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Biomedical subjects

A Maleeva

Publications and source records attributed to A Maleeva.

At least 73 records · Page 4Linked to original sources
PubMed1978

[Dynamic study of the hypothalomo-hypophyseal-gonadal axis in patients with Klinefelter's syndrome].

Detailed clinical and hormonal studies were performed in 30 male patients with Klinefelter syndrome, proved by karyotyping. Diagnostic tests with LH-RH were carried out with application of 100 microgram of LH-RH as single stimulation and as long-term application for 7 days. Plasma levels of LH, FSH and testosterone were measured by specific radioimmunoassay. Th single LH-RG application stimulated both LH and FST secretion, while testosterone level remained unchanged in patients with Klinefelter syndrome. Long-term stimulation decreased basal LH and FSH levels and pituitary response to LH-RH . became close to normal. The testosterone level increased significantly in most patients with Klinefelter syndrome. This suggests that the Leydig cells in Klinefelter syndrome improved their activity, showing some functional reserve.

Adolescent↗
PubMed1977

[Secretory levels of plasma cortisol and aldosterone in normal pregnancy].

Fifty six females, aged 19-24 were examined ad pregnancy weeks. The plasma concentrations of aldosterone, cortisol, estradiol, estriol and progesteron were determined by radioimmunological methods. The results obtained reveal that the female sex hormones, during normal pregnancy, progressively grow, as well as those of cortisol and aldosteron. Those interrelations are of interest in the treatment of pregnant women with disturbances in the function of the endocrine glands and especially of suprarenal-cortex secretion.

Adult↗
PubMed1976

[Integrated stimulation test with releasing hormones on healthy men and on patients with various forms of male hypogonadism].

Ninety subjects were examined; 20 healthy males, 20 patients with primary hypogonadism, 30 patients with Klinefelter's syndrome and 20 patients with secondary hypogonadism. The stimulating test with 200 mug LH-RH and 200 mug TTH was carried out tp all subjects examined, applied in two successive o.v. injections. The plasma as regards the levels of TTH, prolactin, FSH, LH, ACTH and STH is investigated every 0,20, 30, 60 and 90 minutes. The levels of tbe mentioned hormones were determined as well as the normal respond reaction. The basic LH and FSH levels are considerabty elevated in patients with primary hypogonadism and Klinefelter's syndrome and the respond reaction to stimulation is normal or diminished. A strict correlation between the number of X chromosomes and the level of FSH and LH was established in the patients with Klinefelter's syndrome. With respect to TTH, the basic, level in patients with primary hypogonadism in normal in 13 patients and pathological deviations were found in 7 patients. A strict correlation between TTH level and the number of X-chromosomes exists, Prolactin level in both groups is decreased. In patients with secondary hypogonadism the basic level of LH and ESH is decreased or at the lower limits of the norm. The respond reaction is absent. Both TTH and prolactin levels are pathologically changed as well as the respond reactions to stimulation depending on the etiology of the primary endocrine distrubance that had led to hypoginadism development.

Adult↗
PubMedDate not supplied

[Onset of puberty in boys: comparison between clinical indicators and the changes in the plasma levels of gonadotropic hormones and testosterone].

The blood plasma LH, FSH and testosterone concentrations were determined in 155 boys aged, 10 to 17 years, by radioimmunoassay. The growth, body weight and puberty degree were detected according to Tanner and the testicular volume by Prader's orchidometer. It was found that hormonal changes in the hypothalamic-hypophyseal-testicular system proceed not parallelly to physical transformations, characteristic of puberty, i.e. hormone concentration rise is seen before the first phenotypical alterations and becomes maximum prior to puberty completion. FSH concentration is 1.67 times as high, reaching the maximum values by the pilar period of the 4th stage and the testicular volume of 8 to 12 ml. LH level is 1.47 times as high, reaching the maximum by the pilar period of the 3d stage and the testicular volume of 8 to 12 ml. Testosterone concentration is 10.47 times as high, reaching the maximum values by the pilar period of the 3d to 6th stage and the testicular volume of 12 to 16 ml. A decrease in the hypothalamic sensitivity to the blood circulating steroids plays a leading role in the puberty pathogenesis.

Adolescent↗