[Bromocriptine treatment indications in endocrine sterility].
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Biomedical subjects
Publications and source records attributed to A Maleeva.
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The concentrations of testosterone, estradiol, LH and FSH were studied in blood plasma of 84 healthy males and in the seminal plasma of 22 fertile males. The results obtained are juxtaposed to the concentrations of the indicated hormones in seminal fluid of 35 males with oligoasthenospermia and of 46 males with azoospermia. The concentration of the hormones in the seminal plasma was established to be equal to their concentrations in blood plasma. That enables their investigation in the seminal fluid in parallel with the spermogram. Normal fertility is admitted to be that fertility with a concentration of testosterone ranging from 250-550 mg%, of estradiol from 40-60 pg/ml, of LH-25-35 mlU/ml and of FSH from 20-30 mlU/ml. Reduced fertility has the concentrations of testosterone and estradiol reduced with more than 50% of the normal level, and that of gonadotropic--elevated with more than 50% of the normal level.
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Plasma concentrations of testosteron, LH, FSH were repeatedly followed up during a three-year hormonal treatment in 40 patients with comfirmed prostate carcinoma. The initial concentrations of the indicated hormones were established not to differ statistically from their levels in intact subjects and cannot serve as diagnostic criteria. With a drop of testosteron concentration under 70 per cent from the initial level, the treatment with hormonal preparations could be admitted successful and with a drop to 10 per cent--a maintaining therapy should be followed.
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A qualitatively new method is proposed for extraction and separation of progesterone from blood plasms, substituting the imported reagent hexane for the homeoproduced diethyl ether and the separating technique via freezing. The technical changes proposed improve the percentage of extraction of progesterone in blood plasma from 80 per cent to 95 per cent, making the method more sensitive to low concentrations of blood plasma progesterone.
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Cytogenetic investigations were carried out on 23 subjects and hormonal -- on 18 of them, working in the sphere of ionizing radiation at medical institutions. After the quantitative processing of the results from the cytogenetic investigations, statistically significant differences were established to exist in cell obtaining with aberations, chromozome and chromatide fragments as compared with the spontaneous frequency of healthy subjects. Statistically significant differences were observed also in the group with length of service over 10 years as regards the dicentrics obtaining as well. With the follow-up of hormone concentrations in blood plasma a statistical decrease was found in the level of sex hormones -- testosterone in males and progesterone in females, accompanied by increased level of FSH, suggesting a primarily damage of gonads (testis and ovaries). Plasma cortisol level is statistically significant increased in all subjects examined whereas aldosterone level is normal in subjects with a length of service to 10 years and statistically significant decrease with a length of service over 10 years.