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Biomedical subjects

A Mihail

Publications and source records attributed to A Mihail.

At least 55 records · Page 3Linked to original sources
PubMedDate not supplied

[The humoral and cell-mediated immune response induced by the NIVGRIP inactivated influenza vaccine].

A comparative study was conducted in patients vaccinated with the NIVGRIP trivalent inactivated influenza vaccine and in placebo receiving controls on the kinetics of the serum hemagglutination inhibiting (HAI) antibodies and the neutralizing secretory antibodies in the nasopharyngeal secretions (NPS), of the blastic transformation of lymphocytes index, of the rosette formation index and of the serum immunoglobulins. A significant rise of the H.A.I. and the neutralizing secretory antibodies as well as of the blastic transformation of lymphocytes index was recorded after stimulation with the influenza vaccine. There were no significant changes in controls. No significant variations of the blastic transformation of lymphocytes index after stimulation with P.P.D. and of the rosette formation index were recorded in both investigated groups. Serum immunoglobulin titres showed significant variations in vaccinated as well as in control groups. The results point out the stimulating effect of the NIVGRIP inactivated influenza vaccine on both humoral and cell mediated immune responses.

Adult↗
PubMedDate not supplied

Research on respiratory virus diseases performed in the "Stefan S. Nicolau" Institute of Virology.

The studies on respiratory virus diseases performed for 30 years in the "Stefan S. Nicolau" Institute of Virology approached various aspects of the ecology of inlfuenza and parainfluenza viruses, adenoviruses and other respiratory viruses, including numerous experimental, fundamental, clinical and morphopathological investigations. Special attention was paid to specific influenza prophylaxis and to the preparation of an inactivated influenza vaccine applicable by nasal and oral route.

Animals↗
PubMedDate not supplied

Efficiency of the NIVGRIP inactivated influenza vaccine applied by oral route: evaluation in a community of pre-school children in the period 1981-84.

The NIVGRIP inactivated influenza vaccine prepared in the "Stefan S. Nicolau" Institute of Virology was administered by oral route to 3-6-year-old children of a preschool community in October 1981, 1982 and 1983. There were no cases of acute respiratory tract infection (ARTI) in the community in the winter seasons of 1981-82, 1982-83 and 1983-84, with the exception of 3 ARTI cases recorded in February 1982 in unvaccinated children. In a similar community where no vaccination had been performed morbidity by ARTI was of 20% in 1982-83 and 12.6% in 1983-84. The efficiency and the advantages of oral influenza vaccination are outlined.

Administration, Oral↗
PubMedDate not supplied

Comparative results of respiratory virus isolation attempts in chorioallantoic membrane fragments and embryonated chicken eggs.

Attempts performed with 39 samples of nasopharyngeal secretion resulted in the isolation of 21 (54%) hemagglutinating viral agents in chorioallantoic membrane (CAM) fragments, while a single strain (2.5%) was isolated in the embryonated egg. The time interval required for virus isolation in CAM fragments ranged from 4 to 20-24 days and was longer then 10 days in the embryonated egg. Maintenance of CAM fragments in roller tubes leads to a more abundant virus multiplication and, implicitly, to a reduction of the time interval necessary for virus isolation.

Allantois↗
PubMedDate not supplied

Epidemiological evaluation of the protection conferred by the Nivgrip vaccine against influenza caused by the A(H3N2) virus.

The protection conferred by the inactivated influenza vaccine Nivgrip against influenza caused by the A(H3N2) virus was demonstrated in three school communities of a large urban centre during the epidemic outbreaks occurring in the winter season of 1983. The specific protection was reflected by the lower morbidity by influenza-like respiratory infections and by the absence or scarcity of postinfluenza complications in vaccinees.

Adolescent↗
PubMedDate not supplied

Study of several genetic markers of two recombinants derived from autochthonous influenza virus type A strains.

Two recombinants derived from autochthonous influenza virus type A strains were studied as regards neuraminidase activity, the rate of elution from chicken RBC and the sensitivity to nonspecific horse serum inhibitors. Neuraminidase activity was lower in the A(H1N1) recombinant and in its collection and wild-type parents belonging to the same subtype than in the A(H3N2) recombinant and parental strains; the elution rate was much higher in the former than in the latter. In contrast to the parental strains, both recombinants were resistant to horse serum inhibitors.

Antiviral Agents↗