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Biomedical subjects

A R Hunter

Publications and source records attributed to A R Hunter.

At least 19 recordsLinked to original sources
PubMed1991

The treatment of endodontically treated teeth.

Recently published studies on the treatment of endodontically treated teeth have confirmed and expanded on the restorative directions outlined in earlier work. The significance of endodontic treatment in reducing tooth strength has been questioned, and the potential influence of previous operative cavity designs highlighted. Other work has supported the contention that following the placement of a well-fitting crown, the strength of the post foundation, the core foundation, or both is relatively unimportant in determining the overall strength of endodontically treated teeth. In particular, it appears unnecessary to incorporate a ferrule effect as part of a post-and-core foundation. It seems that the height of the remaining tooth structure between the core and the crown margin is a much more significant factor in determining the fracture resistance of these teeth. Many articles have demonstrated the potential influence of material interactions at all stages of the restorative process. Further work in this area is likely to greatly complicate clinical decision making when restoring endodontically treated teeth.

Corrosion↗
PubMed1979

An outbreak of malignant catarrhal fever in red deer (Cervus elephus).

Nine of 15 housed red deer developed an acute disease. Six died and three were killed when severely affected. The clinical and post mortem changes suggested a diagnosis of malignant catarrhal fever (MCF) which was consistent with the pantropic lymphoproliferative histopathological lesions observed. Attempts to isolate an agent or transmit the condition to cattle failed. The relation of the vasculitis to the pathogenesis of the disease and the susceptibility of red deer are discussed.

Animals↗
PubMed1979

Correspondence.

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Anesthesiology↗
PubMed1978

MCQ and higher examinations as exemplified by the primary Fellowship of the Faculty of Anaesthetics, Royal College of Surgeons of England.

A major problem of the use of multiple choice examinations is the inherent difficulty of the questions, a fact which cannot be assessed in relation to questions not previously used. Questions which have been used during previous examinations, however, will have an available measure of the difficulty in the form of candidates' previous scores. The performance of candidates in a current examination can be compared with that in a previous examination. On the strength of these differences it is possible to decide whether the candidates in any single examination are better prepared than their predecessors or less well prepared. Pass marks can be appropriately adjusted.

Educational Measurement↗
PubMed1977

Pipe-line accident.

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Accident Prevention↗
PubMed1977

Pipe-line accident.

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Accident Prevention↗
PubMed1975

Control of haemoglobin synthesis. The effects of iron deprivation, cobalt and temperature on the rate and extent of globin synthesis in reticulocytes.

A detailed examination of the kinetics of protein synthesis in rabbit reticulocytes in the presence of the iron chelating agent 2,2'-dipyridyl showed that between 30 degrees C and 42 degrees C there were characteristically two distinct phases of protein synthesis. An initial phase (I), in which no inhibition of protein synthesis was apparent, was followed by a gradual decline in the rate of protein synthesis leading to the second phase (II) in which protein synthesis occurred at a linear but inhibited rate for extended periods. In contrast, below 30 degrees C, incubation in the presence of dipyridyl caused no inhibition of protein synthesis. Between 30 degrees C and 42 degrees C the duration and amount of protein synthesis occurring in phase I before the onset of inhibition were inversely related of the inhibition as was the final rate of incorporation in phase II. During phase II, a partial reversal of the inhibition caused by dipyridyl was obtained by lowering the incubation temperature. This resulted in a burst of protein synthesis at the uninhibited rate until the amount of protein synthesis reached the same level as that in reticulocytes maintained continuously with dipyridyl at the lower incubation temperature. This burst of synthesis was observed in reticulocytes which had been held in phase II for as long as 90 min. It was also possible to reverse the inhibition by addition of haemin to cells in phase II. At any particular incubation temperature, a fixed number of rounds of protein synthesis had to occur before the onset of phase II became apparent. By the use of puromycin we showed that this was not a requirement for the synthesis of globin or of any other protein. We believe that this critical amount of protein synthesis reflects the residual ability of reticulocytes to initiate new protein chains in the absence of concurrent haem synthesis. Reticulocytes preincubated in the presence of cobaltous ions showed almost no inhibition of protein synthesis upon subsequent incubation with dipyridyl. The results are compared to those obtained in reticulocyte lysates and are discussed in terms of current theories to account for control of protein chain initiation by haemin.

2,2'-Dipyridyl↗
PubMed1975

New drugs.

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Drug Industry↗