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Biomedical subjects

A Sabbah

Publications and source records attributed to A Sabbah.

At least 163 records · Page 9Linked to original sources
PubMed1987

[Hyper-accelerated immunotherapy with Hymenoptera venoms].

Hyper-accelerated immunotherapy with hymenoptera venoms. Immunotherapy with hymenoptera venoms can be done in 3.5 to 6 hours, in a hospital environment with the precaution of having made a threshold of cutaneous sensitivity. The 3.5 h technique should only be used for subjects who are weakly sensitive to wasp venom. The 6 h technique should be used for: Subjects with weak sensitisation to been and hornet venom. Those who are strongly sensitive to wasp venom. The 3 day technique should be used for those who are strongly sensitive to been and hornet venom. This division of the indications is essentially based on skin tests. By its use, systemic reactions or indeed anaphylaxis that may occur during desensitisation may be avoided.

Anaphylaxis↗
PubMed1987

[ImmunoComb--reliability and reproducibility].

ImmunoComb is a solid phase in vitro immunological test for the measurement of serum or plasma total IgE. The technique was compared with PRIST for measurement of total IgE. The study also included reproducibility, on a test serum dilution both on a complete plate and plate sections. Statistically the conclusion is that ImmunoComb is a colourimetric test that gives the exact total IgE titre with good reproducibility. Use of a photometer greatly improves the sensitivity of assessing the results.

Humans↗
PubMed1987

[Intolerance to metabisulfites in asthma induced by aspirin].

38% of subjects who presented with aspirin (Acetyl-salicylic acid AAS)-included asthma were also found to be intolerant to metabisulphites (MBS). The diagnosis was based on interrogation and an oral provocation test (TPO), to which the majority of the responses were similar, immediate and/or delayed. Atopy and other immunological tests are not involved in this type of asthma, which like AAS is has an intolerance mechanism.

Administration, Oral↗
PubMed1987

[Epidemiologic survey on the living conditions of asthmatic patients].

Study of the living conditions of asthmatic subjects in comparison to a reference group showed that orientation of rooms to the East or North is much more frequent in asthmatics than in the reference group. This may explain the resistance to desensitization to mites found in some asthmatics.

Adolescent↗
PubMed1987

[Reactions to metabisulfites in aspirin-induced asthma].

We have observed in some patients that some Aspirin sensitive asthmatic present also a dyspnea after wine or foods containing sulfites ingestion. Owing to a study using ingestion test, with spirometric control, we show that sulfite sensitive asthma is more frequent in patients with Aspirin sensitive asthma than in the others. In the two cases, these molecules trigger off an asthma attack with same symptomatology, same severity, that is to say, frequently of IV type, with corticodependance. Diagnosis allow to an adapted treatment and so a better prognosis of these asthma.

Adult↗
PubMed1987

[Identification of common antigens of Phleum pollen and wheat. Preliminary study].

The typing of common Phleol Pollen and wheat Antigen has been realized with these Antigens Fractions from PASTEUR Institute using FPLC PHARMACIA Chromatograph. The discover of commun Antigen has been obtained with RAST Inhibition technic. It exist common Antigen fractions between phleol and wheat, but no between wheat an phleol. The results are in favor of less allergic quality of wheat.

Allergens↗
PubMed1986

[Interpretation of reactions to acetylsalicylic acid and glaphenine].

Challenge test puts in evidence the responsibility of a drug. The biological checking by plasmatic histamine leads to distinguish between a specific histamine-release reaction and a non-specific one. Thus, glafenine has proved to be a non specific histamine release where as in some cases, acetyl-salicylic-acid (A.S.A.) behaves like a specific histamine release.

Adult↗
PubMed1986

[Management of suspected allergy to lidocaine].

General Anaesthetics are potentially more dangerous than local anaesthetics. Among the achievement of 25 provocation tests, it always shows good tolerance of the local anaesthetic, included in patients who had presented serious disorders after a previous local anaesthesia. Consequently, the local anaesthetic wasn't the real cause. However, there is to say that in one case 45 minutes after challenge, hand oedema (occurred). Research of hypersensitivity, remains very necessary in every doubtful case.

Drug Hypersensitivity↗
PubMed1986

[Type III (Arthus) reaction during desensitization].

We rapport an original observation of adverse reaction (Arthus reaction) during a dust mite hyposensitisation with a aluminum hydroxide absorbed extract. We precise the way of beginning. In discussion, we try to precise the preliminary symptoms of such reaction to prevent it.

Adult↗
PubMed1986

[Level of total serum IgG4 using ELISA].

We report on an indirect competitive immunoenzymatic assay (ELISA) for the determination of serum total IgG4 levels. This procedure allows accurate and sensitive measurements. Normal values vary according to age and sex, with mean normal levels of 22.3 +/- 14.6 mg/dl in adults. Serum IgG4 levels observed in atopic subjects are not significantly different from those in age and sex matched normal subjects. However, IgG4 levels are significantly increased in hay fever and honey bee sensitization. Measurement of serum total IgG4 levels clearly needs to be combined with the evaluation of specific anti-allergen antibodies of this subclass in investigations of the possible reaginic or blocking activity of IgG4 antibodies.

Adult↗
PubMed1986

[Comparative effects of pressurized sodium cromoglycate aerosol and placebo in the treatment of allergic asthma].

28 young adults suffering from allergic perennial asthma have been treated by Lomudal spray or a matching placebo for 4 weeks. Judgment criteria were symptoms evolution, number of crisis, functional respiratory tests before and after treatment, patients and clinician judgments of efficacy and tolerance. Results of functional respiratory tests remind unchanged while symptomatology improved significantly. The total number of crisis was dramatically reduced by sodium cromoglycate treatment compared to placebo. Judgments significantly favoured sodium cromoglycate. Tolerance was excellent in both group.

Adult↗
PubMed1986

[Diagnosis of drug-induced allergy].

Drug allergy must be in relation with a phenomenon of immunopathology which induces: Anaphylactic shock; Toxidermia; Cytopenia; Allergic Hepatitis. Diagnosis is based on the cutaneous testing and "in vitro" tests. The evidence of drug responsibility will be supplied by challenge test, practised in hospital according to special conditions. Treatment is preventive with cortisone, epinephrine, antihistamine. Treatment is also curative with those same drugs in respect to the clinical pathology.

Drug Hypersensitivity↗
PubMed1986

[Effects and complications of specific immunotherapy].

During the specific immunotherapy, we observe: -local reactions -systemic reactions. In most cases, it is an exacerbation of clinic symptomatology which may reach others organs nearby. Reactions will occur more or less quickly according to the kind of the extract: aqueous or delayed. Clinically, systemic reactions can induce a general trouble or an anaphylactic shock. Numerous causes could be at the beginning of these systemic reactions in relationship to an antigenic overdose or to a promoting state of health. We can observe systemic reactions at most for grass pollens or hymenoptera venoms. Standardisation of allergens is not riskless. On the opposite, it needs a best knowledge of standards which change from one laboratory to another. During specific immunotherapy of hymenoptera venom, when histamine release is positive again in more than sixty per cent we can observe correlation with systemic reactions. Epinephrine is mostly essential in treatment of anaphylactic reaction. Prevention of incidents and accidents of specific immunotherapy depends on a clinical care. This can be obtained by an expert of allergy who will be in relation with the family doctor.

Bee Venoms↗
PubMed1986

[An immunoregulator of asthma: Ribomunyl].

A double blind check was conducted in two groups of patients with asthma to test ribosomal fraction (Ribomunyl) in a new tablet form: -the first group of 15 patients received the active medicine; -the second group of 9 patients were given placebos. The therapy consisted in prescribing 3 tablets a day for the first 4 days of the week for 3 weeks, next to stop treatment for one month, then to resume treatment for 4 days every month. Clinical improvement was reported in patients who were given the medicine. The "Rosettes" Test is in favor of a stimulation of T lymphocytes with correction of the cellular mediation deficit in the groups that received treatment.

Adjuvants, Immunologic↗
PubMed1986

[Complications induced by general anesthetics].

We reported 38 observations with adverse reactions during anesthesia. These observations have collected over about one year. For each observation we studied some parameters like sex, aspect of the adverse reaction, number of general anesthesia before the accident, atopy, age etc. Among the parameters, we noticed the great frequency of reaction in the female group (81.5%) and an increased level of total IgE (greater than or equal to 150 Ul/ml) in 38%. For each investigated drug we realized skin test (Prick-test and when negative, intra-dermal test) and Lymphoblastic Transformation Test L.T.T.). The examinations are compared each other for a best diagnosis: when skin test (ST) and L.T.T. are together positive the allergic reaction is likely. when ST and L.T.T. are together negative, it is likely there is not allergic reactions with this drug. when there is a discordance between ST and L.T.T. prudently we recommend to avoid this drug for future anesthesia. Results of ST and L.T.T. are detailed for the 3 drugs which are more often investigated. That is to say: Thiopental, Suxamethonium, Fentanyl.

Adolescent↗