissection of the vertebral matter. A double vertebral localisation is possible, and scintigraphical hyperfixation is common. The course is slowly favourable, with a symptomatic treatment.

Adrenal Cortex Hormones↗
PubMed1980

[Tiopronine, new anti-rheumatic drug, has slow action in rheumatoid arthritis].

2 mercapto propionyl glycine (tiopronine) has, like D-penicillamine, a thiol radicle; it is a powerful chelating agent of heavy metals. This analogy suggests that it may be used in rheumatoid arthritis. A preliminary double blind study lasting four months comparing 1g./day in 20 patients and a placebo in 10 patients showed slight (non significant) efficacy concerning all parameters. An open study using 1.5 g. daily is being carried out in 32 patients, and we note a beneficial effect on the morning stiffness, the joint index, the functional index, the prehension strength, the E.S.R., and the joint swelling. The side effects are similar to those of D-penicillamine: loss of taste, proteinuria, mucous ulceration, which required stopping treatment. The therapeutic effect within 4 months and was maintained for 18 months in the 15 patients under treatment. A new double blind trial comparing placebo and tiopronine at a dose of 1.5 g. daily is in progress.

Amino Acids, Sulfur↗