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Biomedical subjects

A Sano

Publications and source records attributed to A Sano.

At least 253 records · Page 14Linked to original sources
PubMed1980

Inhibitory and stimulatory effects of guanyl-5'-yl imidodiphosphate on the adenylate cyclase activity of rat synaptosomal fractions.

Guanyl-5'-yl imidodiphosphate (Gpp(NH)p), a nucleotide phosphohydrolase-resistant analog of GTP, caused inhibitory and stimulatory effects on the basal adenylate cyclase activity of rat synaptosomal fractions when manganese was present in the assay mixture, whereas the nucleotide caused only a stimulatory effect when magnesium was employed. In the presence of manganese, the inhibitory and stimulatory effects of Gpp(NH)p could be seen at around concentrations of 10(-7) M and 10(-4) M Gpp(NH)p, respectively. The inhibitory and stimulatory effects of Gpp(NH)p were both antagonized competitively by GTP; these effects of the analog were the opposite of those observed with GTP, which was stimulatory and inhibitory for fat call adenylate cyclase at 10(-7) M and 10(-4) M, respectively (Yamamura, H., Lad, P.M., and Rodbell, M. (1977) J. Biol. Chem. 252, 7964--7966). The degree of inhibition by Gpp(NH)p did not depend on the concentration of manganese nor on the addition of ethylene glycol bis(beta-aminoethyl ether)-N, N, N', N'-tetraacetic acid.

Adenylyl Cyclases↗
PubMed1980

Multiplicity of phosphate acceptor proteins for muscle glycogen phosphorylase kinase.

Although muscle glycogen phosphorylase kinase reacts preferentially with an inactive form of phosphorylase, the enzyme is able to phosphorylate in vitro multiple species of unidentified endogenous proteins in mammalian tissues such as liver. The reactions absolutely require Ca2+. Phosphate acceptor proteins are most abundant in the soluble and microsomal fractions. Sodium lauryl sulfate-slab gel electrophoresis analysis has revealed that the spectrum of phosphate acceptor proteins entirely differs from that for cyclic AMP-dependent protein kinase, although the biological significance of these reactions is unclear. Nevertheless, it is suggested that the enzyme is potentially multifunctional and plays roles in controlling some of the Ca2+-dependent processes. In contrast, myosin light chain kinase which is another species of calmodulin-dependent protein kinase seems to be strictly specific for this particular protein, and does not utilize any other endogenous protein so far tested.

Animals↗
PubMed1978

Surgical treatment of thoracic aneurysm in a hemodialysis-dependent patient: a case report.

A 53-year-old woman who was on hemodialysis underwent the resection of an aneurysm of the descending thoracic aorta as well as graft replacement. The operation was performed with the aid of femoro-femoral bypass perfusion and an artificial kidney inserted on the venous side of bypass line. Although the perfusion time was short, the uremic metabolic substance was efficiently removed, resulting in easy management after surgery.

Aorta, Thoracic↗
PubMed1976

Ruptured aneurysm of aortic sinus of Valsalva into right atrium. Associated atrioventricular block presumable caused by aneurysmal compression of His bundle.

We have seen a case of rupture of an aneurysm of the noncoronary sinus into the right atrium. Surgery revealed an aneurysmal mass the size of the tip of an index finger extending through the inter-atrial septum down to just above the tricuspid valvular ostium. An electrocardiogram showed first-degree atrioventricular block, while the His bundle electrogram demonstrated the presence of disturbances in the intra-atrial as well as His bundle conduction. The disturbance in His bundle conduction was interpreted as being due to compression of the His bundle by the aneurysm.

Adult↗
PubMed1976

Anomalous origin of left coronary artery from pulmonary artery.

An anomalous origin of the left coronary artery from the pulmonary artery in a 26-year-old man was corrected by the ligation of the artery at its anomalous origin, followed by the construction of an aortocoronary bypass with a venous graft. The flow of blood to the myocardium was measured for the purpose of comparing the effect of the bypass method with that of the ligation method. The result suggested that the bypass method provided a greater flow of blood to the myocardium than did ligation alone.

Adult↗