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Biomedical subjects

A Luger

Publications and source records attributed to A Luger.

At least 145 records · Page 8Linked to original sources
PubMed1980

Recent observations on the serology of syphilis.

Routine screening of 404 742 sera by the automated micro-haemagglutination assay (AMHA-TP) and the Venereal Disease Research Laboratory (VDRL) test showed that 9848 specimens gave a reactive result to one of the three assays. Reactive results were confirmed by the fluorescent treponemal antibody absorption (FTA-ABS) test. The possibility of false-positive results varied from 0.04-0.38% of all specimens or from 1.7-15.7% of reactive sera. The VDRL test failed to detect reactivity in 56.54% of sera from patients who had previously been infected with Treponema pallidum. The importance of routine testing by the AMHA-TP is illustrated by the detection of four patients with mesaortitis and two with active neurosyphilis among a selected group of 54 patients who had non-reactive results to the VDRL test. Testing of cerebrospinal fluid specimens by the AMHA-TP test produced more specific results than by the other two tests.

Antibodies, Bacterial↗
PubMed1980

Comparative effect of x-ray and ultrasound (inducing hyperthermia) on the testes of rats--a rationale for male castration by ultrasound.

The testes of rats were treated by x rays, or ultrasound. 2000 rads single dose of x ray led to tubular atrophy, which was defined as destruction of all spermatogenic cells but Sertoli cells. Ultrasound of 1 W/cm2 for 15 min led to tubular necrosis, which was designated as complete disorganization of the seminiferous tubules with disappearance of spermatogenic as well as sertoli cells. The possibility of male castration by ultrasound is raised.

Animals↗
PubMed1980

[Recent developments in the field of syphilis serology (author's transl)].

All lipoid antigen tests are outdated except for the VDRL and RPR or RPRC and even these methods will be superseded in the near future. The TPI (Nelson-Mayer) test has been replaced by more reliable assays. The micro-haemagglutination assay with Tr. pallidum antigen (MHA-TP) or its automated version (AMPHA-TP) serve for screening. Reactive results in the AMPHA-TP have to be checked by the FTA-ABS. Reactivity to both tests indicates an infection with Tr. pallidum. The margin of error of this method is as low as 0.04 to 0.45%. The VDRL titre indicates, as yet, the activity of a syphilitic infection and the limit appears to be around 1 : 8. A decrease in the VDRL titre after adequate treatment suggests a successful therapeutic outcome. More reliable methods for assessing the necessity of treatment, as well as the results of therapy and the distinction between relapse and reinfection are provided by the identification of 19S-IgM-antibodies to Tr. pallidum by means of the 19S-IgM-FTA-ABS or the SPHA (SPIT) test. These assays will soon be available as routine procedures and their application will terminate the traditional era of lipoid antigen serology which has lasted for more than 70 years.

Antigens↗
PubMed1980

[Recent findings in the field of humoral immunology in syphilis].

Investigations on 404742 sera by the Automated Micro-Haemagglutination Assay with Treponema pallidum Antigen (AMHA-TP) and the VDRL-test for screening revealed 9848 (2,43%) reactive results in one of the two or in both methods. All reactive samples were checked by the FTA-ABS-test. A reactivity in both, the AMHA-TP and the FTA-ABS indicates a former infection with Treponema pallidum. The VDRL failed to point out reactivity in 4226 of 7474 sera (56,5%) deriving from syphilitic donors. The agglutination in the AMHA-TP can be inhibited by a protein of low molecular weight which occurs appearently in extraordinarily rare cases and was found in one sample only until now. The margin of error of the screening procedure by using the AMHA-TP and the VDRL amounts to 0,04%-0,38% of all samples examined.

Agglutination Tests↗
PubMed1980

[Inhibition of sodium transport in the colon by the diuretic amiloride (author's transl)].

In isolated epithelia of rabbit descending colon the short-circuit current (Isc) is solely attributable to net transepithelial Na-transport, which in turn is identical with the unidirectional Na-influx across the luminal cell membranes. Amiloride blocks Isc by inhibiting luminal Na-influx into the cells. The type of inhibition exerted by amiloride in this tissue has to be termed mixed-type, since both the affinity of Na to its transport system and the maximal transport capacity are reduced. Na, on the other hand, is a competitive antagonist of the amiloride effect with a Ki of 136 mM; therefore KA, the amiloride-concentration at which the amiloride-effect is half-maximal, is increased from 0.14 microM at 5 mM Na in the incubation medium to 0.29 microM at 140 mM Na. It is conceivable that an "amiloride-like" action of Na may be responsible for the saturability of luminal Na-influx with increasing Na-concentrations.

Amiloride↗
PubMed1979

[The purine salvage pathway in erythrocytes of psoriatic patients].

Investigations on the purine-salvage-pathway in erythrocytes of 3 patients with psoriasis and of 3 healthy control persons revealed equivocal differences. The transfer of 14C-adenine to adenosine-monophosphat as well as the uptake of 14C-guanine is markedly increased and the incorporation of 14C-hypoxanthine deviates in psoriatics from the controls. A correlation between these findings and the clinical course could not be observed. The paper presents first results of a study concerning the synthesis of nucleotides in the course of the reutilisation of purines within erythrocytes of psoriatic patients.

Erythrocytes↗
PubMed1979

[Serological demonstration of a Treponema pallidum reinfection].

An improved method for precise separation of 19-S-IgM from other immunoglobulines reveals the reappearance of antitreponemal 19-S-IgM-antibodies after reinfection in five patients. The IgM-FTA-ABS-test with non-separated full-serum was non-reactive in all cases due to competitive inhibition. The new assay apparently permits a clear differentiation between reinfection and non-specific increase of titers in lipoidal antigen tests. Treatment failures can be distinguished from reinfections in cases where this method can continuously be applied.

Adult↗
PubMed1979

[A new method for serologic detection of Treponema pallidum reinfection].

Sources of error in the detection of specific IgM-antibodies against Treponema pallidum could be overcome by the introduction of a new method for precise separation of immunoglobulins. The 19-S-IgM-FTA-ABS-test apparently permits a correct diagnosis of syphilitic reinfection. This method is not only specific but also earlier reactive than the VDRL-test. The short-time persistence of 19 S-IgM production after treatment and its renewed appearance enables for the first time a differentiation between treatment failure and reinfection.

Adolescent↗