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Biomedical subjects

A Luger

Publications and source records attributed to A Luger.

At least 127 records · Page 7Linked to original sources
PubMed1982

[Exogenous zinc deficiency syndrome].

Two cases of acquired zinc deficiency after excessive bowel resection and total pancreatectomy and after total parenteral nutrition are reported. Skin lesions include diffuse hair loss and a psoriasis like dermatitis localized mainly at acral areas and around body orifices, which disappeared rapidly after oral supplementation of zinc sulfate. Clinical symptoms, etiological factors, differential diagnosis and therapy are discussed.

Adult↗
PubMed1982

Laboratory evidence for impaired cellular immunity in different stages of syphilis.

Abundant evidence suggests that Treponema pallidum (T.p.) escapes humoral immune defence despite the host produces antibodies early in the infection. Since the serologic responses in syphilis have been studied in detail this paper focuses on the cellular immune mechanisms. For this purpose the leukocyte migration inhibition was investigated in 17 patients in different stages of syphilis. Leukocyte migration inhibition assay was performed before, and 7 days, 3 weeks, 2 mo. and 1 yr after start of treatment. Ultrasonicated T.p. were used as antigen corresponding to 5 X 10(6) to 2 X 10(7) Treponema pallida per ml. Controls without antigen, with addition of Concanavalin. A instead of T.p. and using cells of normal volunteers were run. There was no leukocyte migration inhibition before treatment, suggesting nonexistent or depressed cellular immunity in the untreated syphilitic patient. Significant leukocyte migration inhibition, however, was observed as early as 2 days after start of treatment, being most pronounced after 1 week. Hypothetical circulating blocking factors for cellular immune reactions might be present in the untreated syphilitic patient, which become abolished after therapy. Since stimulation with Con A of syphilitic leukocytes gave normal results even before treatment in the syphilitic patient, there might be a specific block of leukocyte migration inhibition against T.p.

Cell Migration Inhibition↗
PubMed1981

[Condylomata acuminata].

Condylomata acuminata are benign epitheliomas which are caused by the human papilloma virus. 8 subgroups (variants) of the virus are known up to now. Condylomata acuminata are infectious, the virus being transferred by direct contact with a lesion. Condylomata acuminata are found more often in males than in females and never occur in children prior to the age of two years. The peak incidence is between 19 and 22 years of age. Greatly proliferating condylomata acuminata (type Buschke-Löwenstein) may lead to malignant degeneration. There exists a broad spectrum of topical therapeutic modalities: cytotoxic substances such as podophyllin (10 to 25%), colchicine (8%), 5-fluorouracil (1 to 5%), cryotherapy (solid carbon dioxyde or liquid nitrogen), surgical treatment (excochleation, electrocautery or laser beam. Vaccination therapy may prove successful in certain cases in the future.

Adult↗
PubMed1981

[Serological diagnosis of syphilis by the SPHA test (author's transl)].

Despite the availability of a broad spectrum of specific and non-specific tests for the serodiagnosis of syphilis, the interpretation of the results may be difficult and may frequently not provide sufficient information for a precise decision on the needs for antisyphilitic treatment. The present paper reports on the serological IgM tests (IgM-FTA-ABS; 19S-IgM-FTA-ABS) and, in particular, on the newly-developed SPHA test (solid phase hemadsorption). Present experience indicates that for the first time in syphilis serology this test unifies the advantages of high specificity, high sensitivity, low costs and extraordinary clinical value for the decision whether or not the patient needs antisyphilitic treatment.

Diagnosis, Differential↗
PubMed1981

Modification of cation permeability of rabbit descending colon by sulphydryl reagents.

1. Addition of the organic mercurials mersalyl, p-chloromercuribenzoate, and p-chloromercuribenzene sulphonate to the Ringer solution (140 mM-Na) bathing the luminal side of isolated epithelia of rabbit descending colon increases short-circuit current (Isc) and tissue conductance (Gt) when the spontaneous Isc is below 2-3 muequiv/cm2 hr. 2. The stimulation of Isc by mersalyl is due to an increase in Na absorption, simultaneously K secretion is induced, whereas Cl absorption is not affected. 3. Mersalyl inhibits Isc at Na concentrations below 50 mM. The Na concentration at which Isc is half-maximal (KNa) is shifted by mersalyl from 25 to 133 mM. The overshoot in Isc to a peak volume of 5 muequiv/cm2 hr observed when Na-depleted tissues are suddenly exposed to Na is markedly depressed by mersalyl. 4. Mersalyl inhibits non-competitively the blocking effect of amiloride on Isc. Both the stimulation of Isc and the inhibition of the amiloride effect by mersalyl have the same time course (half-time of the effects 30-40 min) and similar concentration-response curve (half-maximal effects with 2.0-2.6 x 10(-4) M), indicating a common mechanism. 5. The mersalyl effects on Isc and on the amiloride action are only partially reversed by dimercaptopropanol. p-Chloromercuribenzoate conjugated with dextran (mol. wt. 10,000) elicited the same effects as mersalyl. 6. The stoichiometry of the mersalyl-amiloride interaction, estimated by use of the Hill plot, is 1:1; a Hill coefficient of 1 was also obtained for the stimulating effect of mersalyl on Isc. 7. It is concluded that one sulphydryl group per luminal Na entry site controls both its Na conductance and cation selectivity. Titration of these sulphydryl groups by organic mercurials appear to fix the conductance of the luminal Na entry mechanism in a submaximal position and prevent its modulation by amiloride or variations in intra- and/or extracellular Na concentrations.

Amiloride↗
PubMed1981

Specificity of the Treponema pallidum haemagglutination test. Analysis of results.

The automated haemagglutination assay using Treponema pallidum antigen (AMHA-TP) and the Venereal Disease Research Laboratory (VDRL) test were used to examine 330 163 sera. Reactive results were checked by the fluorescent treponemal antibody-absorption (FTA-ABS) test. When isolated reactivity or non-reactivity in the AMHA-TP test was investigated an estimated margin of error of 0.7% probably wrongly non-reactive and 0.008% presumably false non-reactive results were found. These figures were confirmed by randomised FTA-ABS tests on 504 sera with repeat AMHA-TP tests. The latter is therefore still the most reliable and practicable method for mass screening for syphilis.

Antibodies, Bacterial↗
PubMed1981

Diagnosis of neurosyphilis by examination of the cerebrospinal fluid.

Thirty-six patients with reactive results in the cerebrospinal fluid to the Treponema pallidum haemagglutination assay (CSF-TPHA) were investigated by further serological tests for confirmation of active neurosyphilis. The results of the TPHA and fluorescent treponemal antibody tests were reactive in all CSF samples from patients with acute untreated neurosyphilis and from most patients with late latent syphilis but no signs of involvement of the central nervous system. The demonstration of 19S-IgM antibodies against Treponema pallidum in the CSF was a better indication of activity of the disease than the Venereal Disease Research Laboratory test. Ten of 11 patients with untreated acute neurosyphilis had reactive results in the solid-phase haemadsorption test for CSF-IgM (CSF-IgM-SPHA test). The TPHA index, which relates the CSF-TPHA titre to the albumin quotient and thus excludes errors from disturbed function of the blood-brain barrier, was above 100 in all but one of the patients with acute neurosyphilis but below 100 after treatment. Patients with late latent syphilis and without CNS signs had TPHA indices below 5. Thus a nonreactive CSF-TPHA test result excludes neurosyphilis but reactive CSF-IgM-SPHA results and TPHA indices above 100 strongly indicative active disease.

Adult↗
PubMed1981

Cerebrospinal fluid immunoglobulins in neurosyphilis.

Using the fluorescent treponemal antibody-absorption (FTA-ABS) test and the solid phase haemadsorption assay (SPHA) Treponema pallidum-specific IgA was found in the cerebrospinal fluid (CSF) of patients with neurosyphilis but not in those with late latent syphilis. The presence of T pallidum-specific IgA in the CSF may inhibit the antitreponemal activity of IgG and thus play some part in the pathogenesis of neurosyphilis.

Aged↗
PubMed1981

Diagnosis of syphilis.

The demonstration of Treponema pallidum in early specimens is still the most important procedure for definite diagnosis of the disease. Nonspecific lipoidal antigen tests, as well as assays using T. pallidum antigen, are used for the detection of antibodies in sera. The techniques, the interpretation of the results, the onset and limits of reactivity, as well as the sources of error of the VDRL (RPR), FTA-ABS, TPHA (MHA-TP, AMHA-TP), IgM FTA-ABS, I9S IgM-FTA-ABS, and IgM-SPHA tests are described. The presence of 19S IgM antibodies against T. pallidum indicates activity of the disease and their disappearance is evidence of cure. Positive results in the VDRL test are also strongly suggestive of active disease but are less precise. A TPHA index for CSF of more than 100 and a positive result in the IgM-SPHA test on CSF are indicative for neurosyphilis.A haemagglutination assay is suggested for screening, if possible combined with the VDRL test. The FTA-ABS test is recommended for confirmation of the diagnosis and the response to treatment can be assessed by the IgM-SPHA test or by changes in the VDRL titre.

Hemagglutination Tests↗
PubMed1981

[Skin necroses in cryoglobulinemia].

The dermatological symptoms of cryoglobulinemia and the simple demonstration of cryoproteins by cooling of serum and plasma respectively is described in a patient.

Aged↗
PubMed1980

[Therapy of sexually transmissible diseases].

Penicillin is still the drug of first choice for the treatment of Syphilis and Gonorrhoea. The therapy of infections with Treponema pallidum requires long lasting stabile blood and tissue levels, Neisseria gonorrhoeae can be eradicated by high serum concentrations of short duration. Chancroid and Donovanosis respond well to tetracylines, macrolide antibiotics and aminoglycosides while the application of sulfonamides or tetracyclines is suitable for the control of Lymphogranuloma venereum. Metronidazole or nimorazole derivatives may cure Trichomoniasis. Infections with Mycoplasmas (Urea-plasma) or Chlamydiae can be treated by tetracyclines only. Genital candidosis usually disappears after topical use of miconazole- or econazole- or clotrimazole-ointments. Herpes genitalis cannot be influenced by pharmacotherapeutical means, relapsing forms may be suppressed by vaccination. Mollusca contagiosa should be removed by the surgical spoon and genital warts can be destroyed by electrocautherization or by topical application of podophyllin solution.

Anti-Bacterial Agents↗