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Biomedical subjects

A Rubin

Publications and source records attributed to A Rubin.

At least 127 records · Page 7Linked to original sources

Tetracycline and amphotericin B vaginal cream for mixed vaginal infections.

A tetracycline and amphotericin B vaginal cream (Vagmycin; Squibb) was highly effective in mixed vaginal infections. More than 95% of patients had symptomatic relief while 85% showed bacterial and clinical response. There appeared to be little difference whether the cream was applied for 1 week or 2 weeks. A group of asymptomatic patients were evaluated to compare alterations in normal and pathological organisms as a result of treatment.

Amphotericin B↗

Colpotomy drainage of pelvic abscesses.

Retrospectively the records of 155 patients with an acute pelvic abscess who were treated by colpotomy drainage were studied. The more aggressive management, i.e. surgery, is to be preferred and the vaginal approach gives good results. The complications and morbidity in this series were very low and the mortality less than 1%. The procedure itself is simple and requires no special skill or great experience.

Abscess↗

Ludwig's angina following dental extraction as a cause of necrotizing mediastinitis.

A fatal case of Ludwig's angina is reported in which penicillin was used as the sole antibiotic. Bacteroides melanogenicus resistant by virtue of production of Beta-lactamase was present. It is suggested that a combination of penicillin and an antibiotic effective against anaerobes such as metronidazole is the most appropriate initial chemotherapy pending confirmation from the bacteriology laboratory.

Adult↗

Greater omentum used for carotid cover after pharyngolaryngoesophagectomy and gastric 'pull-up' or colonic 'swing'.

An excellent method of rehabilitation for swallowing after total pharyngolaryngoesophagectomy is the reconstruction of the pharyngoesophagus with an autogenous visceral transplant. The most popular and reliable methods are the gastric "pull-up" and colonic "swing." A complication of this procedure--which can result in morbidity as well as mortality--is carotid artery rupture, especially when a neck dissection is performed. This is usually the result of wound breakdown secondary to adjunctive use of radiotherapy. When we have performed a radical neck dissection in conjunction with a visceral transplantation, we have used pedicled omentum as a live, durable cover for the carotid artery. ?

Carotid Artery Diseases↗

Mental health service priorities and the BSW.

New Priorities in mental health service delivery call for the exploration of previously overlooked sources of mental health personnel whose preparation for practice is adapted to historically underserved populations and service delivery approaches geared to their special needs. One such source are baccalaureate level social workers. This exploratory study of 29 purposively selected baccalaureate social work education programs observes and describes their extensive mental health field instruction, in which the predominant student assignments include case management and related functions stressed in current mental health policy. Implications are drawn regarding the allocation of federal training funds and labor force issues.

Community Mental Health Services↗

Physiologic disposition of pergolide.

Pergolide, a synthetic ergoline, is a potent long-acting dopaminergic drug effective in Parkinson's disease and amenorrhea-galactorrhea. After 138 micrograms 14C-pergolide orally to healthy subjects, radioactivity was present in plasma and red blood cells. Salivary radioactivity was one third to one tenth that in plasma. Radioactivity in plasma appeared after 15 to 30 min, peaked at 1 to 2 hr, and was barely detectable after 96 hr. Plasma radioactivity was not attributable to pergolide, and the levels did not correlate well with the duration of the prolactin-lowering effect induced by pergolide. Pergolide became bound to several plasma proteins and could not be displaced by other drugs that are also bound or by possible metabolites of pergolide. Radioactivity was eliminated as pergolide metabolites in urine (55%), feces (40%), and breath (5%, as 14CO2).

Adult↗

Vaginal discharge in the black pregnant patient: an evaluation of the relationship between symptomatology and diagnosis.

Three hundred and thirty pregnant Black antenatal patients with symptomatic vaginal discharge were assessed. There appeared to be no correlation between the symptoms (pruritus, burning, amount of discharge and appearance) and the expected diagnosis. The common organisms Trichomonas vaginalis, Haemophilus vaginalis, Candida albicans and Neisseria gonorrhoeae were evaluated. It was also noted that a large number of patients (54%) had negative cultures although their complaints were similar to those of patients with positive cultures.

Candida albicans↗

Efficacy of econazole in the treatment of candidiasis and other vaginal discharges.

Three hundred and thirty Black pregnant patients attending the Baragwanath Hospital antenatal clinic were treated for symptomatic vaginal discharge with econazole (Ecostatin; Squibb). Patients with positive Candida albicans cultures were treated for either 7 or 14 days. The results of treatment in both groups are presented.

Candidiasis, Vulvovaginal↗