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Biomedical subjects

A R Hunter

Publications and source records attributed to A R Hunter.

At least 37 records · Page 2Linked to original sources
PubMed1984

Experimental infection of castrated lambs with Mycoplasma agalactiae.

The course of experimental infection in groups of 6-month-old castrated lambs with field isolates of Mycoplasma agalactiae from France was followed culturally and serologically for 7 months. Infection with an ovine field isolate following inoculation by different routes and contact exposure was compared with that caused similarly by a caprine field isolate. The prolonged infections produced were symptomless apart from limited arthritis in one animal inoculated with the isolate from sheep and increased lachrymation in another associated with the goat isolate. The ovine isolate was more virulent in that ante- and post-mortem recoveries of the organism were more consistent and the serological responses more pronounced. Serological responses varied between animals and between strain infections, and the results of the film inhibition test were more consistent than those of the complement fixation test. The limitations of both these tests for detecting carrier infections are discussed.

Animals↗
PubMed1983

Histopathological findings in the lungs of Scottish red and roe deer.

Histopathology on portions of lung collected from 34 red deer (Cervus elaphus) and 15 roe deer (Capreolus capreolus) between 1977 and 1981 revealed evidence of lungworm infestation in 16 red and 14 roe deer. In the red deer, Dictyocaulus species, and the developmental stages of another parasite, believed to be Elaphostrongylus cervi, were involved. Dictyocaulus also affected the roe deer, but in them the major lesions were associated with protostrongylids. Exudative bronchopneumonia, including two cases of fungal infection, was predominantly a problem of red deer under seven months of age. Between the age of four and seven months, parasites frequently accompanied this change. Other conditions encountered were pulmonary congestion, tuberculosis and granulomata of unknown cause.

Animals↗
PubMed1983

A comparison of the effects of dialysed and non-dialysed transfer factor preparations on Haemonchus contortus infections in young lambs.

Significant reductions in worm burdens were achieved in lambs treated with dialysed transfer factor and challenged with 10,000 Haemonchus contortus larvae, when compared with challenged control animals. Non-dialysed transfer factor, from the same leucocyte pool, produced no protection, but was successful in reducing worm burdens when given after a primary infection of 1,000 H. contortus larvae with subsequent challenge of 10,000 larvae. While the results confirmed the previously reported inconsistencies of transfer factor activity, the histological abomasal changes in all the dialysed and non-dialysed transfer factor treated groups, irrespective of measurable effects on worm burdens, were consistent and corresponded to immediate type hypersensitivity responses. The similarity of these responses with self cure in haemonchosis and the possibility of genetic factors influencing the quantitative expression of protection to the effects of transfer factor treatments is discussed.

Abomasum↗
PubMed1983

The effects of transfer factor, parasitic antigen and precipitated immunoglobulin treatments in lambs infected with Haemonchus contortus.

Significant reductions in adult worm burdens in lambs less than six months old infected with 5000 third stage Haemonchus contortus larvae were achieved following the combination of a single transfer factor treatment with multiple parenteral treatments of adult parasitic antigen and precipitated immunoglobulin. Specific cellular responses in the abomasa associated with individual treatments were discernible in all the experimental groups and quantitative differences in these responses reflected the varying treatment levels and treatment combinations. The reactions associated with transfer factor were similar to immediate type hypersensitivity responses and their role as possible effector mechanisms in correcting partial immune incompetency in lambs is discussed.

Abomasum↗
PubMed1983

Heterozygotes for atypical cholinesterase.

Three hundred and thirty-two patients undergoing electroconvulsive therapy received thiopentone and suxamethonium. In 31 the duration of the apnoea was greater than an assumed upper limit of normal of 240 s. Eight of these patients proved, on biochemical grounds, to be heterozygotes for the atypical gene. The reason why the heterozygous state is rarely present in those who have prolonged apnoea is that the vast majority of those who suffer from this abnormality are only slightly more sensitive to suxamethonium than are normal individuals.

Adolescent↗
PubMed1983

Bridging the gap.

Explore the source record for details and available documents.

Communication↗
PubMed1983

Anaesthesia-related surgical mortality.

This is the report of the second of two studies conducted by the Association of Anaesthetists of Great Britain and Ireland based on anonymous reports of deaths within 6 days of anaesthesia. One hundred and ninety-seven detailed reports were received during 1981; 43% were found by assessors to have nothing to do with anaesthesia, 41% to be partly due to, and 16% totally due to anaesthesia. These figures confirm earlier results reported by the same system. It is important to have the opinion of the two clinicians (anaesthetist and surgeon) separately and not to ignore either in a study which attempts to identify aspects of clinical medicine which might be improved.

Aged↗
PubMed1983

Zebulon Mennell. A pioneer of neurosurgical anaesthesia.

Dr. Zebulon Mennell, the first anaesthetist to devote himself largely to anaesthesia for neurosurgery, was born on 15 June 1876. He graduated at St. Thomas's Hospital in London, where he was an anaesthetist. He was also an anaesthetist at the Royal National Hospital for Nervous Diseases, Queen Square, London, a post which he held until 1945. His writings indicate that he appreciated the problems of neurosurgical anaesthesia and he was the first individual to work in this field as a specialist.

Anesthesia, Inhalation↗
PubMed1982

Experimental infections with Dictyocaulus viviparus in vaccinated and unvaccinated red deer.

Four of eight red deer calves which had been artificially reared and were lungworm free were vaccinated with bovine lungworm oral vaccine when eight weeks old; the other four were not vaccinated. Three of each category were challenged daily with 500 Dictyocaulus viviparus infective stage larvae per kg liveweight for 17 days when six months old while one in each category was left as an unchallenged control. The effects of challenge were monitored and all challenged deer and one control were killed for post mortem assessment. Challenge with D viviparus was associated with reduced food intakes and weight gains but vaccinated calves were less affected than unvaccinated ones. The reaction of the alveolar tissue of red deer lung to D viviparus was mild in vaccinated and unvaccinated animals and differed from that of bovine lung in that alveolar epithelialisation was limited and hyaline membrane formation and interstitial emphysema were not seen. The disease was most evident in and around airways and was less in vaccinated calves. It was concluded that young red deer are tolerant to D viviparus but will readily acquire infection.

Animals↗
PubMed1982

Pneumonia in sheep associated with dipping in carbolic dips.

Fourteen outbreaks of pneumonia in sheep following dipping in carbolic dips were investigated at seven laboratories. Deaths commonly occurred between one and three days after dipping and fat young sheep of the Suffolk and Border Leicester breeds were most usually involved in outbreaks. The pneumonia was characterised by hyperaemic, oedematous and cyanotic lungs, and the main histological features were hyperaemia, fluid and cellular exudation into alveolar spaces, and widespread epithelialisation of alveolar walls. The microscopic changes differed from pneumonic pasteurellosis and no significant organisms were recovered from any of the lungs. One of 27 Dorset Horn lambs dipped in a batch of dip which had been incriminated in some episodes developed an epithelialising interstitial pneumonia, while two out of three Suffolk lambs dipped in twice the recommended strength of the same batch of dip became ill with severe pneumonia, apparently following skin absorption.

Animals↗