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Biomedical subjects

A Mihail

Publications and source records attributed to A Mihail.

65 records · Page 4Linked to original sources
PubMedDate not supplied

Study of recombinants derived from autochthonous influenza virus type A strains.

Simultaneous inoculation of chick embryos with a standard laboratory influenza virus--A/PR8/34 (H0N1)--and with an autochthonous epidemic strain--belonging to the antigenic subtype A(H1N1) of A(H3N2), respectively--resulted in the isolation of two genetic recombinants, designated R1IVN (H1N1) and R2IVN (H3N2). Each recombinant was antigenically identical to its wild-type parent and exhibited a hemagglutinating titer in chick embryos about 4-fold greater than that of the autochthonous parental strain.

Animals↗
PubMedDate not supplied

The course of some viral respiratory infections in the south-east area of Romania during the cold season 1993-1994. Epidemiological serological and viral data.

Since 1991 we studied yearly the course of some respiratory infections in nine districts of the south-east area of Romania, by collecting epidemiological and sero-viral data during the cold seasons (1) (2). The results pointed out the most frequent circulating viruses, as well as the influenza strains which caused epidemic outbreaks. The same line of investigation was followed during the cold season November 1993-- March 1994 in the mentioned geographic area. In the present study are shown the results obtained in this period.

Adolescent↗
PubMedDate not supplied

The evidence of circulation of some viruses in a great town of Romania during the first half of 1992.

Complex serological survey performed in the town B. during the first half of 1992 emphasized an active circulation of some respiratory viruses, especially of parainfluenza type 3 and 1, influenza subtypes A(H3N2) and A(H1N1), adeno and syncytial respiratory as well as of Mycoplasma pneumoniae. Less important was the frequence of antibodies against Chlamydia psittaci, East equine, West Nile and tick-borne encephalitis as well as parainfluenza type 2 and influenza type B viruses.

Adolescent↗
PubMedDate not supplied

Epidemiological, viral and serological studies concerning the evolution of some acute respiratory diseases between November 1992 and March 1993 in nine districts of the south-east area of Romania.

Viral and serological studies led to the conclusion that parainfluenza type 3 and influenza type A(H3N2) viruses were the most implicated in the etiology of acute respiratory diseases (ARD), viral pneumonia and clinical influenza in nine districts of the south-east area of Romania during the November 1992--March 1993 period. Epidemiological survey pointed on the 0-1 year group of age as the most affected by the above mentioned respiratory diseases.

Acute Disease↗
PubMedDate not supplied

The experience of the "Stefan S. Nicolau" Institue of Virology in the preparation of administration of inactivated influenza vaccines applicable by nasal or oral route.

Studies conducted for over 20 years allowed the authors to accumulate a rich experience in the production and administration of an inactivated influenza vaccine applicable by nasal and oral route, prepared in the "Stefan S. Nicolau" Institute of Virology. Applied as a monovalent in a single dose of 1000 IU, the vaccine induced seroconversion of 70% of the vaccines and ensured a 2--4-fold decrease in influenza morbidity. Owing to these qualities the vaccine represents one of the most advantageous preparations used in influenza prophylaxis.

Antibodies, Viral↗
PubMedDate not supplied

Studies concerning the course of some acute respiratory diseases in nine districts of south-east area of Romania between November 1994 and April 1995. Epidemiological, virological and serological data.

A moderate level of morbidity through acute respiratory diseases (ARD), of the upper tract, viral pneumonia and clinical influenza was recorded during November 1994 and April 1995 in the South-East area of Romania (nine districts). By virological and serological investigation adenosyncytial respiratory, parainfluenza type 3 and influenza type B viruses were found to be the most frequent etiological agents of these infections which affected especially the babies and the children of 1-14 years of age. Sporadic influenza outbreaks were noticed from which influenza strains of virus were isolated, antigenically related to the prototype strain A/Johannesburg 33/94.

Adolescent↗
PubMedDate not supplied

Bivalent influenza vaccination with inactivated vaccines administered by nasal or oral route.

Influenza vaccinations were performed either by administration of a bivalent A2 + B vaccine, or by successive application of monovalent B and A2 vaccines. During an influenza epidemic caused by an A2 strain, the following observations could be made: a) the best efficiency (no influenza cases) was recorded in adults and aged persons (over 65 years) irrespective of the vaccination scheme; b) in schoolchildren the best results (no influenza cases) were obtained in the lot having received monovalent A2 vaccine, and in the lot vaccinated nasally with monovalent B vaccine and 14 days later with monovalent A vaccine.

Administration, Intranasal↗
PubMedDate not supplied

Epidemiological, viral and serological studies concerning the evolution of some acute respiratory diseases between November 1992 and March 1993 in nine districts of the south-east area of Romania.

Viral and serological studies led to the conclusion that parainfluenza type 3 and influenza type A(H3N2) viruses were the most implicated in the etiology of acute respiratory diseases (ARD), viral pneumonia and clinical influenza in nine districts of the south-east area of Romania during the November 1992-March 1993 period. Epidemiological survey pointed on the 0-1 year group of age as the most affected by the above mentioned respiratory diseases.

Acute Disease↗
PubMedDate not supplied

Virological study of some influenza outbreaks in the period January--March 1975.

The virological study of some influenza outbreaks recorded in Romania in the period Jnauary--March 1975 resulted in the isolation of 29 influenza A2 virus strains antigenically close to the strains A2/Port Chalmers 1/73 and A2/England 42/72. The non-homogeneous antigenic structure of the isolates suggests the possible formation of natural hybrids.

Antigens, Viral↗