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Biomedical subjects

A Jankowski

Publications and source records attributed to A Jankowski.

At least 73 records · Page 4Linked to original sources
PubMed1987

The concentration of IgD in blood sera of children suffering from dys- or hypogammaglobulinaemia of class A.

6580 children inhabitans of selected region of Lower Silesia and 475 children with recurrent respiratory tract infections as well as 65 children with chronic active hepatitis were tested. IgA level was determined in each case. In the cases where IgA was absent or a low level of this immunoglobulin was found (0.2 g/l) IgD concentration was determined. It was established that the frequency of dysgammaglobulinaemia of class A was 1/731 tested cases in the tested population and 1/119 cases in children with respiratory tract infections and 1/65 tested children with chronic active hepatitis. Hypogammaglobulinaemia of class A was found in 1/365 cases in the tested population and 1/20 cases in children with respiratory tract infections and 2/65 children with chronic aggressive hepatitis. In children with dysgammaglobulinaemia of class A lack of IgD in serum was found in 44% of the cases--however, in hypogammaglobulinaemia IgA lack of IgD in serum was found in 38% of the cases.

Adolescent↗
PubMed1987

Immunostimulation in recurrent respiratory tract infections therapy in children.

Selected immunologic parameters and effectivity of immunotherapy was evaluated in 117 children (12-month-10-year-1-old) suffering from recurrent respiratory tract infections. All the children displayed a profound depression of T lymphocytes number, which resemble the situation seen in AIDS patients. An increase of serum IgM concentration was also noted. Immunotherapy included treatment with the following preparations: TFX and Levamisol which stimulate T cell functions, Broncho-Vaxom which stimulates specific antibody production and a complex herb preparation PADMA showing undefined general stimulatory activity. Separate group of children was subjected to climatotherapy in Czerniawa Sanatorium and received no immunostimulants. All methods of treatment employed had beneficial effect. The highest percentage of positive results was obtained in children receiving TFX and Levamisol. In all groups under study, an elevation of T cells percentage was observed. This was especially evident in Levamisol treated patients. There was no correlation, however, between T cells number and clinical improvement.

Adjuvants, Immunologic↗
PubMed1987

The labelling of peptides and proteins with a new fluorophore: N-acetyl-DL-(p-N',N'-dimethylamino)phenylalanine.

It was found that N-acetyl-DL-(p-N',N'-dimethylamino)phenylalanine, in the form of azlactone, can be introduced into a peptide or protein molecule as a new convenient fluorescent marker. A fluorophore of similar properties: N-acetyl-(p-amino)phenylalanine can be introduced into a peptide chain by the reaction with the azlactone of N-acetyl-(p-nitro)phenylalanine followed by reduction of nitro group to amino group. This method, however, cannot be applied to proteins.

Fluorescent Dyes↗
PubMed1985

Clinical-pharmacokinetic investigations of acetylsalicylic acid in cases of imminent premature delivery.

The pharmacokinetics of acetylsalicylic acid have been examined in a dose of 3.6 g per day (0.9 g every 6 h) for 4 days, and the effect of the drug in 25 gravidae, threatened by premature delivery, has also been studied. Salicylate in maternal blood was higher than in amniotic fluid, umbilical cord and foetus at birth. It is concluded that 9 h after a dose of 3.6 g acetylsalicylic acid, the salicylate level in maternal blood was sufficient to reduce the number of uterine spasms in most patients. No effect of the drug on blood coagulation in mother or child was observed.

Amniotic Fluid↗