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Biomedical subjects

A Singh

Publications and source records attributed to A Singh.

At least 811 records · Page 45Linked to original sources

Radionuclide assessment of peritoneo-venous shunt patency.

LeVeen shunt patency can be easily assessed by sequential scintigraphy with a gamma camera after an intraperitoneal injection of Tc-99m-macroaggregated albumin (Tc-99m-MAA). If the shunt is patent, the particles of MAA reach the pulmonary capillary bed and the lungs are visualized. The activity in the lungs is easily discerned without any interference from radioactivity in the peritoneal cavity. The study is semiquantitative since the intensity of lung activity is directly proportional to the shunt patency and flow rate across shunt tubing.

Ascites↗

Transmission computed tomographic diagnosis of experimentally produced acute pulmonary vascular occlusion in the dog.

Acute experimental pulmonary arterial occlusions were produced in 5 dogs. The chest was subsequently imaged with computed tomography (CT), 99mTc-MAA scintigraphy, and plain radiography. Gamma images revealed all 6 lesions, and plain radiographs were uniformly negative. Enhanced CT scans demonstrated 3 of 5 lesions, and unenhanced scans revealed 1 of 6. CT findings were variable.

Animals↗

Transmission computed tomography, Tc-99m MAA scintigraphy, and plain chest radiography after experimentally produced acute pulmonary arterial occulusion in the dog.

We have occluded segmental and subsegmental pulmonary arteries in the dog with Swan-Ganz balloon catheters or i.v. injection of autologous clot, and have studied the chest with transmission computed tomography (TCT), Tc-99m-MAA gamma imaging, and plain radiographs. The arterial occlusions were between 1 and 5 hr old at the time of imaging. Radiographs revealed no lesions. Tc-99m MAA scanns revealed ten of 11 lesions. When a TCT image was made before i.v. injection of Renografin-60, two of 11 lesions were identified; after Renografin the score was four out of ten. The appearance of lesions on TCT was highly variable. Tc-99m-MAA gamma imaging, therefore, is far more accurate than TCT in the identification of small experimentally produced acute pulmonary arterial occlusions in the dog, and our study fails to suggest a secure place for TCT in the diagnosis of small, acute human pulmonary emboli. The commonly-held assumption that postembolic lung is oligemic is questioned.

Animals↗

Polyarthritis and bone lesions complicating traumatic pancreatitis in two children.

The association of bone lesions, polyarthritis and cutaneous nodules with pancreatic disease is being recognized and reported more frequently. In adults all forms of pancreatitis and carcinoma of the pancreas have been involved, but in the few children described these complications have been associated with acute traumatic pancreatitis. This paper describes two cases of acute traumatic pancreatitis in which polyarthritis and limb pains were noted after 2 to 3 weeks. In one child osteolytic lesions and periostitis were seen on roentgenograms 7 weeks after the onset of pancreatitis. In the other child minor roentgenographic changes were not seen until 5 months after the onset; however, bone scans showed clear-cut abnormalities after 1 month. Almost complete resolution could be expected within a year. Serum lipase and amylase concentrations remained elevated during the acute illness. Disseminated fat necrosis is apparently related to the excess amounts of circulating lipase.

Acute Disease↗