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Biomedical subjects

A Maleeva

Publications and source records attributed to A Maleeva.

At least 37 records · Page 2Linked to original sources
PubMed1987

[Changes in hypophyseal-adrenal secretion in bronchial asthma patients].

The basic ACTH and cortisol (hydrocortisone) secretion was followed up in 678 patients suffering from bronchial asthma--494 men and 184 women, duration of the disease from 6 months up to 27 years. In 140 patients the 24 hour secretion of both hormones was studied. In 1/3 of the asthmatic patients the cortisol secretion was lower than the normal one (20.94%) or was near the lower normal range (14.01%). In about half of the patients the morning (at 8 o'clock) ACTH secretion was increased (53.10%). The disturbance of the basic hypophysial-suprarenal secretion was found more often in the patients with infectious bronchial asthma (24.9%) and with the mixed form than with the atopic form of the disease (12.0%). It probably takes part in the pathogenesis of infectious bronchial asthma. The corticosteroid treatment plays a leading role in reducing the basic cortisol secretion in asthmatic patients. In 53.85% of the asthmatic patients a disturbed 24 hour rhythm of cortisol secretion was found--inverse (30.71%) or monotone (27.14%). The rhythm disturbance was found more often in the patients with basic hypocortisolemia.

Adolescent↗
PubMed1984

Neuro-endocrine effects of isotheoline.

Experiments are carried out to study the effect of isotheoline (IST) on the secretion of prolactin (PRL), somatotrophic hormone (STH) and testosterone, using cats and Wistar albino rats of both sexes. PRL, STH and testosterone using cats and wistar albino rats of both sexes. PRL, STH and testosterone were determined radioimmunologically at the 10th, 60th and 120th min after the administration of IST in doses of 0.5 to 5 mg/kg. Comparative experiments were carried out with bromocryptine and glaucine--1 mg/kg i.p., as well as experiments involving the administration of IST on the background of the dopaminergic antagonists haloperidol and pymoside--1 mg/kg i.p. The results obtained show that in doses not exceeding 1 mg/ks IST increases the plasma level of testosterone and, similar to bromocryptine, reduces the plasma level of PRL and increases that of STH. These effects are less pronounced for the 5 mg/kg dose and they are antagonized by the dopaminergic antagonists used. It is assumed that IST, similar to bromocryptine, achieves the described effects through selective stimulation of the D2 dopaminergic receptors involved in neuro-endocrine mechanisms responsible for the control and release of the hormones studied.

Animals↗
PubMed1981

[Hypophyseal-ovarian disorders in chronic kidney failure].

The authors studied the plasma level of follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E) and progesterone (P) in 2 female patients with chronic renal insufficiency (ChRI), aged 21--42, without any genital ailments. The patients were conservatively treated. The authors found elevated plasma level of FSH and LH in the plasma of the female patients with ChRI and decreased E and P. The direct lesion of the hypophyseal-ovarial axis by uremic toxins is the reason, admitted by the authors for the hormonal dysbalance in the patients with ChRI. Similar changes are admitted to be found at the hypothalamus level as well. According to the authors the hormonal dysbalance in the female patients with ChRI is the cause for the grave changes observed in the genital cycle.

Adult↗
PubMed1981

[Plasma levels of follicle-stimulating and luteinizing hormones, prolactin and estradiol in women with chronic kidney failure on programmed hemodialysis].

The plasma level of FSH, LH, P and E of 24 women with CRI, aged from 16-61, on a programmed hemodialysis was determined, 13 of them with Balkan endemic nephropathy, 8--chronic pyelonephritis and one patient with chronic glomerulonephritis, polycystosis of kidneys and lupus nephritis. The patients were grouped into three groups according to age and genital cycle: with genital cycle--10, secondary amenorrhea--7, and in menopause--7. The patients with genital cycle were grouped as follows: 4 with eumenorrea, 4--opsomenorrhea and I with hyper- and I with hypomenorrhea. Plasma hormone level prior to and post hemodialysis was determined by radioimmunologic methods. The results obtained showed that FSH levels, as compared with the control group of healthy women, was unchanged, LH and P--was elevated and E was elevated only in the patients with genital cycle. No significant discrepancy was found in the levels of the hormones studied, in the three groups of females with CRI on programmed hemodialysis (with genital cycle, secondary amenorrhea and menopause), except for E in the women with cycle. The studies of the authors showed that plasma levels of FSH, LH, P and E prior to and post hemodialysis, are insignificantly changed. That provided grounds to admit that the hormones are nondialysable. The authors admit that the programmed hemodialysis is a treatment method by which the genital cycle in some CRI patients with secondary amenorrhea could be restored.

Adolescent↗