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Biomedical subjects

A Rubin

Publications and source records attributed to A Rubin.

At least 145 records · Page 8Linked to original sources
PubMed1980

Pregnancy following conization of the cervix: complications related to cone size.

A retrospective study of 88 pregnancies occurring in 77 patients after cervical conization was undertaken to compare pregnancy outcome with cone size. Cone specimens were divided into two groups. Those measuring less than 2 cm in height or less than 4 cc in volume were considered to be "small cones" and those greater than 2 cm in height or 4 cc in volume were regarded as "large cones." The over-all normal term vaginal delivery rate was 46.6%, and was found to be inversely proportional to the size of the cone. The incidence of both spontaneous midtrimester abortion and prematurity increased in direct proportion to cone size. Cervical stenosis necessitating cesarean section was, however, noted to be a complication associated with small rather than large cones. It was concluded from this study that all postcone pregnancies should be regarded as high risk, preterm complications being particularly related to large cones.

Abortion, Spontaneous↗
PubMed1980

Comparison between intraamniotic PGF2 alpha and vaginal PGE2 for second-trimester abortion.

Two hundred three consecutive patients undergoing second-trimester abortion with either intraamniotic prostaglandin F2 alpha (PGF2 alpha) or vaginal prostaglandin E2 (PGE2) were compared. There were no statistical differences between the 2 groups with regard to age, race, gravidity, or gestational age. The average induction-to-abortion (I-A) interval for PGF2 alpha was 18.53 hours, compared with 13.25 hours for PGE2. The largest difference was in primigravidas (PGE2 6 hours shorter). There was no difference in the frequency of completed abortions in each group (approximately 50%). No correlation was found between gestational age and the I-A interval or percentage of complete abortions. Percentage of abortions completed by 24 hours or less was 97.6% for PGE2, versus 78.5% for PGF2 alpha. Abortions with PGE2 required a larger total prostaglandin dose and a cost 2.8 times greater than did those with PGF2 alpha. Side effects of vomiting, diarrhea, pyrexia, and hypotension were significantly more frequent with PGE2 suppositories. Hypertension was statistically more common with PGF2 alpha. In pregnancy of less than 16 weeks' duration, the known difficulty in performing amniocentesis and the proved shorter I-A interval with PGE2 imply that vaginal suppositories are the agent of choice prior to 16 weeks' gestation.

Abortion, Induced↗
PubMed1980

Rupture of the pregnant uterus.

Ninety-three incidents of uterine rupture are reviewed. There is a distinct difference in both the fetal and maternal outcome between the group with a previously scarred uterus and the group with no previous scarring. Rupture of the unscarred uterus is a more dramatic event. The most common etiologic factors appear to be oxytocin, cephalopelvic disproportion, grand multiparity, and abruptio placentae. Abruptio placentae was diagnosed in almost half the maternal deaths. When the uterine tear is longitudinal, the maternal and fetal prognosis is relatively poor. Fetal mortality is much higher in patients with an unscarred uterus. Hysterectomy was more commonly performed in this group. Rupture of a previously scarred uterus is usually incomplete and the tear is transverse. Maternal and fetal prognosis is much better and repair of the uterus with sterilization is more often feasible in this situation.

Abruptio Placentae↗
PubMed1979

Informed consent.

Explore the source record for details and available documents.

Dentist-Patient Relations↗
PubMed1978

Physiologic disposition of lergotrile.

Lergotrile, an ergot alkaloid, has been shown to be effective in treating disorders associated with elevated serum prolactin levels (e.g., galactorrhea-amenorrhea). Lergotrile has also been found to be a potent dopaminergic agonist and thus to be effective in Parkinson's disease. This study describes the physiologic disposition of lergotrile after administration to human volunteers. N-14CH3-lergotrile was rapidly absorbed from the gastrointestinal tract. Lergotrile was detected at low concentrations in plasma when subjects received large doses over extended periods of time. The major portion of radioactivity in plasma was attributed to the presence of circulating metabolites of lergotrile. Lergotrile metabolities were eliminated in the feces (ca. 60%), urine (ca. 20%), and breath (ca. 7% as 14CO2). A metabolite in feces was identified as 13-OH-lergotrile (up to 30% of the dose). A metabolite in urine was formed by conversion of the C8-acetonitrile group of lergotrile to a carboxyl group (about 10% of the dose). The presence of 14CO2 in the expired air after administering N-14C-methyl-lergotrile indicated that the drug was N-demethylated to form norlergotrile.

Acetonitriles↗
PubMed1978

Commitment to community mental health aftercare services: staffing and structural implications.

This study examines the views of community mental health practitioners toward aftercare services and deinstitutionalized patients. A survey of 361 practitioners in Allegheny County, Pennsylvania, finds that these views are related to practitioner experience in psychotherapeutic practice, professional affiliation, educational level, and amount of specialization in aftercare. Implications are drawn for staffing and structuring community mental health aftercare services in ways that are likely to enhance practitioner committment to aftercare.

Aftercare↗
PubMed1977

Physiologic disposition of nabilone, a cannabinol derivative, in man.

Nabilone is a cannabinoid that is being evaluated in man as a potentially useful psychoactive drug. We found that nabilone was readily absorbed from the human gastrointestinal tract when administered orally as a coprecipitate with polyvinyl-pyrrolidone. The absorbed drug disappeared from plasma rather rapidly (half-life, approximately 2 hr), evidently due to extensive tissue distribution and rapid metabolism. The metabolites of nabilone persist in plasma for extended periods (half-life of total radioactivity exceeds 20 hr). Circulating metabolites include isomeric carbinols formed by reduction of the ketone in the 9-position of nabilone. Nabilone is eliminated in feces (about 65% of dose) and urine (20%). The excretory products in urine have not been identified, but metabolites that are labile to hydrolysis by beta-glucuronidase or sulfatase do not appear to be formed in significant amounts. A metabolite of nabilone in feces has been identified as a diol formed by reduction of the 9-keto group plus oxidation at the penultimate carbon of the dimethylheptyl side chain. The long duration of action of nabilone in the face of rapid and extensive metabolic elimination suggests that the pharmacologic effects, at least in part, may be exerted by one or more active metabolites.

Administration, Oral↗