Biomedical subjects

A Sabbah

Publications and source records attributed to A Sabbah.

At least 145 records · Page 8Linked to original sources

PubMed1989

[Significance of anti-gluten IgA levels for detection and monitoring of celiac disease].

Diagnosis of coeliac disease rests in jejunal biopsy. This is recognised as a traumatic examination which today may perhaps be replaced by a biological test produced by Pharmacia in which the anti-gluten IgA is measured by the ELISA method. The sensitivity of the test reaches 100% and the specificity to 96%. This biological test makes it possible to follow the development of the coeliac illness under diet, since the anti-gluten IgA diminishes significantly, often to the normal level.

Adult↗

PubMed1989

[Role of food allergy in atopic dermatitis].

Food allergy is one of the main causes of atopic dermatitis. Its frequency was established at 41.3% in our study. Eggs, cows milk and wheat were the foods most often responsible for DA. Proof by elimination-reintroduction is the best diagnostic criterion in food allergy, leading to suppression of the food if its nutritional importance permits this. This food suppression leads to 84% clinical improvement of DA.

Adolescent↗

PubMed1989

[Hereditary angioedema].

Hereditary angio-oedema (AOH) is a familial affliction that is most often hereditary, but sometimes acquired and linked to a deficiency of C1 esterase inhibitor. 8 cases have been examined, amongst which there was one attack in a young girl, without any clinical signs. Amongst the other 7, one had acquired AOH. The diagnosis was confirmed by the deficiency of C1 esterase inhibitor, associated with a significant reduction of the other fraction of complement c3-c4 and also total haemolytic complement. Strong doses of corticosteroids were used in 4 patients for urgent treatment. Basic treatment with DANAZOL was commenced in 3 patients.

Adolescent↗

PubMed1988

[The human basophil degranulation test. Attempt at determining its reliability].

A single-blind assay was made between a laboratory in Paris and our own, in order to assess objectively the Human Basophil Degranulation test (TDBH). The study was made on 28 subjects. They presented with anaphylactic or systemic reactions to hymenoptera venom. The samples from these patients were sent to Paris without any other diagnostic information. Agreement of results between ANGERS and PARIS was very poor, at around 38.5%. Agreement between the TDBH at ANGERS and PARIS with other biological parameters and skin tests was also weak, at 41.7 to 55% in ANGERS and 45.8 to 58.3% in PARIS. The techniques used at ANGERS and PARIS were the same. Overall, TDBH does not seem to be either reliable or reproducible between two laboratories, in the special case of hypersensitivity to hymenoptera venoms.

Anaphylaxis↗

PubMed1988

[Antihistaminic or anti-degranulating activity of pregnancy serum].

From observation of women who had anaphylactic accidents to hymenoptera venoms, with positive histamine release, we have noticed that these same patients lose their histamine release during pregnancy. Measurement of histamine release to pollens confirms the existence of a histaminase, which develops from the third month of the pregnancy and which is the origin of the loss of histamine release. This study makes eliminates a possible anti-degranulation ability of pregnancy sera.

Amine Oxidase (Copper-Containing)↗

PubMed1988

[Bibliographic review of antihistaminics H2 in the treatment of chronic (or recurrent) idiopathic urticaria].

Cimetidine alone has not been shown conclusively to be effective in the treatment of urticaria. Cimetidine in combination with an H1 antihistamine has been shown to be effective in studies of patients who could not be controlled by H1 antihistamine alone. In that section of the patient population with "untreatable" chronic urticaria, the use of an H2 antagonist in conjunction with an H1 antagonist should be considered as a possible treatment.

Histamine H1 Antagonists↗

PubMed1988

[Must the concept of intrinsic asthma be supported?].

Intrinsic asthma, defined as asthma which is not from allergy to pneumo-allergens, of cause unknown, may show several etiologies. Allergics, remembering that there in some subjects there may be small amounts of IgE on the mastocytes, with specific RAST IgE negative, skin tests only weakly positive, but with a positive provocation test to pneumo-allergens. Food allergy, isolated and associated, may also contribute a not-negligible cause. Non-allergics, responding to the frequent triggering factors: Gastro-oesophageal reflux; Neuro-endocrine origin; Infections; Physical origin (exercise). In our study, we quote two types of extremely severe asthma, linked to intolerance to aspirin and metabisulfites with others that are associated.

Asthma↗

PubMed1988

[Comparative study of ELISA and RIA technics for the detection of specific IgG4].

The assay of IgG4 was done by an ELISA method that has been perfected in our laboratory over two years, or by the RIA (Pharmacia technique). Assay of IgG4 is an objective element in the control of specific immunotherapy (IT) to hymenoptera venoms and grass pollens. There is an excellent correlation between the two techniques of ELISA and RIA, that shows an increase in IgG4 titre after around 3 to 4 years of IT.

Antibody Specificity↗

PubMed1988

[Local and general experimental anti-anaphylactic effect of 554 L, a synthetic antihistaminic].

554 L, a synthetic histamine depressant, was first made in September 1956. In spite of the age of this compound, it seemed to us that it may be of interest to examine it for possible experimental general and localised bronchial antianaphylactic activity. In the first experiments, the results showed an anti-anaphylactic effect in guinea pigs that had been sensitised to cow milk. The second study proved that there was an anti-anaphylactic effect locally on the bronchii by an aerosol of 554 L or Hypostamine on guinea pigs that were sensitive to OVA. These results may produce development of this old compound in delayed release and aerosol presentations.

Animals↗

PubMed1988

[Type I hypersensitivity to latex].

Allergy to latex causes serious accidents that are often unrecognised. These accidents are perfectly predictable by a simple interrogation, together with skin and biological tests. Populations at risk can be identified: persons undergoing treatment, particularly the disabled and also housewives. There is a risk of further increases in the number of cases of hypersensitivity to latex due to the expanding use of preservatives. The study undertaken at the CHU at Angers has shown that allergy to fruits is frequent in patients who are sensitive to latex. The exact nature of allergy to Hevea is not yet well understood: it is not possible at present to decide whether there is "crossed allergy" or whether it is one part of a larger syndrome.

Adult↗

PubMed1988

[Cell-mediated immunity using anti-influenza vaccine (AIV) and an immunostimulant (R)].

21 infected asthmatics were involved in this study, divided into three groups: Group 1 (G1): 7 subjects who received Ribomunyl. Group 2 (G2): 7 subjects who received anti-influenza vaccine, replaced on the 8th day by Ribomunyl. Group 3 (G3): 7 subjects who received the anti-influenza vaccine. Every patient had a IMC assessment on days 0, 8 and 30 that was composed of: 1. An RE test to show the Ly T11 receptors. 2. A study of the lymphocyte sub-populations CD3, CD4 and CD8, that respectively exhibit the LyT, T-helper and T-suppressor receptors. 3. Lymphocyte function was studied by stimulation of the lymphocytes by lectins, PHA (Ly T), Con A (Ly Ts) PKWM (Ly 8): by TB co-operation). 4. Measurement of total IgE. Only the lymphocyte stimulation tests by lectins showed a significantly raised response in the subjects of G1, who received Ribomunyl. IAV and Ribomunyl (G2) or IAV alone (G3) showed lymphocytes responses that were statistically less than G1. It seemed as though the IAV retarded the Ribomunyl response in IMC. The RE test and the study of the sub-populations did not show any significant differences between the groups. No differences between the total IgE levels could be seen in the groups. This study indicates the possibilities in the treatment of super-infected asthmatics with Ribomunyl alone, since the anti-influenza vaccine had a tendency to retard cell-mediated immunity.

Adjuvants, Immunologic↗

PubMed1988

[Cell-mediated immunity in antibiotic therapy].

Should antibiotic therapy required in the treatment of acute infection be administered frequently in patients at risk with clinical conditions involving recurrent superinfection? The results of our ongoing investigations initiated in 1967 and the present study indicate that macrolides, particularly erythromycin depress the host defense system. In contrast in a study performed in subjects treated for 8 days using cell-immunity tests, we found that cefaclor and amoxicillin may have an enhancing effect on host defenses.

Amoxicillin↗

PubMed1988

[Determination of specific IgE by chemiluminescence. The IgE DHS-CLA system].

The DHS-CLA IgE system (MAST immunosystems) allows simultaneous determination of specific IgE for 35 different allergens. The method here described is compared with RAST and results are in good agreement with allergic etiology. CLA testing appears to be a good alternative when anamnesis does not permit a clear diagnostic orientation.

Animals↗

PubMed1988

[Open trial on the tolerance to Rhinaaxia in allergic rhinitis].

Forty-four patients, most of them with strong symptoms, were included in this study of the tolerance and efficacy of Rhinaaxia in the treatment of allergic rhinitis. Thirty two patients had good or very good tolerance. Others reported nasal irritation and sneezes after the sprays and one left the study for this reason. The efficacy on nasal symptoms is also very clear. On the third day of treatment the decrease of the nasal trouble was already significant.

Aerosols↗

PubMed1987

[Determination of specific IgG4 in allergy].

Measurement of the titre of specific IgG4 by the ELISA method may provide objective assistance to the control of specific immunotherapy (IS) to hymenoptera venom and grass pollens. A marked increase of the specific IgG4 titre in the first 3 months of IS or a titre already raised before the start of IS correlated with poor clinical results. Specific IgG4 can not be considered to be a diagnostic indicator in food allergy since we have frequently found this type of antibody in control subjects. Specific IgG4 in food allergy expresses a mucosal marker rather than a pathological reaction.

Adolescent↗

PubMed1987

[Food allergy].

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Cromolyn Sodium↗

PubMed1987

[Determination of histamine].

Introduction of the radio-immunological technique (IMMUNOTECH, Marseille) for the measurement of histamine will in the future facilitate measurement of this mediator and this will be specially interesting during provocation tests for food and drug allergies and for histamine release in anaphylactic accidents caused by hymenoptera venom. The technique is more sensitive than that of the automated fluorimetric analysis.

Adult↗

PubMed1987

[Determination of specific serum IgG4 by an enzyme immunoassay].

Specific series IgG4 titrate is realized now with a enzymo-immunologic using "double sandwich" method with allergen and patient serum in presence of a conjugate with peroxidase monoclonal Anti IgG4. Calibration obtains with a standard curve, is realized with a monoclonal IgG4 concentration is known. The first tests are in favor of correlation between specific IgG4 specific, IgE and in another way, the increase of specific IgE and specific IgG4 in a venom immunotherapy.

Animals↗